The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Essence of Aging
Abstract
The idea that aging is a purposeful, programmed series of events is intuitively appealing based on its many conserved aspects and the demonstrated feasibility of modifying life span by manipulating single genes or pathways. Yet, the case for a nonadaptive basis of aging is strong and now all but generally accepted in the field. Here, we briefly review why the case for programmed aging is weak, with a focus on the lack of possible evolutionary beneficial effects.
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The idea that ageing is a purposeful, programmed series of events that evolved under the direct force of natural selection to cause death has been all but discredited.
“The idea that ageing is a purposeful, programmed series of events that evolved under the direct force of natural selection to cause death has now been all but discredited12.”
From Evidence for a limit to human lifespan (2016) · cites this paper as [12]
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Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764
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Research works printed but not linked: 15
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Cited by
Sorted by citations
Evidence for a limit to human lifespan
Dong, X., Milholland, B., & Vijg, J. (2016) · Nature · doi:10.1038/nature19793 · Cited by 495
Self-citationAging clocks based on accumulating stochastic variation
Meyer, D. H., & Schumacher, B. (2024) · Nature Aging · doi:10.1038/s43587-024-00619-x · Cited by 128
Metadata
- Authors
- Vijg, J., & Kennedy, B. K.
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2015-09-22
- Volume
- 62
- Issue
- 4
- Pages
- 381-385
- ISSN
- 0304-324X
- 1423-0003
- PMC
- PMC4803632
- Cited by
- 33
- References
- 1
- Language
- en
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