The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Diagnosis and management of non-erosive reflux disease–the Vevey NERD Consensus Group
Open accessAbstract
BACKGROUND/AIMS: Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS: An expert international group using the modified Delphi technique examined the quality of evidence and established levels of agreement relating to different aspects of NERD. Discussion focused on clinical presentation, assessment of clinical outcome, pathobiological mechanisms, and clinical strategies for diagnosis and management. RESULTS: Consensus was reached on 85 specific statements. NERD was defined as a condition with reflux symptoms in the absence of mucosal lesions or breaks detected by conventional endoscopy, and without prior effective acid-suppressive therapy. Evidence supporting this diagnosis included: responsiveness to acid suppression therapy, abnormal reflux monitoring or the identification of specific novel endoscopic and histological findings. Functional heartburn was considered a separate entity not related to acid reflux. Proton pump inhibitors are the definitive therapy for NERD, with efficacy best evaluated by validated quality-of-life instruments. Adjunctive antacids or H(2) receptor antagonists are ineffective, surgery seldom indicated. CONCLUSIONS: Little is known of the pathobiology of NERD. Further elucidation of the mechanisms of mucosal and visceral hypersensitivity is required to improve NERD management.
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“These findings are similar to what is observed in human microscopic reflux esophagitis, and would be assigned a Grade M in accordance with the updated Los Angeles classification [2].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [2]
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“Postprandial hyperglycemia is a risk factor for acid reflux and the development of non-erosive esophagitis.”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [2]
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Citations
Cites
4 retracted
Medical treatments in the short term management of reflux oesophagitis
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Metadata
- Authors
- Modlin, I. M., Hunt, R. H., Malfertheiner, P., Moayyedi, P., Quigley, E. M., Tytgat, G. N. J., Tack, J., Heading, R. C., Holtman, G., & Moss, S. F.
- Affiliations
- Yale University (US)
- McMaster University Medical Centre (CA)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University College Cork (IE)
- University of Amsterdam (NL)
- KU Leuven (BE)
- Glasgow Royal Infirmary (GB)
- Brown University (US)
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 80
- Issue
- 2
- Pages
- 74-88
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- PMC
- PMC2790735
- OpenAlex
- W1990566132
- Cited by
- 154
- References
- 96
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 12 · 2013: 9 · 2012: 11
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Digestion (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Durham Research Online (Durham University) (acceptedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Keywords
- non-erosive reflux disease, gastroesophageal reflux disease, proton pump inhibitors, acid suppression, functional heartburn, visceral hypersensitivity, reflux monitoring, antacids, H2 receptor antagonists, antireflux surgery, quality of life, pathobiology
- MeSH terms
- Gastroesophageal Reflux, Humans, Quality of Life, Severity of Illness Index, Practice Guidelines as Topic
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