Determinants of Quality of Life in Nursing Home Residents with Dementia
Abstract
Aims: The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. Methods: This cross-sectional observational study included 288 individuals with dementia who reside in 14 special care units in 9 nursing homes. The following measures were used: the Qualidem scale to assess QoL, the Neuropsychiatric Inventory-Nursing Home version, the Global Deterioration Scale (GDS), the Severe Impairment Battery-short version, an Activities of Daily Living scale and PDU. Associations between QoL and NPS were examined using multivariate linear regression models with corrections for potential covariates. Results: The average age of the residents was 84 years (SD = ±7). Agitation, depression, psychosis, psychomotor agitation and psychotropic drugs were independently associated with poor QoL. In patients with mild to moderately severe dementia (GDS 4–6), NPS, PDU and cognitive impairment explained almost half of the variance in QoL scores. Agitation and depression were particularly strong predictors of poor QoL. In patients with severe dementia (GDS 7), agitation, depression, psychosis and cognitive impairment were associated with poor QoL. Conclusions: NPS, cognition and PDU independently impair QoL for patients in both the moderate and advanced stages of dementia. These results challenge existing pharmacological intervention strategies and highlight the need for psychosocial interventions in the treatment of NPS.
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The review included three RCTs of light therapy, all in care homes.
“We included three RCTs, all in care homes. 40-42”
From Non-pharmacological interventions for agitation in dementia: systematic review of randomised controlled trials (2014) · cites this paper as [41]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
The Global Deterioration Scale for assessment of primary degenerative dementia
Reisberg, ., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 4,982 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002) · JAMA · doi:10.1001/jama.288.12.1475 · Cited by 2,049 · see citing works
The Neuropsychiatric Inventory
Cummings, J. L. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.10s · Cited by 2,017 · see citing works
Morris, J. N., Fries, B. E., & Morris, S. A. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.11.m546 · Cited by 1,408 · see citing works
Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works
Livingston, G., Johnston, K., Katona, C., Paton, J., Lyketsos, C. G., & Old Age Task Force of the World Federation of Biological Psychiatry (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.1996 · Cited by 591 · cited 1× · see citing works
“Comorbidity (recuperation from an acute illness) can also influence QoL and was not considered as an independent variable. Additionally, although NPI-NH factors were believed to be independent from each other, some of the explained variance might be due to a moderate correlation between them. Notably, correlations bet…”
BackgroundBallard, C., Hanney, M. L., Theodoulou, M., Douglas, S., McShane, R., Kossakowski, K., Gill, R., Juszczak, E., Yu, L.-M., & Jacoby, R. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70295-3 · Cited by 567 · see citing works
Wood, S. A., Cummings, J. L., Hsu, M., Barclay, T. R., Wheatley, M. V., Yarema, K. T., & Schnelle, J. F. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200002000-00010 · Cited by 490 · see citing works
Selbæk, G., Kirkevold, Ø., & Engedal, K. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1749 · Cited by 369 · see citing works
Banerjee, S. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.072983 · Cited by 352 · see citing works
Neuropsychiatric Symptoms and Quality of Life in Alzheimer Disease
Shin, I. S., Carter, M., Masterman, D. L., Fairbanks, L. A., & Cummings, J. L. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.6.469 · Cited by 321 · see citing works
Quality of life of people with dementia in residential care homes
