The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Genetic and Environmental Factors Underlying Hypospadias
Open accessAbstract
Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in 200-300 boys. It is thought to be due to a combination of genetic and environmental factors. The development of the penis progresses in 2 stages: an initial hormone-independent phase and a secondary hormone-dependent phase. Here, we review the molecular pathways that contribute to each of these stages, drawing on studies from both human and mouse models. Hypospadias can occur when normal development of the phallus is disrupted, and we provide evidence that mutations in genes underlying this developmental process are causative. Finally, we discuss the environmental factors that may contribute to hypospadias and their potential immediate and transgenerational epigenetic impacts.
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Consensus Statement on Management of Intersex Disorders
Lee, P. A., Houk, C. P., Ahmed, S. F., Hughes, I. A., & in collaboration with the participants in the International Consensus Conference on Intersex organized by the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology (2006) · Pediatrics · doi:10.1542/peds.2006-0738 · Cited by 2,324
Physiological role for the cochaperone FKBP52 in androgen receptor signaling
Cheung-Flynn, J., Prapapanich, V., Cox, M. B., Riggs, D. L., Suarez-Quian, C., & Smith, D. F. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0071 · Cited by 212
Kim, K., Liu, W., Cunha, G. R., Russell, D. W., Huang, H., Shapiro, E., & Baskin, L. S. (2002) · Cell and Tissue Research · doi:10.1007/s004410100464 · Cited by 118
Rubtsov, P., Karmanov, M., Sverdlova, P., Spirin, P., & Tiulpakov, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1118 · Cited by 82
Cited by
Hypospadias, all there is to know
van der Horst, H. J. R., & de Wall, L. L. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2864-5 · Cited by 308
Metadata
- Authors
- Bouty, A., Ayers, K. L., Pask, A., Heloury, Y., & Sinclair, A. H.
- Venue
- Sexual Development
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 9
- Issue
- 5
- Pages
- 239-259
- ISSN
- 1661-5425 (ISSN-L)
- 1661-5433
- OpenAlex
- W2185902525
- Cited by
- 243
- References
- 4
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bouty, A., Ayers, K. L., Pask, A., Heloury, Y., & Sinclair, A. H. (2015). The Genetic and Environmental Factors Underlying Hypospadias. Sexual Development. https://doi.org/10.1159/000441988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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