A Direction for Clinical Radiation Pathology

Rubin, P.; Casarett, G.

doi:10.1159/000392794

Cited by 133Radiology practices and educationAdvances in Oncology and RadiotherapyEffects of Radiation Exposure

A Direction for Clinical Radiation Pathology

Rubin, P., Casarett, G.·2015·Frontiers of radiation therapy and oncology

DOI 10.1159/000392794

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1159/000392794

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

These resources present normal-tissue dose limits in terms of TD5/5 and TD50/5, the total doses associated with a complication rate of 5% and 50% within 5 years, respectively, as introduced by Rubin and Cassarett in 1972.
“These resources present normaltissue dose limits in terms of TD5/5 and TD50/5, the total doses associated with a complication rate of 5% and 50% within 5 y, respectively, as introduced by Rubin and Cassarett in 1972 ( 27 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [27]

Sorted by citations

Tolerance of normal tissue to therapeutic irradiation
Emami, B., Lyman, J., Brown, A., Cola, L., Goitein, M., Munzenrider, J. E., Shank, B., Solin, L. J., & Wesson, M. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90171-y · Cited by 4,488 · see citing works
“From the pioneering work of Rubin and Cassarett, to the monumental work by Emami et al. and now the exhaustive review by QUANTEC, great progress has been made in the field of normal tissue tolerance to therapeutic radiation.”
BackgroundInfluential
ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604 · see citing works
The cardiotoxicity of adriamycin and daunomycin in children
Gilladoga, A. C., Manuel, C., TAN, C. T. C., Wollner, N., Sternberg, S. S., & Murphy, M. L. (1976) · Cancer · doi:10.1002/1097-0142(197602)37:2+ · Cited by 171 · see citing works
Self-citation
Autoradiography of cellular glycoproteins reveals histogenesis of bronchogenic adenocarcinomas
Dermer, G. B. (1981) · Cancer · doi:10.1002/1097-0142(19810415)47:8 · Cited by 8 · see citing works
Parotid gland function during and following radiotherapy of malignancies in the head and neck
Franzén, L., Funegård, U., Ericson, T., & Henriksson, R. (1992) · European Journal of Cancer · doi:10.1016/s0959-8049(05)80076-0 · Cited by 244 · see citing works
Classification of radiation effects for dose limitation purposes: history, current situation and future prospects
Hamada, N., & FUJIMICHI, Y. (2014) · Journal of Radiation Research · doi:10.1093/jrr/rru019 · Cited by 228 · see citing works
“The number ‘1–5%’ appears to originate from the proposal by Rubin and Casarett [24], who defined a clinically acceptable minimum injurious tolerance dose, as a dose that causes severe complications in ‘1–5%’ of patients within 5 years post-radiotherapy.”
Background
Long-term effects of radiotherapy on taste and salivary function in man
Mossman, K. L., Shatzman, A. R., & Chencharick, J. D. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90166-3 · Cited by 186 · see citing works
The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence
Deschner, E. E., Lytle, J. S., Wong, G. Y., Ruperto, J. F., & Newmark, H. L. (1990) · Cancer · doi:10.1002/1097-0142(19901201)66:11 · Cited by 96 · see citing works
Pathologic changes secondary to radiation
BERTHRONG, M. (1986) · World Journal of Surgery · doi:10.1007/bf01658133 · Cited by 137 · see citing works
Cronic radiation proctitis
Tagkalidis, P. P., & Tjandra, J. J. (2001) · ANZ Journal of Surgery · doi:10.1046/j.1440-1622.2001.02081.x · Cited by 115 · see citing works
Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model.
Kehwar, T. (2005) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.19597 · Cited by 104 · see citing works
Radiation tolerance of the vaginal mucosa
Hintz, B. L., Kagan, A. R., Chan, P., et al. (1980) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(80)90227-8 · Cited by 98 · see citing works
Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95 · see citing works
“These resources present normaltissue dose limits in terms of TD5/5 and TD50/5, the total doses associated with a complication rate of 5% and 50% within 5 y, respectively, as introduced by Rubin and Cassarett in 1972 (27).”