Hoe, J., Hancock, G. A., Livingston, G., & Orrell, M. W. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.104.007658 · Cited by 282 · see citing works
Zuidema, S. U., Derksen, E. W. C., Verhey, F. R. J., & Koopmans, R. T. C. M. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1722 · Cited by 275 · see citing works
Self-citationDementia Care and Quality of Life in Assisted Living and Nursing Homes
Zimmerman, S. I., Sloane, P. D., Williams, C. S., Reed, P. S., Preisser, J. S., Eckert, J. K., Boustani, M. A., & Dobbs, D. (2005) · The Gerontologist · doi:10.1093/geront/45.suppl_1.133 · Cited by 246 · see citing works
Dementia patients caregivers quality of life: the PIXEL study
Thomas, P., Lalloué, F., Preux, P., Hazif‐Thomas, C., Pariel, S., Inscale, R., Belmin, J., & Clément, J. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1422 · Cited by 235 · see citing works
Use of the QOL-AD for measuring quality of life in people with severe dementia—the LASER-AD study
Hoe, J., Katona, C., Roch, B., & Livingston, G. (2005) · Age and Ageing · doi:10.1093/ageing/afi030 · Cited by 230 · see citing works
QUALIDEM: development and evaluation of a dementia specific quality of life instrument––validation
Ettema, T. P., Dröes, R., de Lange, J., Mellenbergh, G. J., & Ribbe, M. W. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1692 · Cited by 225 · see citing works
Ettema, T. P., Dröes, R., de Lange, J., Mellenbergh, G. J., & Ribbe, M. W. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1713 · Cited by 221 · see citing works
Aalten, P., Verhey, F. R. J., Boziki, M. K., Brugnolo, A., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111082 · Cited by 207 · see citing works
Self-citationBallard, C. G., O'Brien, J. T., James, I. A., Mynt, P., Lana, M. M., Potkins, D., Reichelt, K., Lee, L., Swann, A., & Fossey, J. (2001) · International Psychogeriatrics · doi:10.1017/s1041610201007499 · Cited by 173 · see citing works
m, F. B., Jönsson, L., Minthon, L., & Londos, E. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318065c4a9 · Cited by 172 · see citing works
Evaluating the Quality of Life of Long-Term Care Residents With Dementia
Sloane, P. D., Zimmerman, S. I., Williams, C. S., Reed, P. S., Gill, K., & Preisser, J. S. (2005) · The Gerontologist · doi:10.1093/geront/45.suppl_1.37 · Cited by 172 · see citing works
The concept of quality of life in dementia in the different stages of the disease
Ettema, T. P., Dröes, R., de Lange, J., Ooms, M. E., Mellenbergh, G. J., & Ribbe, M. W. (2005) · International Psychogeriatrics · doi:10.1017/s1041610205002073 · Cited by 167 · see citing works
Samus, Q. M., Rosenblatt, A., Steele, C., Baker, A. S., Harper, M. G., Brandt, J., Mayer, L. S., Rabins, P. V., & Lyketsos, C. G. (2005) · The Gerontologist · doi:10.1093/geront/45.suppl_1.19 · Cited by 155 · see citing works
Zwakhalen, S. M. G., Koopmans, R. T. C. M., Geels, P. J. E. M., Berger, M. P. F., & Hamers, J. P. H. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.02.009 · Cited by 150 · see citing works
Self-citationKat, M. G., de Jonghe, J. F. M., Aalten, P., Kalisvaart, K. J., Dröes, R., & Verhey, F. R. J. (2002) · PubMed · Cited by 124 · see citing works
Self-citationZuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000105603 · Cited by 109 · see citing works
Self-citationPrevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia
Nijk, R., Zuidema, S. U., & Koopmans, R. T. C. M. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209008916 · Cited by 107 · see citing works
Self-citationWinzelberg, G. S., Williams, C. S., Preisser, J. S., Zimmerman, S. I., & Sloane, P. D. (2005) · The Gerontologist · doi:10.1093/geront/45.suppl_1.106 · Cited by 107 · see citing works
Cipher, D. J., & Clifford, P. A. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1155 · Cited by 102 · see citing works
Smalbrugge, M., Jongenelis, L. K., Pot, A. M., Beekman, A. T. F., & Eefsting, J. A. (2007) · BMC Geriatrics · doi:10.1186/1471-2318-7-3 · Cited by 95 · see citing works
Missotten, P., Squelard, G., Ylieff, M., Notte, D. D., Paquay, L., Lepeleire, J. D., & Fontaine, O. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1981 · Cited by 85 · see citing works
