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Development of the Epidermis in the Newborn
Abstract
Histological development of the epidermis was studied on skin samples from 169 infants (gestation 24–40 weeks, age up to 1 year). Gestation markedly influenced epidermal development. Before 30 weeks, the epidermis is thin, has few cell layers and a poorly formed stratum corneum, but by 34 weeks it has largely matured. Postnatal influence on epidermal development is marked in the preterm infant, so that histologically the epidermis of the most immature infant resembles that of a term infant by 2 weeks of age. These changes in histology exactly parallel the development of the barrier properties of newborn skin.
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“At 24 to 30 weeks gestation, the epidermis is 60% as thick as it is at 36 to 40 weeks (20), and it is considerably more fragile.”
From Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care (2019) · cites this paper as [20]
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Basic anatomical and physiological data for use in radiological protection: reference values
Valentin, J. (2002) · Annals of the ICRP · doi:10.1016/s0146-6453(03)00002-2 · Cited by 2,024
“(504) The postnatal influence on cellular development of the epidermis is marked in preterm infants so that the epidermis of even the most immature infant (24–28 weeks of gestation) resembles that of the term infant (36–40 weeks of gestation) after about 2 weeks (Evans and Rutter, 1986).”
BackgroundBinodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
Chung, H. U., Kim, B. H., Lee, J. Y., Lee, J., Xie, Z., Ibler, E. M., Lee, K., Banks, A., Jeong, J. Y., Kim, J., et al. (2019) · Science · doi:10.1126/science.aau0780 · Cited by 807
Basic anatomical and physiological data for use in radiological protection : reference values
Valentin, J. (2002) · Medical Entomology and Zoology · Cited by 680
Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants
Kaufman, D. A., & Fairchild, K. D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.638-680.2004 · Cited by 437
“Placement of peripheral and central vascular catheters, use of chest tubes, and frequent blood drawing further compromise the skin (37, 76, 130), exposing the deeper layers of the epidermis, to which organisms may adhere and then may proliferate and disseminate (425).”
BackgroundPatterned acquisition of skin barrier function during development
Hardman, M. J., Sisi, P., Banbury, D. N., & Byrne, C. (1998) · Development · doi:10.1242/dev.125.8.1541 · Cited by 385
Metadata
- Authors
- Evans, N. J., & Rutter, N.
- Affiliations
- Nottingham City Hospital (GB)
- Corresponding author
- Evans, N.J.
- Rutter, N.
- ORCID
- Rutter, N.
- Venue
- Biology of the Neonate
- Publisher
- S. Karger AG
- Published
- 2009-09-24
- Volume
- 49
- Issue
- 2
- Pages
- 74-80
- ISSN
- 0006-3126 (ISSN-L)
- 1421-9727
- OpenAlex
- W2032893178
- Cited by
- 305
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 19 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 10
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of the Neonate (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal skin health care
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- epidermal development, neonatal skin, skin histology, stratum corneum, gestational age, preterm infants, postnatal maturation, skin barrier function, epidermal cell layers
- MeSH terms
- Epidermis, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Skin
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