Prominent Chemopreventive and Chemoenhancing Effects for Resveratrol: Unraveling Molecular Targets and the Role of C-Reactive Protein

El-Mowafy, A.M.; El-Mesery, M.E.; Salem, H.A.; Al-Gayyar, M.M.; Darweish, M.M.

doi:10.1159/000298821

Cited by 24Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesCancer and biochemical research

Prominent Chemopreventive and Chemoenhancing Effects for Resveratrol: Unraveling Molecular Targets and the Role of C-Reactive Protein

El-Mowafy, A.M., El-Mesery, M.E., Salem, H.A., Al-Gayyar, M.M., Darweish, M.M.·2010·Chemotherapy

DOI 10.1159/000298821

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Abstract

Background: Resveratrol (RSVL) claims health benefits that pertain to the consumption of red wine/grapes. We currently evaluated the chemopreventive effects of RSVL, as well as its possible chemoenhancing effects when given with cisplatin (CP), in the Ehrlich ascites carcinoma (EAC) solid tumor model. Further, we monitored concomitant changes in serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), leukocytic count (LC) and lipid peroxidation (measured as malondialdehyde, MDA). Results: EAC-bearing mice exhibited a markedly elevated LC (2 fold), CRP (11 fold) and MDA levels (2.7 fold). RSVL (20 or 40 mg/kg) elicited significant, dose-dependent reductions in tumor size (58 and 78%, respectively), as well as in LC (normalized), CRP (down to 2 fold), TNF-α (down to near control levels) and MDA levels (normalized). The chemopreventive effects for CP (55% reduction in cell growth) was significantly lower than that of RSVL (40 mg/kg, 79% inhibition). Interestingly, coadministration of RSVL (20 mg/kg) markedly enhanced the chemoprevention of CP. Correlation studies revealed a high degree of positive association between tumor growth and CRP (r = 0.89) and leukocytosis (r = 0.86), thus attesting to a diagnostic/prognostic role for CRP in this solid tumor. Conclusion: RSVL elicited remarkable cytotoxicity on its own and appreciably augmented those of CP as well. The extent of tumor progression in various mouse groups was highly reflected by CRP levels. RSVL acts prominently by reducing inflammatory cytokines, leukocytosis and oxidative stress.

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RSV is a well-known activator of SIRT1.
“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
From Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016) · cites this paper as [37]
RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo.
“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
From Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016) · cites this paper as [37]

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Authors: El-Mowafy, A. M., El-Mesery, M. E., Salem, H. A., Al-Gayyar, M. M., & Darweish, M. M.
Affiliations: Mansoura University (EG)
ORCID: Salem, H.A.
Al-Gayyar, M.M.
Venue: Chemotherapy
Publisher: S. Karger AG
Published: 2010
Volume: 56
Issue: 1
Pages: 60-65
ISSN: 0009-3157 (ISSN-L)
1421-9794
DOI: 10.1159/000298821
OpenAlex: W2041490167
Cited by: 24
References: 40
Citations by year: 2023: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 2
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Chemotherapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: resveratrol, chemoprevention, cisplatin, Ehrlich ascites carcinoma, C-reactive protein, TNF-α, leukocytosis, lipid peroxidation, malondialdehyde, oxidative stress, inflammation, red wine, solid tumors, prognostic factors
MeSH terms: Resveratrol, Animals, Antineoplastic Combined Chemotherapy Protocols, C-Reactive Protein, Carcinoma, Ehrlich Tumor, Cisplatin, Female, Leukocyte Count, Malondialdehyde, Stilbenes, Tumor Necrosis Factor-alpha, Anticarcinogenic Agents, Mice

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Prominent Chemopreventive and Chemoenhancing Effects for Resveratrol: Unraveling Molecular Targets and the Role of C-Reactive Protein

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