Zunzunegui, M. V., Cuadra, P. G., B�land, F., del Ser, T., & Wolfson, C. M. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(200002)15:2 · Cited by 85 · see citing works
A pilot study of the relationship between discomfort and agitation in patients with dementia
Buffum, M. D., Miaskowski, C. A., Sands, L. P., & Brod, M. I. (2001) · Geriatric Nursing · doi:10.1067/mgn.2001.115196 · Cited by 85 · see citing works
Edvardsson, D., Sandman, P. O., Nay, R., & Karlsson, S. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208006716 · Cited by 76 · see citing works
Bouman, A. I. E., Ettema, T. P., Wetzels, R. B., van Beek, A. P. A., de Lange, J., & Dröes, R. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2585 · Cited by 75 · see citing works
Self-citationAssessing quality of life in Taiwanese patients with Alzheimer's disease
Fuh, J., & Wang, S. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1425 · Cited by 74 · see citing works
Apathy in Dementia: Relations with Depression, Functional Competence, and Quality of Life
Yeager, C. A., & Hyer, L. A. (2008) · Psychological Reports · doi:10.2466/pr0.102.3.718-722 · Cited by 70 · see citing works
Development of a Short Form of the Severe Impairment Battery
Saxton, J. A. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.999 · Cited by 63 · see citing works
Estimating the Prevalence of Agitation in Community-Dwelling Persons With Alzheimer's Disease
Tractenberg, R. E., Weiner, M., & Thal, L. J. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.1.11 · Cited by 50 · see citing works
Comorbid Psychosocial Symptoms and Quality of Life in Patients With Dementia
Snow, A. L., Dani, R. N., Souchek, J., Sullivan, G., Ashton, C. M., & Kunik, M. E. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200505000-00008 · Cited by 43 · see citing works
Ballard, C. G., & Margallo‐Lana, M. (2004) · PubMed · Cited by 37 · see citing works
Validity of the Severe Impairment Battery Short Version
de Jonghe, J. F. M., Wetzels, R. B., Mulders, A., Zuidema, S. U., & Koopmans, R. T. C. M. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.163220 · Cited by 30 · see citing works
Self-citationGerritsen, D. L., Ooms, M. E., Steverink, N., Frijters, D. H. M., Bezemer, D., & Ribbe, M. W. (2004) · PubMed · Cited by 29 · see citing works
Furåker, C., & NILSSON, A. (2009) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2008.01347.x · Cited by 28 · see citing works
Zuidema, S. U., van Iersel, M. B., Koopmans, R. T. C. M., Verhey, F. R. J., & Rikkert, M. G. M. O. (2006) · PubMed · Cited by 25 · see citing works
Self-citationQuality of Life in Dementia: Do Professional Caregivers Focus on the Significant Domains?
Gerritsen, D. L., Ettema, T. P., Knoop, E. C. C. B.-V. D., Bos, J., Hoogeveen, F. R., de Lange, J., Meihuizen, L., Schölzel-Dorenbos, C. J. M., & Dröes, R. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507299771 · Cited by 25 · see citing works
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Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477087 · Cited by 2,773 · see citing works
Self-citationAbraha, I., Rimland, J. M., Trotta, F. M., Dell'Aquila, G., Cruz-Jentoft, A., Petrovic, M., Gudmundsson, A., Soiza, R., O'Mahony, D., Guaita, A., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-012759 · Cited by 557 · see citing works
Livingston, G., Kelly, L., Lewis-Holmes, E., Baio, G., Morris, S., Patel, N., Omar, R. Z., Katona, C., & Cooper, C. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.141119 · Cited by 426 · see citing works
Martyr, A., Nelis, S. M., Quinn, C., Wu, Y., Lamont, R. A., Henderson, C., Clarke, R., Hindle, J. V., Thom, J. M., Jones, I. R., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718000405 · Cited by 308 · see citing works
Ballard, C., Corbett, A., Orrell, M., Williams, G., Moniz-Cook, E., Romeo, R., Woods, B., Garrod, L., Testad, I., Woodward-Carlton, B., et al. (2018) · PLOS Medicine · doi:10.1371/journal.pmed.1002500 · Cited by 263 · see citing works
