Cited by 154Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studies

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Diagnosis and management of non-erosive reflux disease–the Vevey NERD Consensus Group

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Modlin, I.M., Hunt, R.H., Malfertheiner, P., Moayyedi, P., Quigley, E.M., Tytgat, G.N.J., Tack, J., Heading, R.C., Holtman, G., Moss, S.F.·2009·Digestion

DOI 10.1159/000219365PMC PMC2790735

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Abstract

BACKGROUND/AIMS: Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS: An expert international group using the modified Delphi technique examined the quality of evidence and established levels of agreement relating to different aspects of NERD. Discussion focused on clinical presentation, assessment of clinical outcome, pathobiological mechanisms, and clinical strategies for diagnosis and management. RESULTS: Consensus was reached on 85 specific statements. NERD was defined as a condition with reflux symptoms in the absence of mucosal lesions or breaks detected by conventional endoscopy, and without prior effective acid-suppressive therapy. Evidence supporting this diagnosis included: responsiveness to acid suppression therapy, abnormal reflux monitoring or the identification of specific novel endoscopic and histological findings. Functional heartburn was considered a separate entity not related to acid reflux. Proton pump inhibitors are the definitive therapy for NERD, with efficacy best evaluated by validated quality-of-life instruments. Adjunctive antacids or H(2) receptor antagonists are ineffective, surgery seldom indicated. CONCLUSIONS: Little is known of the pathobiology of NERD. Further elucidation of the mechanisms of mucosal and visceral hypersensitivity is required to improve NERD management.

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[Pathophysiology of gastroesophageal reflux disease: motility factors].
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Research works printed but not linked: 4

10.1007%2Fs12171-007-0027-8 · DOI
10.1007%2Fs12171-007-0026-9 · DOI
10.1111%2Fj.1365-2036.2007.03520.x · DOI
10.1016%2Fj.gie.2006.03.635 · DOI

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See all 154

Authors: Modlin, I. M., Hunt, R. H., Malfertheiner, P., Moayyedi, P., Quigley, E. M., Tytgat, G. N. J., Tack, J., Heading, R. C., Holtman, G., & Moss, S. F.
Affiliations: Yale University (US)
McMaster University Medical Centre (CA)
Otto-von-Guericke-Universität Magdeburg (DE)
University College Cork (IE)
University of Amsterdam (NL)
KU Leuven (BE)
Glasgow Royal Infirmary (GB)
Brown University (US)
ORCID: Hunt, R.H.
Malfertheiner, P.
Moayyedi, P.
Quigley, E.M.
Tack, J.
Heading, R.C.
Moss, S.F.
Venue: Digestion
Publisher: S. Karger AG
Published: 2009
Volume: 80
Issue: 2
Pages: 74-88
ISSN: 0012-2823 (ISSN-L)
1421-9867
DOI: 10.1159/000219365
PMC: PMC2790735
OpenAlex: W1990566132
Cited by: 154
References: 96
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 12 · 2013: 9 · 2012: 11
FWCI: 12.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Digestion (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Durham Research Online (Durham University) (acceptedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Durham Research Online (Durham University) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Keywords: non-erosive reflux disease, gastroesophageal reflux disease, proton pump inhibitors, acid suppression, functional heartburn, visceral hypersensitivity, reflux monitoring, antacids, H2 receptor antagonists, antireflux surgery, quality of life, pathobiology
MeSH terms: Gastroesophageal Reflux, Humans, Quality of Life, Severity of Illness Index, Practice Guidelines as Topic

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Diagnosis and management of non-erosive reflux disease–the Vevey NERD Consensus Group

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