Cited by 32Clinical Nutrition and GastroenterologyAcute Kidney Injury ResearchDialysis and Renal Disease Management

Amino Acid Balance with Extended Daily Diafiltration in Acute Kidney Injury

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Chua, Horng Ruey, Baldwin, Ian, Fealy, Nigel, Naka, Toshio, Bellomo, Rinaldo·2012·Blood Purification

Abstract

Background: The impact of hybrid dialysis therapies on amino acid (AA) balance in critically ill patients with acute kidney injury is unknown. Methods: We examined prospectively the AA balance with extended daily diafiltration (EDDF). Results: We studied 7 patients. AA clearances with EDDF ranged from 21.6 ml/min (tryptophan) to 66.9 ml/min (taurine). AA loss was 4.2 (IQR 1.4–12.3) g/day and 4.5% of daily protein intake for patients on enteral nutrition (EN). Percentage AA loss per hour on EDDF was highest for glutamine (32.1%) and lowest for glutamic acid (0.8%). Blood AA levels correlated with corresponding EDDF losses. Median total nitrogen appearance was 25.0 (IQR 20.6–29.3) g/day for patients on EN. This resulted in a negative nitrogen balance of –10.7 (IQR –16.6 to –1.4) g/day, of which 6.5% was attributable to AA loss. Conclusions: AA loss with EDDF was limited, but with much individual variability, and contributed to a strongly negative daily nitrogen balance.

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Crossref · 10.1159/000335607

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  • Enteral GLN has also proven to improve body composition and in particular lean body mass in a group of 44 head and neck cancer patients randomized to receive a GLN supplement (30 g daily) for four weeks.

    “Finally, enteral GLN has also proven to improve body composition and in particular lean body mass in a group of 44 head and neck cancer patients randomized to receive a GLN supplement (30 g daily) for four weeks (220).”
  • The authors observed a significant improvement of fat-free mass, serum albumin, and quality of life scores postoperatively.

    “The authors observed a significant Improvement of fat-free mass, serum albumin, and quality of life scores postoperatively (220).”

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Authors
Chua, H. R., Baldwin, I., Fealy, N., Naka, T., & Bellomo, R.
Affiliations
Austin Hospital (AU)
Venue
Blood Purification
Publisher
S. Karger AG
Published
2012
Volume
33
Issue
4
Pages
292-299
ISSN
  • 0253-5068 (ISSN-L)
  • 1421-9735
OpenAlex
W2022065329
Cited by
32
References
20
Citations by year
2025: 3 · 2024: 5 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • Blood Purification (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
amino acid balance, acute kidney injury, amino acid loss, nitrogen balance, enteral nutrition, critically ill patients, glutamine, taurine, tryptophan, blood amino acid levels
MeSH terms
Adult, Aged, Aged, 80 and over, Amino Acids, Enteral Nutrition, Female, Renal Dialysis, Humans, Male, Middle Aged, Nitrogen, Dialysis Solutions, Critical Illness, Acute Kidney Injury

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