Background
Late effects of radiation therapy in pediatric patients and survivorship
Palmer, J. D., Tsang, D. S., Tinkle, C. L., Olch, A. J., Kremer, L. C. M., Ronckers, C. M., Gibbs, I. C., & Constine, L. S. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28349 · Cited by 92 · see citing works
The Surgical Management of the Radiation-Injured Intestine
Marks, G. J., & Mohiudden, M. (1983) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)42931-2 · Cited by 79 · see citing works
Individualizing cancer treatment: biological optimization models in treatment planning and delivery
Brahme, A. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)01501-7 · Cited by 76 · see citing works
Estimation of Long-Term Salivary Gland Damage Induced by Radiotherapy
Makkonen, T. A., & Nordman, E. (1987) · Acta Oncologica · doi:10.3109/02841868709089980 · Cited by 67 · see citing works
Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity
Henriksson, R., Fröjd, Ö., Gustafsson, H., et al. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.58 · Cited by 65 · see citing works
3-D comparative study of proton vs. x-ray radiation therapy for rectal cancer
Tatsuzaki, H., Urie, M. M., & Willett, C. G. (1992) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(92)90056-n · Cited by 64 · see citing works
Laser Therapy for Severe Radiation-Induced Rectal Bleeding
Ahlquist, D. A., Gostout, C. J., Viggiano, T. R., et al. (1986) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62631-7 · Cited by 61 · see citing works
Radiation-induced hyposalivation and its treatment with oral pilocarpine
Niedermeier, W., Matthaeus, C., Meyer, C., et al. (1998) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/s1079-2104(98)90343-2 · Cited by 56 · see citing works
Complications in the treatment of small cell carcinoma of the lung
Feld, R. D. (1981) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(81)80003-5 · Cited by 54 · see citing works
Breast Hypoplasia Following Irradiation of the Female Breast in Infancy and Early Childhood
Fürst, C. J., Lundell, M., Ahlbäck, S.-O., et al. (1989) · Acta Oncologica · doi:10.3109/02841868909092262 · Cited by 48 · see citing works
Oral implant rehabilitation in irradiated patients without adjunctive hyperbaric oxygen.
Andersson, G., Andréasson, L., & Bjelkengren, G. (1998) · PubMed · Cited by 46 · see citing works
Treatment of Radiation Injury
Akita, S. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0403 · Cited by 45 · see citing works
“8–2 Gy.(8) Data were collected of the predicted TD, which was related to a 5% rate of complications within 5 years (TD5/5) of the maximum TD, TD50/5, which caused a 50% complication rate by 5 years.”
Influential
Radiation-Induced Lesions of the Brachial Plexus Correlated to the Dose-Time-Fraction Schedule
Svensson, H., Westling, P., & Larsson, L. (1975) · Acta Radiologica Therapy Physics Biology · doi:10.3109/02841867509132663 · Cited by 44 · see citing works
Objective measurements of radiotherapy‐induced erythema
Nyström, J., Geladi, P. L. M., Lindholm‐Sethson, B., et al. (2004) · Skin Research and Technology · doi:10.1111/j.1600-0846.2004.00078.x · Cited by 39 · see citing works
“The late side-effects occur months or even years after treatment and depend mainly on disturbances of the microvasculature and connective tissues and can even be irreversible (5).”
Background
The Principles and Practice of Re-irradiation in Clinical Oncology: An Overview
Dörr, W., & Gabryś, D. (2017) · Clinical Oncology · doi:10.1016/j.clon.2017.11.014 · Cited by 38 · see citing works
Correlation of intraoperatively irradiated volume and fibrosis in patients with soft-tissue sarcoma of the extremities
van Kampen, M., Eble, M. J., Lehnert, T., et al. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01620-0 · Cited by 38 · see citing works
Methods for extracting dose response curves from radiation therapy data, I: A unified approach
Herring, D. F. (1980) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(80)90042-5 · Cited by 37 · see citing works
Radiation tolerance of the pig kidney: A model for determining overall time and fraction factors for preserving renal function
