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Cited by 62Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsEnhanced Recovery After Surgery

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Mori, Hideki, Suzuki, Hidekazu, Matsuzaki, Juntaro, Taniguchi, Kanami, Shimizu, Toshiyuki, Yamane, Tsuyoshi, Masaoka, Tatsuhiro, Kanai, Takanori·2017·Digestion
DOI 10.1159/000452359
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Abstract

Background and Aim: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The 13 C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of 13 C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of 13 C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of 13 C-acetate breath test. Methods: Fifty-two healthy individuals and 126 patients with patients with FD were enrolled. Gastric emptying was evaluated by the 13 C-acetate breath test. The cut-off points of T max for the diagnosis of delayed gastric emptying were determined on the basis of results from healthy individuals making a distinction of genders. Gastroesophageal reflux symptoms, dyspeptic symptoms, scores of anxiety and depression, age, body mass index (BMI), smoking and alcohol consumption were compared between the delayed gastric emptying group and the non-delayed gastric emptying group. Results: Since gastric emptying was delayed in healthy women compared with that in healthy men (T max, 53.6 ± 19.3 vs. 42.7 ± 16.9 min, p = 0.04), we set the cut-off points of T max at 60 min in men and at 75 min in women. In patients with FD, the prevalence of delayed gastric emptying was not different between men and women with the modified standard values of 13 C-acetate breath test. (31.0 vs. 27.4%, p = 0.68). BMI was lower in the delayed gastric emptying group than in the non-delayed group among the male patients. Reflux symptoms were more severe in delayed gastric emptying group than in the non-delayed group among the female patients. Conclusion: The standard values of 13 C-acetate breath test should be modified bearing the gender difference in mind. It provides us more appropriate information to understand the mechanisms of FD.

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Crossref · 10.1159/000452359

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29 of 29 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. 10.1111/j.1572-0241.2003.07389.x · DOI · Paper page

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Metadata

Authors
Mori, H., Suzuki, H., Matsuzaki, J., Taniguchi, K., Shimizu, T., Yamane, T., Masaoka, T., & Kanai, T.
Affiliations
Keio University (JP)
ORCID
Venue
Digestion
Publisher
S. Karger AG
Published
2017
Volume
95
Issue
1
Pages
72-78
ISSN
  • 0012-2823 (ISSN-L)
  • 1421-9867
DOI
10.1159/000452359
OpenAlex
W2568412429
Cited by
62
References
29
Citations by year
2026: 6 · 2025: 8 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 6
FWCI
5.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestion (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Takeda Pharmaceutical Company
  • Eisai
  • Astellas Pharma
  • Otsuka Pharmaceutical
  • Japan Society for the Promotion of Science (16H05291)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords
functional dyspepsia, gastric emptying, delayed gastric emptying, 13C-acetate breath test, sex differences, reference values, cut-off values, Tmax, gastroesophageal reflux, prevalence, body mass index
MeSH terms
Acetates, Adult, Breath Tests, Dyspepsia, Female, Gastric Emptying, Gastroesophageal Reflux, Humans, Male, Middle Aged, Surveys and Questionnaires, Reference Standards, Sex Factors, Body Mass Index, Case-Control Studies, Healthy Volunteers

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.