Livingston, G., Kelly, L., Lewis-Holmes, E., Baio, G., Stephen Morris, A., Patel, N. V., Omar, R., Katona, C., & Cooper, C. (2014) · Health Technology Assessment · doi:10.3310/hta18390 · Cited by 244 · see citing works
Beerens, H. C., Zwakhalen, S. M. G., Verbeek, H., Ruwaard, D., & Hamers, J. P. H. (2013) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2013.02.005 · Cited by 219 · see citing works
Individual music therapy for agitation in dementia: an exploratory randomized controlled trial
Ridder, H. M. O., Stige, B., Qvale, L. G., & Gold, C. (2013) · Aging & Mental Health · doi:10.1080/13607863.2013.790926 · Cited by 226 · see citing works
Majić, T., Gutzmann, H., Heinz, A., Lang, U. E., & Rapp, M. A. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.03.004 · Cited by 172 · see citing works
Jing, W., Willis, R. F., & Feng, Z. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.04.009 · Cited by 163 · see citing works
Course of Neuropsychiatric Symptoms in Residents with Dementia in Nursing Homes Over 2-Year Period
Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f60fa1 · Cited by 158 · see citing works
Self-citationLivingston, G., Barber, J., Marston, L., Rapaport, P., Livingston, D., Cousins, S., Robertson, S., La Frenais, F., & Cooper, C. (2017) · BJPsych Open · doi:10.1192/bjpo.bp.117.005181 · Cited by 148 · see citing works
Leng, M., Liu, P., Zhang, P., Hu, M., Zhou, H., Li, G., Yin, H., & Chen, L. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.032 · Cited by 122 · see citing works
Rokstad, A. M. M., Røsvik, J., Kirkevold, Ø., Selbæk, G., Benth, J. Š., & Engedal, K. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000354366 · Cited by 121 · see citing works
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Mühlbauer, V., Möhler, R., Dichter, M. N., Zuidema, S. U., Köpke, S., & Luijendijk, H. J. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013304.pub2 · Cited by 117 · see citing works
Self-citationZubritsky, C. D., Abbott, K. H., Hirschman, K. B., Bowles, K. H., Foust, J. B., & Naylor, M. D. (2012) · The Gerontologist · doi:10.1093/geront/gns093 · Cited by 115 · see citing works
Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial
Henskens, M., Nauta, I. M., van Eekeren, M. C. A., & Scherder, E. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000491818 · Cited by 114 · see citing works
Quality of Life among Elderly Patients with Dementia in Institutions
Barca, M. L., Engedal, K., Laks, J., & Selbæk, G. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000328969 · Cited by 114 · see citing works
Baker, F. A., Lee, C., Sousa, T. V., Stretton-Smith, P. A., Tamplin, J., Sveinsdóttir, V. Ó., Geretsegger, M., Wake, J. D., Aßmus, J., & Gold, C. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00027-7 · Cited by 101 · see citing works
Cahill, S. M., & Diaz-Ponce, A. M. (2011) · Aging & Mental Health · doi:10.1080/13607863.2010.551342 · Cited by 100 · see citing works
Environmental Determinants of Quality of Life in Nursing Home Residents with Severe Dementia
Garre‐Olmo, J., López‐Pousa, S., Turon‐Estrada, A., Juvinyà, D., Ballester, D., & Vilalta‐Franch, J. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04040.x · Cited by 104 · see citing works
Winter, Y., Korchounov, A., Zhukova, T. V., & Epifanova-Bertschi, N. (2011) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.80087 · Cited by 85 · see citing works
Leontjevas, R., Gerritsen, D. L., Koopmans, R. T. C. M., Smalbrugge, M., & Vernooij-Dassen, M. J. F. J. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.03.006 · Cited by 71 · see citing works
Self-citationVariables associated to quality of life among nursing home patients with dementia
Mjørud, M., Kirkevold, M., Røsvik, J., Selbæk, G., & Engedal, K. (2014) · Aging & Mental Health · doi:10.1080/13607863.2014.903468 · Cited by 72 · see citing works
Klapwijk, M. S., Caljouw, M. A. A., Pieper, M. J. C., van der Steen, J. T., & Achterberg, W. P. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000448806 · Cited by 70 · see citing works