Hopewell, J. W., & Berry, R. J. (1975) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(75)90010-3 · Cited by 37 · see citing works
Relative Radiosensitivities of the Small and Large Intestine
Becciolini, A. (1987) · Advances in radiation biology · doi:10.1016/b978-0-12-035412-2.50006-0 · Cited by 37 · see citing works
Prevention and Therapy of Radiation-Induced Bowel Discomfort
Henriksson, R., Franzén, L., & Littbrand, B. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209093223 · Cited by 36 · see citing works
Maxillo-facial Aspects of Radiation Protection, Focused on Recent Research regarding Critical Organs
Bengtsson, G. (1978) · Dentomaxillofacial Radiology · doi:10.1259/dmfr.1978.0001 · Cited by 34 · see citing works
Oral findings in irradiated edentulous patients
Bernhoft, C., & Skaug, N. (1985) · International Journal of Oral Surgery · doi:10.1016/s0300-9785(85)80074-0 · Cited by 32 · see citing works
Use of an Image-Guided Robotic Radiosurgery System for the Treatment of Canine Nonlymphomatous Nasal Tumors
Glasser, S. A., Charney, S. C., Dervisis, N. G., et al. (2014) · Journal of the American Animal Hospital Association · doi:10.5326/jaaha-ms-6024 · Cited by 31 · see citing works
Effet volume en radiothérapie [II]. Deuxième partie : volume et tolérance des tissus sains
Huchet, A., Caudry, M., Belkacémi, Y., et al. (2003) · Cancer/Radiothérapie · doi:10.1016/s1278-3218(03)00082-9 · Cited by 31 · see citing works
Noncancer Effects of Ionizing Radiation Exposure on the Eye, the Circulatory System and beyond: Developments made since the 2011 ICRP Statement on Tissue Reactions
Hamada, N. (2023) · Radiation Research · doi:10.1667/rade-23-00030.1 · Cited by 30 · see citing works
“cause an effect in “at least 1–5%” of exposed individuals (11) where “1–5%” may stem from the clinical tolerance dose concept (19).”
Background
Animal models of radiation retinopathy – From teletherapy to brachytherapy
Ramos, M. S., Echegaray, J. J., Kuhn‐Asif, S. E., et al. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.01.019 · Cited by 27 · see citing works
Relative Radiosensitivity of the Human Lung
Travis, E. L. (1987) · Advances in radiation biology · doi:10.1016/b978-0-12-035412-2.50009-6 · Cited by 26 · see citing works
Hyperbaric oxygen in radiation therapy
Glassburn, J. R., Brady, L. W., & Plenk, H. P. (1977) · Cancer · doi:10.1002/1097-0142(197702)39:2+ · Cited by 32 · see citing works
Self-citation
Radiation myelitis following craniospinal irradiation with concurrent actinomycin‐D therapy
Littman, P., Rosenstock, J. G., & Bailey, C. C. (1978) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950050121 · Cited by 25 · see citing works
Assessment of saliva and oral candidiasis levels 12, 24 and 36 months after radiotherapy in patients with head and neck cancer
Boñar-Álvarez, P., Padín-Iruegas, E., Chamorro-Petronacci, C. M., et al. (2020) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2020.09.016 · Cited by 24 · see citing works
Late effects of radiation on the mouse kidney
Jordan, S. W., Key, C. R., Gomez, L. S., et al. (1978) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(78)90031-x · Cited by 24 · see citing works
New Approach for Treatment of Vertebral Metastases Using Intensity-Modulated Radiotherapy*
Inoue, T., Oh, R., & Shiomi, H. (2011) · Strahlentherapie und Onkologie · doi:10.1007/s00066-010-2187-1 · Cited by 23 · see citing works
“[15] stated the tolerance dose of the spinal cord to be 50 Gy/25 fractions /5 weeks for minimal injurious dose (TD5/5) and less than 60 Gy/30 fractions/6 weeks for maximal injurious dose (TD50/5) using 1–6 MeV supervoltage therapy.”
Method
A theoretical and computational method for determining optimal treatment schedules in fractionated radiation therapy
Almquist, K. J., & Banks, H. T. (1976) · Mathematical Biosciences · doi:10.1016/0025-5564(76)90034-1 · Cited by 23 · see citing works
Acute and Late Toxicity in Radical Radiotherapy for Bladder Cancer
Majewski, W., & Tarnawski, R. (2009) · Clinical Oncology · doi:10.1016/j.clon.2009.04.008 · Cited by 22 · see citing works
