Effects of Exercise on Functional Performance and Fall Rate in Subjects with Mild or Advanced Alzheimer’s Disease: Secondary Analyses of a Randomized Controlled Study
Abstract
BACKGROUND: Exercise improves functional performance in subjects with dementia. However, whether the benefits of exercise are evident in all stages of dementia remains uncertain. This study examines how people in different stages of Alzheimer's disease (AD) benefit from exercise intervention in their physical functioning and risk of falling. METHODS: The present study is a subanalysis of a randomized controlled trial examining the effects of exercise intervention (twice a week for 12 months) in AD patients (n = 194). We studied the effects separately in participants with mild dementia and in participants with advanced dementia. RESULTS: In subjects with mild dementia, the deterioration in physical functioning was slower in the intervention group than in the controls. Changes in Functional Independence Measure at 12 months were -2.7 (95% CI -0.5 to -4.9) in the intervention group and -10.1 (95% CI -7.0 to -13.3) in the control group (p < 0.001). The exercise intervention proved effective in preventing falls among patients with advanced AD, with an incidence rate ratio of 0.47 (95% CI 0.37-0.60; p < 0.001). CONCLUSIONS: Regular exercise may slow the rate of functional deterioration in mild AD and reduce falls in patients suffering from advanced AD.
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Physical exercises improve cognition and quality of life, and home-based exercises improve balance and fear of falling and executive functions.
“Physical exercises are reported to improve cognition and quality of life, and home-based exercises seemed to improve balance and fear of falling and executive functions [190,191,192].”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [192]
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Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies
Buccellato, F. R., D’Anca, M., Tartaglia, G. M., Del Fabbro, M., Scarpini, E., & Galimberti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813900 · Cited by 94 · see citing works
- Authors
- Öhman, H., Savikko, N., Strandberg, T., Kautiainen, H., Raivio, M., Laakkonen, M.-L., Tilvis, R., & Pitkälä, K. H.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 41
- Issue
- 3-4
- Pages
- 233-241
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2345581789
- Cited by
- 49
- References
- 34
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 2
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- exercise intervention, Alzheimer's disease, mild dementia, advanced dementia, functional performance, physical function, fall risk, fall prevention, Functional Independence Measure, functional decline, dementia stages
- MeSH terms
- Accidental Falls, Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Exercise Therapy, Female, Humans, Male, Research Design, Treatment Outcome
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