Henskens, M., Nauta, I. M., Drost, K. T., & Scherder, E. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s160031 · Cited by 64 · see citing works
Hu, M., Zhang, P., Leng, M., Li, C., & Chen, L. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.016 · Cited by 60 · see citing works
Helvik, A., Selbæk, G., Benth, J. Š., Røen, I., & Bergh, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206147 · Cited by 59 · see citing works
Anatchkova, M., Brooks, A., Swett, L., Hartry, A., Duffy, R. A., Baker, R. A., Hammer-Helmich, L., & Aigbogun, M. S. (2019) · International Psychogeriatrics · doi:10.1017/s1041610218001898 · Cited by 56 · see citing works
Andrieu, S., Coley, N., Rolland, Y., Cantet, C., Arnaud, C., Guyonnet, S., Nourhashémi, F., Grand, A., Vellas, B. J., & PLASA group (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.09.003 · Cited by 52 · see citing works
Schüssler, S., Dassen, T. W. N., & Lohrmann, C. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0298-8 · Cited by 52 · see citing works
Haugland, V. L., & Reime, M. H. (2018) · Nurse Education in Practice · doi:10.1016/j.nepr.2018.08.008 · Cited by 53 · see citing works
Quality of life in people with cognitive impairment: nursing homes versus home care
Nikmat, A. W., Al-Mashoor, S. H. A., & Hashim, N. A. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214002609 · Cited by 49 · see citing works
van de Ven‐Vakhteeva, J., Bor, H. H. J., Wetzels, R. B., Koopmans, R. T. C. M., & Zuidema, S. U. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3858 · Cited by 48 · see citing works
Self-citationMjørud, M., Røsvik, J., Rokstad, A. M. M., Kirkevold, M., & Engedal, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115248 · Cited by 46 · see citing works
Leontjevas, R., Gerritsen, D. L., Vernooij-Dassen, M. J. F. J., Smalbrugge, M., & Koopmans, R. T. C. M. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318233152b · Cited by 45 · see citing works
Self-citationSimmons, S. F., Bonnet, K. R., Hollingsworth, E. K., Kim, J., Powers, J. S., Habermann, R., NEWHOUSE, P. A., & Schlundt, D. G. (2017) · The Gerontologist · doi:10.1093/geront/gnx083 · Cited by 47 · see citing works
Change and predictors of quality of life in institutionalized older adults with dementia
de Castro-Monteiro, E., Forjaz, M. J., Ayala, A., Rodríguez‐Blázquez, C., Fernández‐Mayoralas, G., Díaz-Redondo, A., & Martínez‐Martín, P. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0706-8 · Cited by 44 · see citing works
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Mühlbauer, V., Luijendijk, H. J., Dichter, M., Mohler, R. A., Zuidema, S. U., & Köpke, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013304 · Cited by 42 · see citing works
Self-citationHenskens, M., Nauta, I. M., Vrijkotte, S., Drost, K. T., Milders, M. V., & Scherder, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223704 · Cited by 41 · see citing works
Quality of life in people living with dementia in nursing homes
Moyle, W., & O’Dwyer, S. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835a1ccf · Cited by 39 · see citing works
Røen, I., Selbæk, G., Kirkevold, Ø., Engedal, K., Lerdal, A., & Bergh, S. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437093 · Cited by 39 · see citing works
Quality of life (QoL) in community-dwelling and institutionalized Alzheimer's disease (AD) patients
León‐Salas, B., Olazarán, J., Cruz, I., Agüera-Ortíz, L., Dobato, J. L., Valentí, M., Múñiz, R., González-Salvador, T., & Martínez‐Martín, P. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.04.013 · Cited by 39 · see citing works
Dichter, M., Dortmann, O., Halek, M., Meyer, G., Holle, D., Nordheim, J., & Bartholomeyczik, S. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-91 · Cited by 38 · see citing works
Lalic, S., Jamsen, K. M., Wimmer, B. C., Tan, E. C. K., Hilmer, S. N., Robson, L., Emery, T., & Bell, J. S. (2016) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2075-4 · Cited by 36 · see citing works
Verloo, H., Salina, A. E., Fiorentino, A., & Cohen, C. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s184329 · Cited by 37 · see citing works
