Pharmacokinetics of Haloperidol Decanoate
Abstract
Plasma haloperidol levels were assayed in 181 chronic schizophrenic inpatients, who were monthly injected intramuscularly with haloperidol decanoate. Steady state levels are reached after the third monthly injection and then remain constant, being associated with a remarkably stable control of the psychotic condition. Between two subsequent injections the haloperidol levels decrease gradually by about half their initial value. The haloperidol plasma levels strongly correlate with the injected doses of the decanoate form. For a single dose of 100 mg haloperidol decanoate monthly the minimal steady state value is about 4 ng/ml
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Peak plasma concentrations of haloperidol decanoate are apparent between 3 and 9 days, with an elimination half-life of approximately 3 weeks.
“Peak plasma concentrations are apparent between 3 and 9 days, with an elimination half-life of approximately 3 weeks [39, 54].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [39]
Steady-state levels of haloperidol decanoate are achieved after the third injection, or after 3 months, a period approximately four to five times the apparent half-life.
“Steady-state levels are achieved after the third injection, or after 3 months, which is a period approximately four to five times the apparent half-life [39].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [39]
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- Authors
- Reyntjens, A. J. M., Heykants, J. J. P., Woestenborghs, R. J. H., Gelders, Y. G., & Aerts, T. J. L.
- Affiliations
- Janssen (Belgium) (BE)
- Venue
- International Pharmacopsychiatry
- Publisher
- S. Karger AG
- Published
- 2017-08-11
- Volume
- 17
- Issue
- 4
- Pages
- 238-246
- ISSN
- 0020-8272 (ISSN-L)
- 2504-2580
- OpenAlex
- W193920943
- Cited by
- 46
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2014: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
- Keywords
- haloperidol decanoate, pharmacokinetics, plasma drug concentration, chronic schizophrenia, intramuscular injection, dose-response relationship, antipsychotic drugs
- MeSH terms
- Chronic Disease, Dose-Response Relationship, Drug, Female, Haloperidol, Humans, Kinetics, Male, Schizophrenia
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