Cited by 309Skin and Cellular Biology ResearchNeonatal skin health careDermatology and Skin Diseases

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Development of the Epidermis in the Newborn

Evans, N.J., Rutter, N.·2009·Biology of the Neonate

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Abstract

Histological development of the epidermis was studied on skin samples from 169 infants (gestation 24–40 weeks, age up to 1 year). Gestation markedly influenced epidermal development. Before 30 weeks, the epidermis is thin, has few cell layers and a poorly formed stratum corneum, but by 34 weeks it has largely matured. Postnatal influence on epidermal development is marked in the preterm infant, so that histologically the epidermis of the most immature infant resembles that of a term infant by 2 weeks of age. These changes in histology exactly parallel the development of the barrier properties of newborn skin.

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Authors: Evans, N. J., & Rutter, N.
Affiliations: Nottingham City Hospital (GB)
Corresponding author: Evans, N.J.
Rutter, N.
ORCID: Rutter, N.
Venue: Biology of the Neonate
Publisher: S. Karger AG
Published: 2009-09-24
Volume: 49
Issue: 2
Pages: 74-80
ISSN: 0006-3126 (ISSN-L)
1421-9727
DOI: 10.1159/000242513
OpenAlex: W2032893178
Cited by: 305
References: 0
Citations by year: 2026: 1 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 19 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 10
FWCI: 5.91
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Biology of the Neonate (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal skin health care
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: epidermal development, neonatal skin, skin histology, stratum corneum, gestational age, preterm infants, postnatal maturation, skin barrier function, epidermal cell layers
MeSH terms: Epidermis, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Skin

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Development of the Epidermis in the Newborn

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