Smeets, C. H. W., Smalbrugge, M., Zuidema, S. U., Derksen, E. W. C., de Vries, E., van der Spek, K., Koopmans, R. T. C. M., & Gerritsen, D. L. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.08.016 · Cited by 35 · see citing works
Self-citationGräske, J., Verbeek, H., Gellert, P. R., Fischer, T., Kuhlmey, A., & Wolf‐Ostermann, K. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0504-8 · Cited by 34 · see citing works
Almomani, F., McDowd, J. M., Bani‐Issa, W., & Al-Momani, M. O. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0461-2 · Cited by 33 · see citing works
Boekhorst, S. T., Depla, M. F. I. A., Francke, A. L., Twisk, J. W. R., Zwijsen, S. A., & Hertogh, C. M. P. M. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3831 · Cited by 32 · see citing works
Liu, K. Y., Reeves, S., McAleese, K. E., Attems, J., Francis, P. T., Thomas, A. J., & Howard, R. J. (2020) · Brain · doi:10.1093/brain/awaa315 · Cited by 31 · see citing works
Gustafsson, M. V., Isaksson, U., Karlsson, S., Sandman, P., & Lövheim, H. (2016) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2058-5 · Cited by 30 · see citing works
van Kooten, J., van der Wouden, J. C., Sikkes, S. A. M., Smalbrugge, M., Hertogh, C. M. P. M., & Stek, M. L. (2017) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000197 · Cited by 30 · see citing works
Characteristics of institutionalized young onset dementia patients – the BEYOnD study
Mulders, A., Zuidema, S. U., Verhey, F. R. J., Koopmans, R. T. C. M., Koopmans, R., & Rosness, T. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214001859 · Cited by 29 · see citing works
Self-citationNakrem, S., Stensvik, G.-T., Skjong, R. J., & Ostaszkiewicz, J. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-4034-0 · Cited by 31 · see citing works
Longitudinal evaluation of dementia care in German nursing homes: the “DemenzMonitor” study protocol
Palm, R., Köhler, K., Schwab, C. G. G., Bartholomeyczik, S., & Holle, B. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-123 · Cited by 28 · see citing works
Sarabia‐Cobo, C. (2014) · Revista da Escola de Enfermagem da USP · doi:10.1590/s0080-623420140000700008 · Cited by 28 · see citing works
Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.02.013 · Cited by 27 · see citing works
Self-citationRomeo, R., Zala, D., Knapp, M. R. J., Orrell, M. W., Fossey, J., & Ballard, C. G. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.08.010 · Cited by 27 · see citing works
Gräske, J., Meyer, S., Worch, A., & Wolf‐Ostermann, K. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0012-5 · Cited by 27 · see citing works
Apathy and health-related quality of life in nursing home residents
Nijsten, J. M. H., Leontjevas, R., Smalbrugge, M., Koopmans, R. T. C. M., & Gerritsen, D. L. (2018) · Quality of Life Research · doi:10.1007/s11136-018-2041-y · Cited by 26 · see citing works
Self-citationvan der Spek, K., Gerritsen, D. L., Smalbrugge, M., Nelissen-Vrancken, M. H. J. M. G., Wetzels, R. B., Smeets, C. H. W., Zuidema, S. U., & Koopmans, R. T. C. M. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-307 · Cited by 25 · see citing works
Self-citationMoyle, W., & Murfield, J. (2013) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/erp.12.84 · Cited by 25 · see citing works
Severity of Neuropsychiatric Symptoms in Nursing Home Residents
Helvik, A., Engedal, K., Wu, B., Benth, J. Š., Corazzini, K., Røen, I., & Selbæk, G. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000442250 · Cited by 25 · see citing works
Revisiting Quality of Life for Elders in Long-Term Care: An Integrative Review
Sullivan, L., & Asselin, M. E. (2013) · Nursing Forum · doi:10.1111/nuf.12030 · Cited by 24 · see citing works
Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia
Hvidsten, L., Engedal, K., Selbæk, G., Wyller, T. B., Bruvik, F. K., & Kersten, H. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000487263 · Cited by 24 · see citing works
