Chronobiology of Aging: A Mini-Review
Abstract
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions. Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans. Caloric restriction, which is consistently and reproducibly associated with prolonging life in different animal models, is associated with an increased circadian amplitude. These results indicate the critical importance of chronobiology in dealing with problems of aging, from the circadian clock machinery orchestrating metabolism to the development of geroprotectors. The quantitative estimation of circadian rhythm characteristics interpreted in the light of time-specified reference values helps (1) to distinguish effects of natural healthy aging from those associated with disease and predisease; (2) to detect alterations in rhythm characteristics as markers of increased risk before there is overt disease; and (3) to individually optimize by timing prophylactic and/or therapeutic interventions aimed at restoring a disturbed circadian system and/or enhancing a healthy life span. Mapping changes in amplitude and/or acrophase that may overshadow any change in average value also avoids drawing spurious conclusions resulting from data collected at a fixed clock hour. Timely risk detection combined with treatment optimization by timing (chronotherapy) is the goal of several ongoing comprehensive community-based studies focusing on the well-being of the elderly, so that longevity is not achieved at the cost of a reduced quality of life.
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In older adults, rhythms often return to being substantially earlier, and this shift may be accompanied by a weakening of circadian rhythms.
“In older adults, rhythms often return to being substantially earlier, and this shift may be accompanied by a weakening of circadian rhythms11,12.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [12]
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- Authors
- Cornelissen, G., & Otsuka, K.
- Affiliations
- Tokyo Women's Medical University (JP)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2016-10-22
- Volume
- 63
- Issue
- 2
- Pages
- 118-128
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2535649952
- Cited by
- 96
- References
- 38
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 15 · 2023: 9 · 2022: 5 · 2021: 19 · 2020: 13 · 2019: 13 · 2018: 6 · 2017: 5
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- aging, circadian rhythm, circadian amplitude, suprachiasmatic nucleus, clock genes, caloric restriction, healthspan, geroprotectors, chronotherapy, quality of life in old age
- MeSH terms
- Aging, Animals, Chronobiology Phenomena, Circadian Rhythm, Humans, Longevity, Suprachiasmatic Nucleus, Signal Transduction, Caloric Restriction, Metabolic Networks and Pathways, Circadian Clocks
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