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Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis
Open accessAbstract
Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.
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Citations
Cited by
Cellular and molecular mechanisms of renal fibrosis
Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,446
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
Jun, J.-I., & Lau, L. F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3599 · Cited by 568
Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424
NOGUEIRA, A., PIRES, M. J., & OLIVEIRA, P. A. (2017) · In Vivo · doi:10.21873/invivo.11019 · Cited by 382
The CCN family: A new class of inflammation modulators?
Kular, L., Pakradouni, J., Kitabgi, P., Laurent, M., & Martinerie, C. (2011) · Biochimie · doi:10.1016/j.biochi.2010.11.010 · Cited by 183
Metadata
- Authors
- Phanish, M. K., Winn, S. K., & Dockrell, M. E. C.
- Venue
- Nephron Experimental Nephrology
- Publisher
- S. Karger AG
- Published
- 2009-12-02
- Volume
- 114
- Issue
- 3
- Pages
- e83-e92
- ISSN
- 1660-2129 (ISSN-L)
- OpenAlex
- W2169748382
- Cited by
- 179
- References
- 0
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis. https://app.cochat.ai/papers/10.1159/000262316
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- Phanish, M. K., Winn, S. K., & Dockrell, M. E. C. (2009). Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis. Nephron Experimental Nephrology. https://doi.org/10.1159/000262316
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