Ballard, C. G., Orrell, M. W., Moniz-Cook, E. D., Woods, B. T., Whitaker, R., Corbett, A., Aarsland, D., Murray, J., Lawrence, V. C., Testad, I., et al. (2020) · Programme Grants for Applied Research · doi:10.3310/pgfar08060 · Cited by 24 · see citing works
Goyal, A. R., Bergh, S., Engedal, K., Kirkevold, M., & Kirkevold, Ø. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203773 · Cited by 23 · see citing works
Schmüdderich, K., Holle, D., Ströbel, A., Holle, B., & Palm, R. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03167-5 · Cited by 22 · see citing works
Choi, A., Martyr, A., Clare, L., Fossey, J., Khan, Z., McDermid, J., & Ballard, C. G. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.03.017 · Cited by 22 · see citing works
Quality of Life and Its Factors in Korean Elderly With Mild Cognitive Impairment
Kang, Y., & Lee, E. (2017) · Clinical Nursing Research · doi:10.1177/1054773817714561 · Cited by 22 · see citing works
Quality of Life in Advanced Dementia with Late Onset, Young Onset, and Very Young Onset
Hartmann, J., Roßmeier, C., Riedl, L., Dorn, B., Fischer, J., Slawik, T., Fleischhaker, M., Hartmann, F., Egert-Schwender, S., Kehl, V., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201302 · Cited by 21 · see citing works
Klapwijk, M. S., Caljouw, M. A. A., Pieper, M. J. C., Putter, H., van der Steen, J. T., & Achterberg, W. P. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4912 · Cited by 21 · see citing works
Appelhof, B., Bakker, C., de Vugt, M. E., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Teerenstra, S., Verhey, F. R. J., Zuidema, S. U., & Koopmans, R. T. C. M. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.12.032 · Cited by 20 · see citing works
Self-citationAttitudes of long-term care staff toward dementia and their related factors
Lee, J., Hui, E., Kng, C., & Auyeung, T. W. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001512 · Cited by 19 · see citing works
Mjørud, M., Kirkevold, M., Røsvik, J., & Engedal, K. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000356497 · Cited by 19 · see citing works
Factors Associated with Sustained Attention during an Activity Intervention in Persons with Dementia
Kolanowski, A. M., Bossen, A., Hill, N. L., Guzmán‐Vélez, E., & Litaker, M. S. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000338604 · Cited by 19 · see citing works
Morrison, R. A., Jesdale, B. M., Dube, C. E., Nunes, A. P., Bova, C., Liu, S., & Lapane, K. L. (2020) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000508096 · Cited by 18 · see citing works
Xing, Y., Qin, W., Li, F., Jia, X., & Jia, J. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000336600 · Cited by 17 · see citing works
Poststroke agitation and aggression and social quality of life: a case control study
Lau, C. G., Tang, W. K., Liu, X. X., Liang, H. J., Liang, Y., Wong, A., Mok, V., Ungvari, G. S., Wong, K. S., Kim, J. S., et al. (2016) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2016.1212564 · Cited by 18 · see citing works
Sizoo, E. M., Thunnissen, J. A., van Loon, A. M., Brederveld, C. L., Timmer, H., Hendriks, S. A., & Smalbrugge, M. (2022) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5693 · Cited by 18 · see citing works
Björk, S., Lövheim, H., Lindkvist, M., Wimo, A. B., & Edvardsson, D. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4714 · Cited by 17 · see citing works
Structural validity and internal consistency of the Qualidem in people with severe dementia
Arons, A. M. M., Wetzels, R. B., Zwijsen, S. A., Verbeek, H., van de Ven, G., Ettema, T. P., Koopmans, R. T. C. M., & Gerritsen, D. L. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217001405 · Cited by 17 · see citing works
Self-citationRodríguez‐Monforte, M., Bethell, J., Stewart, S., Chu, C. H., Escrig-Piñol, A., Gea‐Sánchez, M., & McGilton, K. S. (2020) · Journal of Nursing Management · doi:10.1111/jonm.13173 · Cited by 17 · see citing works
Quality of life in persons with mild cognitive impairment: a systematic review and meta-analysis
Gopalakrishnan, P., Tiwari, S., Ravishankar, N., & Krishnan, G. (2024) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2023-0093 · Cited by 16 · see citing works