Submandibular Gland Transfer for the Prevention of Postradiation Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-Analysis
Wu, F., Weng, S., Li, C., Sun, J., Li, L., & Gao, Q. (2015) · ORL · doi:10.1159/000371854 · Cited by 22 · see citing works
Second Primary Germ Cell Tumors in Patients with Seminoma of the Testis
Cockburn, A. G., Vugrin, D., Batata, M. A., et al. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)51149-0 · Cited by 21 · see citing works
Irradiation-induced effects on the innervation of rat salivary glands: Changes in enkephalin- and bombesin-like immunoreactivity in ganglionic cells and intraglandular nerve fibers
Franzén, L., Forsgren, S., Gustafsson, H., et al. (1993) · Cell and Tissue Research · doi:10.1007/bf02913737 · Cited by 20 · see citing works
“The decrease in flow rate then continues throughout the treatment period, and if all salivary glands are irradiated to a total dose over 50 Gy, persistent xerostomia may occur (Makkonen et al. 1986a; Makkonen et al. 1986b; Mossman et al. 1982; Rubin and Casarett 1972; Wescott et al. 1981).”
Background
Theoretical Determination of Optimal Treatment Schedules for Radiation Therapy
Hethcote, H. W., & Waltman, P. (1973) · Radiation Research · doi:10.2307/3573799 · Cited by 19 · see citing works
Lower Intestinal Hemorrhage
Ellis, D. J., & Reinus, J. F. (1995) · Critical Care Clinics · doi:10.1016/s0749-0704(18)30072-1 · Cited by 20 · see citing works
Frequent Short-Term Oral Complications of Head and Neck Radiotherapy
Mossman, K. L. (1994) · Ear Nose & Throat Journal · doi:10.1177/014556139407300508 · Cited by 19 · see citing works
Can dose–response models predict reliable normal tissue complication probabilities in radical radiotherapy of urinary bladder cancer? The impact of alternative radiation tolerance models and parameters
Muren, L. P., Jebsen, N. L., Gustafsson, A., et al. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01464-x · Cited by 18 · see citing works
Clinical Trial Design and Scoring of Radionuclide Therapy Endpoints: Normal Organ Toxicity and Tumor Response
Meredith, R. F. (2002) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/10849780252824109 · Cited by 18 · see citing works
Current Status of Conformal Radiotherapy
Dahl, O., Kardamakis, D., Lind, B., et al. (1996) · Acta Oncologica · doi:10.3109/02841869609098520 · Cited by 17 · see citing works
Malignant Brain Tumors in Children
Jacobi, G., & Kornhuber, B. (1987) · Springer eBooks · doi:10.1007/978-3-7091-8876-7_8 · Cited by 17 · see citing works
Time/dose relationships in abdominal irradiation: a definition of principles and experimental evaluation
Hagemann, R. F., & Concannon, J. P. (1975) · British Journal of Radiology · doi:10.1259/0007-1285-48-571-545 · Cited by 16 · see citing works
Variation in radiation sensitivity and repair kinetics in different parts of the spinal cord
Adamus-Górka, M., Brahme, A., Mavroidis, P., et al. (2008) · Acta Oncologica · doi:10.1080/02841860701864668 · Cited by 15 · see citing works
Impact of Endogenous and Exogenous Factors on Radiation Sequelae
Baumann, M. A. (1995) · Medical radiology · doi:10.1007/978-3-642-46794-3_1 · Cited by 15 · see citing works
The diagnostic value of CT for radiotherapy of cerebral tumors
Kretzschmar, K., Aulich, A., Schindler, E., et al. (1978) · Neuroradiology · doi:10.1007/bf00418623 · Cited by 14 · see citing works
Late Effects of Unilateral Radiation on the Mouse Kidney
Jordan, S. W., Yuhas, J. M., & Key, C. R. (1978) · Radiation Research · doi:10.2307/3574791 · Cited by 13 · see citing works
Alternating chemotherapy and radiotherapy combination for bulky stage I and II intermediate and high grade non-Hodgkin lymphoma: an update
Cosset, J., Henry-Amar, M., Vuong, T., et al. (1991) · Radiotherapy and Oncology · doi:10.1016/0167-8140(91)90109-t · Cited by 12 · see citing works
Radiation myelopathy after radioactive iodine therapy for spine metastasis
Murakami, H., Kawahara, N., Yahata, T., et al. (2006) · British Journal of Radiology · doi:10.1259/bjr/16265478 · Cited by 10 · see citing works
Potential for a pluripotent adult stem cell treatment for acute radiation sickness
Rodgerson, D. O. (2012) · World Journal of Experimental Medicine · doi:10.5493/wjem.v2.i3.37 · Cited by 9 · see citing works
