Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats
Open accessAbstract
Lesion of posterodorsal amygdala (PDA) has been known to produce hyperphagia and obesity in animal models. However, the influence of gender on food intake (FI), body weight (BW) and immunological parameters following PDA lesion is not yet known. The present work was carried out to study the effect of gender on the regulation of FI, BW and immunological parameters following lesions of PDA in albino Wistar rats. Twenty-four albino Wistar rats were divided equally into 2 groups - PDA group and control group - with 6 male and 6 female rats in each. In the experimental group, bilateral electrolytic lesion of the respective nuclei was performed by stereotaxy and post-lesion parameters were recorded. In the control group, sham lesion was made. Male-female difference in each parameter was determined. Following PDA lesion, FI increased significantly in both male (p < 0.001) and female rats (p < 0.01) but the percentage increase in FI was significantly more in female rats (p < 0.001). BW also increased in both the sexes but the increase in BW was significant only in male rats (p < 0.05). Both male and female rats showed increase in the concentration of cluster of differentiation 4 (CD4), but the significant increase in CD4 concentration (p < 0.01) was seen only in male rats. CD8 concentration increased significantly in male rats (p < 0.05). The liver weight-BW ratio was significantly greater in female rats (p < 0.001) following PDA lesions. Lesion of PDA results in accentuation of FI and BW gain and activation of immunity. There is a gender difference in the inhibitory control of PDA on FI, BW and immunity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Striking sex differences have been observed in eating behaviours and food cravings, resulting in an increased risk for obesity.
“Furthermore, striking sex differences have been observed in eating behaviours and food cravings, resulting in an increased risk for obesity 30, 31, 32.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem
König, J. F. R., & Klippel, R. (1986) · Medical Entomology and Zoology · Cited by 4,134 · see citing works
Isaacson, R. L. (1974) · Medical Entomology and Zoology · Cited by 743 · see citing works
Causes of obesity: Looking beyond the hypothalamus
Peters, A., Pellerin, L., DALLMAN, M., Oltmanns, K. M., Schweiger, U., Jan Born, A., & Fehm, H. L. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.004 · Cited by 92 · see citing works
Amygdala-lesion obesity: what is the role of the various amygdaloid nuclei?
Rollins, B. L., & King, B. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1348 · Cited by 77 · see citing works
King, B. M. (2006) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00199.2006 · Cited by 59 · see citing works
Manteuffel, G. (2002) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-45-575-2002 · Cited by 58 · see citing works
King, B. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02146-9 · Cited by 31 · see citing works
Jacobson, J. D., Ansari, M. A., Mansfield, M. E., et al. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70338-6 · Cited by 29 · see citing works
Posterodorsal Amygdaloid Lesions in Rats: Long-Term Effects on Body Weight
King, B. M., Cook, J. T., Rossiter, K. N., et al. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00318-6 · Cited by 28 · see citing works
Excessive weight gain in rats over extended kindling of the basolateral amygdala
Löscher, W., Brandt, C., & Ebert, U. (2003) · Neuroreport · doi:10.1097/00001756-200310060-00014 · Cited by 26 · see citing works
Peripheral Blood Natural Killer Cell Cytotoxicity after Damage to the Limbic System in the Rat
Jurkowski, M. K., Trojniar, W., Borman, A., Ciepielewski, Z. M., Siemion, D., & Tokarski, J. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2000.0602 · Cited by 22 · see citing works
Babu, M. S., Bobby, Z., & Habeebullah, S. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.04.018 · Cited by 16 · see citing works
Role of ventromedial hypothalamus on energy homeostasis in albino rats: effect of gender.
Dev, S., Pal, P., Pal, G. K., et al. (2013) · PubMed · Cited by 8 · see citing works
Self-citationEffect of dopamine injection into caudate nucleus on immune responsiveness in rats: a pilot study
Nanda, N., Pal, G. K., & Koner, B. C. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.07.013 · Cited by 7 · see citing works
Self-citationPal, G. K., Pal, P., Nanda, N., et al. (2007) · Annals of Neurosciences · doi:10.5214/172 · Cited by 4 · see citing works
Self-citationLalitha, V., Pal, G., Pal, P., et al. (2014) · International Journal of Clinical and Experimental Physiology · doi:10.4103/2348-8093.129733 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [11]Parija SC Immune response in Text Book of Microbiology & Immunology 2009 ed 1 Haryana Elsevier 139 148
Cited by
Sorted by citations
Osadchiy, V., Mayer, E. A., Bhatt, R., Labus, J. S., Gao, L., Kilpatrick, L. A., Liu, C., Tillisch, K., Naliboff, B., Chang, L., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.362 · Cited by 44 · see citing works
Gupta, A., Mayer, E. A., Labus, J. S., Bhatt, R. R., Ju, T., Love, A., Bal, A., Tillisch, K., Naliboff, B., Sanmiguel, C. P., et al. (2018) · Obesity · doi:10.1002/oby.22060 · Cited by 29 · see citing works
- Authors
- Lalitha, V., Pal, G. K., Pal, P., Parija, S. C., & Murugaiyan, S. B.
- Affiliations
- Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
- Corresponding author
- Pal, Gopal Krushna
- Venue
- Annals of Neurosciences
- Publisher
- SAGE Publications
- Published
- 2016
- Volume
- 23
- Issue
- 1
- Pages
- 6-12
- ISSN
- 0972-7531 (ISSN-L)
- 0976-3260
- PMC
- PMC4934414
- OpenAlex
- W2339575751
- Cited by
- 11
- References
- 16
- Citations by year
- 2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurosciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- dietary intake, obesity, body weight, sex differences, hyperphagia, electrolytic lesions, CD4, CD8, immune activation, liver weight, Wistar rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