Bužgová, R., Kozáková, R., Sikorová, L., & Jarošová, D. (2016) · Aging & Mental Health · doi:10.1080/13607863.2016.1220919 · Cited by 16 · see citing works
Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2018) · Aging & Mental Health · doi:10.1080/13607863.2018.1428935 · Cited by 15 · see citing works
Self-citationYuen, I., & Kwok, T. C. Y. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5063 · Cited by 15 · see citing works
Junge, S., Gellert, P. R., O’Sullivan, J. L., Möller, S., Voigt‐Antons, J., Kuhlmey, A., & Nordheim, J. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02418-4 · Cited by 14 · see citing works
Todri, J., Todri, A., & Lena, O. (2019) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000505397 · Cited by 14 · see citing works
Freund‐Levi, Y., Bloniecki, V., Auestad, B., Tysen-Bäckström, A. C., Lärksäter, M., & Aarsland, D. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000362204 · Cited by 14 · see citing works
den IJssel, J. C. L. V. D., Appelhof, B., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., Koopmans, R. T. C. M., & Bakker, C. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000941 · Cited by 14 · see citing works
Self-citationLiu, K. Y., Borissova, A., Mahmood, J., Elliott, T., Knowles, M., Bentham, P., Reeves, S., & Howard, R. J. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12157 · Cited by 13 · see citing works
Villeneuve, R., Meillon, C., Bergua, V., Tabué-Teguo, M., & Amieva, H. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-1434-2 · Cited by 13 · see citing works
Ito, E., Berge, L. I., Husebo, B. S., Nouchi, R., & Sandvik, R. K. N. M. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.03.028 · Cited by 13 · see citing works
Parlak, M. M., Tokgöz, S. A., Munis, Ö. B., Saylam, G., & Köse, A. (2022) · Neurology Asia · doi:10.54029/2022eeu · Cited by 13 · see citing works
Giebel, C. M., Sutcliffe, C., Guiteras, A. R., Arve, S., Hallberg, I. R., Soto, M. E., Zabalegui, A., Hamers, J. P. H., Saks, K., & Challis, D. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214002610 · Cited by 13 · see citing works
Habiger, T. F., Achterberg, W. P., Flo, E., & Husebo, B. S. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5067 · Cited by 12 · see citing works
Eikelboom, W. S., Koch, J., Beattie, E., Lautenschlager, N. T., Doyle, C., van den Berg, E., Papma, J. M., Anstey, K. J., & Mortby, M. E. (2022) · Aging & Mental Health · doi:10.1080/13607863.2022.2032597 · Cited by 12 · see citing works
AXS-05: an investigational treatment for Alzheimer’s disease-associated agitation
Ward, K. M., & Citrome, L. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2096006 · Cited by 12 · see citing works
- Authors
- Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M.
- Affiliations
- Radboud University Nijmegen (NL)
- Maastricht University Medical Centre (NL)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 29
- Issue
- 3
- Pages
- 189-197
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2073516783
- Cited by
- 178
- References
- 54
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 16 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 7 · 2014: 18 · 2013: 16 · 2012: 9
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Radboud Universiteit
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › General Health Professions › Geriatric Care and Nursing Homes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- quality of life, dementia, nursing home residents, neuropsychiatric symptoms, psychotropic drug use, agitation, depression, psychosis, psychomotor agitation, cognitive impairment, dementia severity, Global Deterioration Scale, activities of daily living
- MeSH terms
- Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Data Interpretation, Statistical, Dementia, Drug Utilization, Female, Humans, Length of Stay, Male, Middle Aged, Neuropsychological Tests, Nursing Homes, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotropic Drugs, Quality of Life, Regression Analysis, Sex Factors, Marital Status
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