Tongue cancer treated with irradiation: Assessment with MR imaging
Sugimura, K., Kuroda, S., Furukawa, T., et al. (1992) · Clinical Radiology · doi:10.1016/s0009-9260(05)80163-1 · Cited by 9 · see citing works
Clinical Implications of Radiobiological Studies on CNS Tolerance
van der Kogel, A. J. (1991) · Glioma · doi:10.1007/978-3-642-84127-9_14 · Cited by 9 · see citing works
Radiotherapy in Childhood: Normal Tissue Injuries and Carcinogenesis
Molls, M., & Stuschke, M. (1991) · Medical radiology · doi:10.1007/978-3-642-83416-5_16 · Cited by 9 · see citing works
Irregular field dose determination with the weighted beam-zone method
Quast, U., & Glaeser, L. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90629-0 · Cited by 8 · see citing works
Simultaneous Bilateral Testicular Tumors, One Side clinically Occult: Detection by Ultrasonography
Sanchez, S., & Mahlin, M. S. (1986) · The Journal of Urology · doi:10.1016/s0022-5347(17)45749-1 · Cited by 8 · see citing works
Urination Frequency and Cystic Pressure Resistance After Fractionated whole or Partial Irradiation of the Rabbit Urinary Bladder
Kohler, M., Eppenberger, H. M., Cordt-Riehle, I., et al. (1992) · Acta Oncologica · doi:10.3109/02841869209083852 · Cited by 7 · see citing works
Postradiation Changes in Tissues
Domachevsky, L., Jacene, H. A., Sakellis, C. G., et al. (2013) · PET Clinics · doi:10.1016/j.cpet.2013.10.005 · Cited by 7 · see citing works
Treatment Indications and Clinical Target Volume
Houtte, P. V., Ball, D., Danhier, S., et al. (1999) · Medical radiology · doi:10.1007/978-3-642-59824-1_20 · Cited by 7 · see citing works
Planejamento tridimensional para radioterapia de tumores de esôfago: comparação de técnicas de tratamento e análise de probabilidade de complicações
Justino, P. B., Carvalho, H. D. A., Ferauche, D. C., et al. (2003) · Radiologia Brasileira · doi:10.1590/s0100-39842003000300007 · Cited by 6 · see citing works
Assessment of the dose distribution of Minibeam radiotherapy for lung tumors in an anthropomorphic phantom: A feasibility study
Zeinali-Rafsanjani, B., Mosleh‐Shirazi, M. A., Haghighatafshar, M., et al. (2017) · Technology and Health Care · doi:10.3233/thc-170818 · Cited by 6 · see citing works
“Tolerance doses of lung, heart and ribs were 65, 70, 65 Gy, respectively [29–31].”
The dose–response relation for rat spinal cord paralysis analyzed in terms of the effective size of the functional subunit
Adamus-Górka, M., Mavroidis, P., Brahme, A., et al. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/22/016 · Cited by 6 · see citing works
Repair of Sublethal and Potentially Lethal Damage in Mouse Kidney Cellsin SituUsing anin VitroColony Method
Guichard, M., Deschavanne, P., & Malaise, E. P. (1982) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008214550111 · Cited by 6 · see citing works
Radiation-induced lung damage: Etiopathogenesis, clinical features, imaging findings and treatment
Vasić, L., & Djurdjevic, P. M. (2012) · Medicinski pregled · doi:10.2298/mpns1208319v · Cited by 5 · see citing works
ABDOMINAL RADIOTHERAPY
Feeney, D. A., & Johnston, G. R. (1982) · Veterinary Radiology · doi:10.1111/j.1740-8261.1982.tb01281.x · Cited by 5 · see citing works
THE PITFALLS AND COMPLICATIONS OF RADIATION THERAPY FOR ESOPHAGEAL CARCINOMA
Moni, J., & Nori, D. (1997) · Chest Surgery Clinics of North America · doi:10.1016/s1052-3359(25)00360-6 · Cited by 5 · see citing works
RADIOTHERAPY OF THE EXPREMITIES
Johnston, G. R., & Feeney, D. A. (1983) · Veterinary Radiology · doi:10.1111/j.1740-8261.1983.tb01553.x · Cited by 5 · see citing works
Toward tailoring radiation protection strategies at an individual level
Hamada, N., Salomaa, S. I., & Dörr, W. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1513178 · Cited by 5 · see citing works
“…Rubin and Casarett proposed a clinically acceptable minimum injurious tolerance dose, defined as a dose that causes severe normal tissue complications in ‘1–5%’ and ‘25–50%’ of patients within 5 years after radiotherapy (abbreviated as TD5/5 and TD50/5, respectively) (Rubin and Casarett 1972).”
Background
Radiation therapy tolerance limits: For one or for all?-Janeway lecture
