Cited by 46Schizophrenia research and treatmentPharmacogenetics and Drug MetabolismHistorical Psychiatry and Medical Practices

Pharmacokinetics of Haloperidol Decanoate

Reyntjens, A.J.M., Heykants, J.J.P, Woestenborghs, R.J.H., Gelders, Y.G., Aerts, T.J.L.·2017·International Pharmacopsychiatry

Abstract

Plasma haloperidol levels were assayed in 181 chronic schizophrenic inpatients, who were monthly injected intramuscularly with haloperidol decanoate. Steady state levels are reached after the third monthly injection and then remain constant, being associated with a remarkably stable control of the psychotic condition. Between two subsequent injections the haloperidol levels decrease gradually by about half their initial value. The haloperidol plasma levels strongly correlate with the injected doses of the decanoate form. For a single dose of 100 mg haloperidol decanoate monthly the minimal steady state value is about 4 ng/ml

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Crossref · 10.1159/000468580

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Authors
Reyntjens, A. J. M., Heykants, J. J. P., Woestenborghs, R. J. H., Gelders, Y. G., & Aerts, T. J. L.
Affiliations
Janssen (Belgium) (BE)
Venue
International Pharmacopsychiatry
Publisher
S. Karger AG
Published
2017-08-11
Volume
17
Issue
4
Pages
238-246
ISSN
  • 0020-8272 (ISSN-L)
  • 2504-2580
OpenAlex
W193920943
Cited by
46
References
0
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2014: 1
FWCI
0.22
Type
journal article
Language
en
Open access
closed
Locations
  • International Pharmacopsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
Keywords
haloperidol decanoate, pharmacokinetics, plasma drug concentration, chronic schizophrenia, intramuscular injection, dose-response relationship, antipsychotic drugs
MeSH terms
Chronic Disease, Dose-Response Relationship, Drug, Female, Haloperidol, Humans, Kinetics, Male, Schizophrenia

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