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Cited by 3,253

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Open access
Yang, Ying, Li, Shuping, Yang, Qiao, Shi, Yu, Zheng, Min, Liu, Yanning, Chen, Feng, Song, Guangzhong, Xu, Hangdi, Wan, Tianhong, He, Jiliang, Chen, Zhi·2014·Cellular Physiology and Biochemistry
DOI 10.1159/000358696
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Abstract

BACKGROUND: Resveratrol (Res) is a polyphenol anti-inflammatory agent. We have studied the link between the anti-inflammatory effects of Res and the high mobility group box 1(HMGB1) signaling pathway. METHODS: Murine macrophage-like RAW264.7 cells (RAW264.7 cells) were either untreated (control) or treated with Res, LPS, or LPS + Res. Levels of IL-6, NO, and TNF-α were measured by ELISA and colorimetric assays. Expression of HMGB1 was detected by qRT-PCR, western blot, and immunofluorescence assays. Protein and mRNA expression levels of TLR4 were also examined. RESULTS: Res significantly reduced the levels of IL-6, NO, and TNF-α in RAW264.7 cells exposed to LPS. Expression levels of HMGB1 (mRNA and protein) and of TLR4 in the LPS + Res-treated cells were lower than in cells treated with LPS alone. CONCLUSIONS: Res can block the inflammatory effects induced by LPS in RAW264.7 cells. Down-regulation of HMGB expression may be one of the mechanisms of action of Res. Res may also influence TLR4 expression in the HMGB1-TLR4 signaling pathway.

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Metadata

Authors
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., He, J., & Chen, Z.
Venue
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Published
2014
Volume
33
Issue
5
Pages
1283-1292
ISSN
  • 1015-8987 (ISSN-L)
  • 1421-9778
DOI
10.1159/000358696
OpenAlex
W1994190235
Cited by
3,253
References
5
FWCI
168.17
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells. https://app.cochat.ai/papers/10.1159/000358696
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Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., He, J., & Chen, Z. (2014). Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells. Cellular Physiology and Biochemistry. https://doi.org/10.1159/000358696

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