The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Developmental Origins of Adult Disease
Open accessAbstract
Variation in the quality or quantity of nutrients consumed during pregnancy can exert permanent and powerful effects upon the developing fetus. This programming of fetal development is emerging as a new risk factor for non-communicable diseases of adulthood, including coronary heart disease and the metabolic syndrome. Epidemiological studies show that indicators of nutritional deficit in pregnancy are associated with greater risk of diabetes and cardiovascular mortality. The study of programming in relation to disease processes has been advanced by the development of animal models, which have utilized both under- and overfeeding of specific nutrients in pregnancy. Studies of this nature support the nutritional programming hypothesis and provide tools with which to examine the mechanisms through which programming may occur. Studies of animals subject to undernutrition in utero generally exhibit changes in the structure of key organs, such as the kidney and pancreas. These effects are consistent with the concept that programming influences remodel the development of organs. The causal pathways which extend from tissue remodelling to disease processes are relatively well characterised. In contrast, the processes which drive disordered organ development are poorly understood. It is noteworthy that minor perturbation of maternal nutritional status can programme fetal development. It is suggested therefore that programming is a product of altered expression of key genes. This drives the tissue remodelling response and future disease risk.
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Cites
Epigenetic differences arise during the lifetime of monozygotic twins
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Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Fetal and placental size and risk of hypertension in adult life.
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Obesity in Young Men after Famine Exposure in Utero and Early Infancy
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Cited by
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Childhood obesity and risk of the adult metabolic syndrome: a systematic review
Dunford, L. J., Langley-Evans, S. C., & McMullen, S. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.186 · Cited by 365
Self-citationThe Developmental Origins of Health and Disease (DOHAD)
Lacagnina, S. (2020) · American Journal of Lifestyle Medicine · doi:10.1177/1559827619879694 · Cited by 244
Varcoe, T. J., Wight, N., Voultsios, A., Salkeld, M. D., & Kennaway, D. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018504 · Cited by 147
Eckert, J. J., Porter, R., Watkins, A. J., Burt, E., Brooks, S., Leese, H. J., Humpherson, P. G., Cameron, I. T., & Fleming, T. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052791 · Cited by 119
Metadata
- Authors
- Langley-Evans, S. C., & McMullen, S.
- Venue
- Medical Principles and Practice
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 19
- Issue
- 2
- Pages
- 87-98
- ISSN
- 1011-7571 (ISSN-L)
- 1423-0151
- OpenAlex
- W2038170239
- Cited by
- 263
- References
- 14
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
