Ion channels and the hallmarks of cancer
Abstract
Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion channels in cancer in the context of their involvement in the defined hallmarks of cancer: 1) self-sufficiency in growth signals, 2) insensitivity to antigrowth signals, 3) evasion of programmed cell death (apoptosis), 4) limitless replicative potential, 5) sustained angiogenesis and 6) tissue invasion and metastasis. Recent studies have indicated that the contribution of specific ion channels to these hallmarks varies for different types of cancer. Therefore, to determine the importance of ion channels as targets for cancer diagnosis and treatment their expression, function and regulation must be assessed for each cancer.
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Vm is regarded as an indirect factor that can affect cell migration, whose main regulatory role might be setting up the electrical driving force for Ca2+.
“Vm is regarded as an indirect factor that can affect cell migration, whose main regulatory role might be setting up the electrical driving force for Ca2+ (Prevarskaya et al., 2010; Schwab et al., 2012).”
From Membrane potential and cancer progression (2013) · cites this paper as Prevarskaya et al., 2010
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Membrane potential and cancer progression
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- Authors
- Prevarskaya, N., Skryma, R., & Shuba, Y.
- Affiliations
- Inserm (FR)
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 16
- Issue
- 3
- Pages
- 107-121
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2015021076
- Cited by
- 448
- References
- 3
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 29 · 2023: 34 · 2022: 45 · 2021: 24 · 2020: 44 · 2019: 43 · 2018: 28 · 2017: 20 · 2016: 17 · 2015: 32 · 2014: 36 · 2013: 19 · 2012: 21
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- ion channels, cancer hallmarks, plasma membrane ion channels, apoptosis evasion, angiogenesis, metastasis, tissue invasion, cancer diagnosis, cancer therapy targets
- MeSH terms
- Animals, Humans, Ion Channels, Models, Biological, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Apoptosis, Cell Proliferation
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