Association between Cell Membrane Potential and Breast Cancer
Abstract
Cell membrane potentials were measured in breast tissue and in breast epithelial cells to explore the relation between cell membrane potentials, oncogenesis and electrical potentials previously measured on the surface of the breast. The mean membrane potential in breast biopsy tissue from 9 women with infiltrating ductal carcinoma was significantly depolarized, compared with values measured in tissue from 8 women with benign breast disease. Depolarization was also observed in transformed breast epithelial cells, compared with normal breast cells; the transformed cells were particularly sensitive to the action of K+ channel blockers. The results were consistent with previous observations of electropositivity of skin sites over malignant tumors of the breast.
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Cancer cells possess a relatively more depolarized resting membrane potential compared to non-cancer cells.
“Indeed, cancer cells are known to possess a relatively more depolarized resting membrane potential compared to non-cancer cells [28,29,30,31].”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [29]
Cancer cells have a relatively depolarized resting Vm compared to non-cancer cells, observed in various cellular types of the brain.
“Further evidence of the relatively depolarized resting Vm of cancer cells in comparison to that of non-cancer cells has been observed in various cellular types of the brain (summarized in Table S4) [81,82,83].”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [29]
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The Universal Role of Adaptive Transcription in Health and DiseasePreprint
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A non-equilibrium thermodynamic approach to symmetry breaking in cancer
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“Indeed, depolarization has been noted in transformed breast epithelial cells, which were particularly sensitive to the action of K+ channel blockers (Marino et al. 1994).”
BackgroundQi and Bioelectromagnetic Energy
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“Higher levels of Na+ and lower levels of K+ have been reported in cancer cells compared to those in normal cells [48,49].”
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Study on the Effects of Magnetic Stimulation on K-Ras-Driven Lung Cancer in Mice
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- Authors
- Marino, A. A., Iliev, I. G., Schwalke, M. A., Gonzalez, E., Marler, K. C., & Flanagan, C. A.
- Affiliations
- Louisiana State University (US)
- ORCID
- Marino, Andrew A.
- Venue
- Tumor Biology
- Published
- 1994
- Volume
- 15
- Issue
- 2
- Pages
- 82-89
- ISSN
- 1010-4283 (ISSN-L)
- 1423-0380
- OpenAlex
- W2052787194
- Cited by
- 116
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 1 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tumor Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant and Biological Electrophysiology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- membrane potential, breast cancer, invasive ductal carcinoma, breast epithelial cells, membrane depolarization, carcinogenesis, potassium channel blockers, benign breast disease
- MeSH terms
- Adult, Aged, Breast, Breast Neoplasms, Cell Membrane, Female, Humans, Membrane Potentials, Middle Aged, Potassium Channels, Carcinoma, Ductal, Breast
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