Decreased natural killer cell activity in women with endometriosis
Abstract
Natural killer (NK) cell activity is characterized by the spontaneous capacity of lymphoid cells derived from nonimmunized hosts to recognize and lyse certain tumor cell lines, virus-infected cells and transplanted tumor cell lines. Endometriosis is characterized by implantation and proliferation of autologous ectopic tissue in the pelvic cavity. Therefore, we focused on examining NK cell activity in women with endometriosis. NK cell activity in peripheral blood from women with endometriosis was lower than in women without endometriosis. On the basis of this finding, we analyzed also the effect of peripheral sera of women with endometriosis on NK cell activity. In the presence of peripheral sera of women with endometriosis, NK cell activity was significantly suppressed as compared with the sera of women without endometriosis. The suppressive effect of sera of women with endometriosis on NK cell activity showed dose-dependent curves. These studies provide the speculation that natural immunity mediated by NK cells may modulate the development of endometrial implants.
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Natural killer activity is decreased in peritoneal fluid and in plasma of women with endometriosis, and after excision of deep endometriosis their activity remains low, whereas elevated CA-125 concentrations return to normal.
“The natural killer activity is decreased in PF and in plasma of women with endometriosis (103-105) and after excision of deep endometriosis their activity remains low, whereas elevated CA-125 concentrations return to normal (106).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [105]
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“NK cell activity in patients with endometriosis is significantly reduced and these effects can be mediated by factors present in serum (5) or in endometrial stroma cultures-conditioned medium (6).”
BackgroundDecreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis
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“Most studies have found that the numbers of cytotoxic NK cells are reduced in the PF and peripheral blood of endometriosis patients and that this is accompanied by an overall decrease in NK cell activity [14, 35–37].”
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“The sera of these patients contain an inhibiting factor against NK cells (Tanaka et al., 1992).”
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“with the majority showing some degree of NK-cell dysfunction (Oosterlynck et al., 1991, 1992; Vigano et al., 1991; Tanaka et al., 1992; Garzetti et al., 1993, 1995; Iwasaki et al., 1993; Wilson et al., 1994; Ho et al., 1995).”
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Génétique et épigénétique de l'endométriose : analyse des micro-ARNs et séquençage de familles
Abo, C. (2020) · theses.fr (ABES) · doi:10.70675/1f196b86zdff4z4171zaff3zba99042c1a5d
- Authors
- Tanaka, E., Sendo, F., Kawagoe, S., & Hiroi, M.
- Affiliations
- Yamagata University (JP)
- Venue
- Gynecologic and Obstetric Investigation
- Publisher
- S. Karger AG
- Published
- 2010-03-02
- Volume
- 34
- Issue
- 1
- Pages
- 27-30
- ISSN
- 0378-7346 (ISSN-L)
- 1423-002X
- OpenAlex
- W2091228964
- Cited by
- 76
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic and Obstetric Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- endometriosis, natural killer cells, NK cell cytotoxicity, natural immunity, peripheral blood lymphocytes, dose-dependent inhibition
- MeSH terms
- Cytotoxicity, Immunologic, Endometriosis, Female, Humans, Killer Cells, Natural, Uterine Neoplasms
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