Peters, L. J. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960601)77:11 · Cited by 66 · see citing works
Peptide receptor radionuclide therapy: a new era of radiation nephropathy
Das, A., Kendi, A. T., & Manohar, S. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaf121 · Cited by 5 · see citing works
Tolerance of Normal Tissue to Therapeutic Radiation
Emami (2013) · Cited by 4 · see citing works
Multivariate non-invasive measurements of skin disorders
Nyström, J. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 4 · see citing works
Radiotoxic model for three-dimensional treatment planning. Part 1: Theoretical basis
Caudry, M., Causse, N., Trouette, R., et al. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90322-m · Cited by 4 · see citing works
A new technique for irradiating thoracic inlet tumors
Stevens, K. R., Fry, R., & Stone, C. (1978) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(78)90203-1 · Cited by 4 · see citing works
Free focus radiography with miniaturized dental x-ray machines: A comparison of “midline” and “lateral” techniques
Jensen, T. W. (1983) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(83)90290-6 · Cited by 4 · see citing works
Radiation Damage to the Kidney
Yaes, R. J. (1992) · Advances in radiation biology · doi:10.1016/b978-0-12-035415-3.50006-8 · Cited by 3 · see citing works
Reproductive Organs
Ladner, H.-A. (1991) · Medical radiology · doi:10.1007/978-3-642-83416-5_15 · Cited by 3 · see citing works
Adverse effect of therapy and late sequelae in survivors
Shirato, H., Sawamura, Y., Tada, M., Brauner, R., Adan, L., Souberbielle, J., Satoh, N., Kashiwamura, M., Sawamura, Y., Tada, M., et al. (1998) · Springer eBooks · doi:10.1007/978-3-7091-6821-9_13 · Cited by 3 · see citing works
Improved dose response modeling for normal tissue damage and therapy optimization.
Adamus-Górka, M. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3 · see citing works
Complications associated with the treatment of small cell lung cancer
Feld, R. D. (1994) · Lung Cancer · doi:10.1016/0169-5002(94)91695-0 · Cited by 3 · see citing works
Influence of dietary protein levels on survival of rats following kidney irradiation
Mahler, P. A., & Yatvin, M. B. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90103-1 · Cited by 3 · see citing works
Bestrahlungsplanung
Sack, H., Quast, U., & Stuschke, M. (1996) · Strahlentherapie · doi:10.1007/978-3-642-79432-2_9 · Cited by 3 · see citing works
Bone
Luz, A., Gössner, W., & Heuck, F. (1991) · Medical radiology · doi:10.1007/978-3-642-83416-5_3 · Cited by 3 · see citing works
The Radiosensitivity of the Infant Brain
Hinkelbein, W., & Wannenmacher, M. F. (1982) · Springer eBooks · doi:10.1007/978-3-642-95413-9_42 · Cited by 3 · see citing works
Radiobiological modeling of radiation-induced acute rectal mucositis: A single-institutional study of cervical carcinoma
Singh, B. B., Singh, G., Oinam, A. S., et al. (2021) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_879_21 · Cited by 2 · see citing works
Dose-Time-Volume Relationships in Normal Tissue Response to Irradiation
Awwad, H. K. (1990) · Springer eBooks · doi:10.1007/978-94-015-7865-3_6 · Cited by 2 · see citing works

Authors: Rubin, P., & Casarett, G.
Affiliations: Strong Memorial Hospital (US)
Corresponding author: Rubin, P.
Venue: Frontiers of radiation therapy and oncology
Publisher: S. Karger AG
Published: 2015-04-15
Pages: 1-16
ISSN: 0071-9676 (ISSN-L)
1662-3789
DOI: 10.1159/000392794
OpenAlex: W2242799666
Cited by: 132
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
FWCI: 11.36
Type: book chapter
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Frontiers of radiation therapy and oncology (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiology practices and education
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advances in Oncology and Radiotherapy
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: radiation-induced pathology, radiation injury, radiotherapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Direction for Clinical Radiation Pathology

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks