Release and absorption rate aspects of intramuscularly injected pharmaceuticals
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Absorption from the injection site can be influenced by properties of the drug, including water solubility and the delivery vehicle, and patient factors such as body weight, subcutaneous fat, and vascularity of the site of injection.
“Absorption from the injection site can be influenced by properties of the drug, including water solubility and the delivery vehicle, and patient factors such as body weight, subcutaneous fat, and vascularity of the site of injection [25, 34, 35].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [35]
Cites
Human stratum corneum lipids: characterization and regional variations
Lampe, M. A., Burlingame, A. L., Whitney, J., Williams, M. L., Brown, B. E., Roitman, E., & Elias, P. M. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38005-6 · Cited by 692 · see citing works
Sustained-and Controlled-Release Drug-Delivery Systems
Robinson, J., & Jantzen, G. (2002) · Drugs and the pharmaceutical sciences · doi:10.1201/9780824744694.ch15 · Cited by 384 · see citing works
Human epidermal lipids: characterization and modulations during differentiation
Lampe, M. A., Williams, M. L. K., & Elias, P. M. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38006-8 · Cited by 355 · see citing works
Clinical Pharmacokinetics of Dapsone
Zuidema, J., Hilbers-Modderman, E. S. M., & Merkus, F. W. H. M. (1986) · Clinical Pharmacokinetics · doi:10.2165/00003088-198611040-00003 · Cited by 246 · see citing works
Self-citationControlled Release Delivery Systems
Lonsdale, H. K. (1983) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)81365-4 · Cited by 240 · see citing works
DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES
de Boer, A. G., de Leede, L. G. J., & Breimer, D. D. (1984) · British Journal of Anaesthesia · doi:10.1093/bja/56.1.69 · Cited by 172 · see citing works
Intramuscular or Intralipomatous Injections?
Cockshott, W. P., Thompson, G. T., Howlett, L. J., & Seeley, E. T. (1982) · New England Journal of Medicine · doi:10.1056/nejm198208053070607 · Cited by 146 · see citing works
Biopharmaceutical Considerations in Subcutaneous and Intramuscular Drug Administration
Ballard, B. E. (1968) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600570301 · Cited by 136 · see citing works
Blood flow in muscle groups and drug absorption
Evans, E. F., Proctor, J. D., Fratkin, M. J., Velandia, J., & Wasserman, A. J. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197517144 · Cited by 117 · see citing works
Absolute Bioavailability of Oral and Intramuscular Diazepam
Divoll, M., Greenblatt, D. J., Ochs, H. R., & Shader, R. I. (1983) · Anesthesia & Analgesia · doi:10.1213/00000539-198301000-00001 · Cited by 101 · see citing works
Schürmann, W., & Turner, P. (1978) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1978.tb13185.x · Cited by 83 · see citing works
BUCCAL MORPHINE—A NEW ROUTE FOR ANALGESIA?
Bell, M. D. D., Mishra, P., WELDON, B. D., Murray, G. R., Calvey, T. N., & Williams, N. E. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91965-8 · Cited by 83 · see citing works
Fatal Rabies Encephalitis despite Appropriate Post-Exposure Prophylaxis
Shill, M., Baynes, R. D., & Miller, S. D. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705143162006 · Cited by 77 · see citing works
Plasma nitroglycerin levels after sublingual, oral and topical administration.
Blumenthal, H. P., Fung, H., McNiff, E. F., & Yap, S. K. (1977) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1977.tb00703.x · Cited by 70 · see citing works
The lipid composition of porcine epidermis and oral epithelium
Squier, C. A., Cox, P., Wertz, P. W., & Downing, D. T. (1986) · Archives of Oral Biology · doi:10.1016/0003-9969(86)90006-3 · Cited by 57 · see citing works
Bioavailability of Propranolol After Oral, Sublingual, and Intranasal Administration
Duchateau, G. S. M. J. E., Zuidema, J., & Merkus, F. W. H. M. (1986) · Pharmaceutical Research · doi:10.1023/a:1016345504153 · Cited by 51 · see citing works
Self-citationPharmacokinetics of Haloperidol Decanoate
Reyntjens, A. J. M., Heykants, J. J. P., Woestenborghs, R. J. H., Gelders, Y. G., & Aerts, T. J. L. (2017) · International Pharmacopsychiatry · doi:10.1159/000468580 · Cited by 46 · see citing works
Drug recovery following buccal absorption of propranolol.
Henry, J., Ohashi, K., Wadsworth, J., & Turner, P. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb00502.x · Cited by 41 · see citing works
Sex differences in the intramuscular absorption and bioavailability of cephradine
Vukovich, R. A., BRANNICK, L. J., Sugerman, A., & NEISS, E. S. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975182215 · Cited by 40 · see citing works
Hirano, K., Ichihashi, T., & Yamada, H. (1981) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.29.817 · Cited by 36 · see citing works
Nasal absorption of alprenolol and metoprolol
Duchateau, G. S. M. J. E., Zuidema, J., Albers, W. M., & Merkus, F. W. H. M. (1986) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(86)90019-0 · Cited by 33 · see citing works
Self-citationIntramuscular Absorption of Drugs from Oily Solutions in the Rat
Tanaka, T., Kobayashi, H., Okumura, K., Muranishi, S., & Sezaki, H. (1974) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.22.1275 · Cited by 31 · see citing works
The Lipoidal Permeability Barriers of the Skin and Alimentary Tract
Curatolo, W. J. (1987) · Pharmaceutical Research · doi:10.1023/a:1016432817415 · Cited by 29 · see citing works
Blood Lidocaine Levels and Kinetics following High-Dose Intramuscular Administration
Zener, J. C., Kerber, R. E., Spivack, A. P., & Harrison, D. C. (1973) · Circulation · doi:10.1161/01.cir.47.5.984 · Cited by 27 · see citing works
PLASMA-DIAZEPAM LEVELS FOLLOWING INTRAMUSCULAR INJECTION BY NURSES AND DOCTORS
Dundee, J. W., Gamble, J. A. S., & ASSAF, R. A. E. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90130-5 · Cited by 27 · see citing works
Absorption kinetics of sublingually administered propranolol.
Kates, R. E. (1977) · PubMed · Cited by 22 · see citing works
Ober, S. S., Vincent, H. C., Simon, D. E., & Frederick, K. J. (1958) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030470915 · Cited by 22 · see citing works
Al-Hindawi, M. K., James, K., & Nicholls, P. J. (1987) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1987.tb06951.x · Cited by 22 · see citing works
The in vivo release of cortisone esters from liposomes and the intramuscular clearance of liposomes
Arrowsmith, M., Hadgraft, J., & Kellaway, I. W. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90181-9 · Cited by 21 · see citing works
The buccal absorption of some -adrenoceptor blocking drugs.
Dc, H. (1973) · PubMed · Cited by 18 · see citing works
Sex differences in the absorption of dapsone after intramuscular injection.
Modderman, E. S. M., Merkus, F. W. H. M., Zuidema, J., Hilbers, H. W., & DIEPEN, T. W. V. (1983) · PubMed · Cited by 16 · see citing works
Self-citationDavis, S. S., Mills, S., & Tomlinson, E. (1987) · Journal of Controlled Release · doi:10.1016/0168-3659(87)90021-6 · Cited by 15 · see citing works
Nifedipine serum concentrations following sublingual and oral doses.
Brown, G., Fraser, D. G., Castile, J. A., Gaudreault, P., Platt, D. R., & Friedman, P. A. (1986) · PubMed · Cited by 12 · see citing works
Castegnaro, E., & Sala, G. (1971) · PubMed · Cited by 8 · see citing works
Effect of Some Non-ionic Surfactants on the Absorption of Enduracidin from the Muscles
Matsuzawa, T., Fujisawa, H., Aoki, K., & Mima, H. (1969) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.17.999 · Cited by 7 · see citing works
Kobayashi, H., Nishimura, T., Okumura, K., Muranishi, S., & Sezaki, H. (1974) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600630419 · Cited by 6 · see citing works
Dapsone levels after oral therapy and weekly oily injections in Ethiopian leprosy patients.
Modderman, E. S. M., Merkus, F. W. H. M., Zuidema, J., Hilbers, H. W., & DIEPEN, T. W. V. (1983) · PubMed · Cited by 5 · see citing works
Self-citationInjections into Fat Instead of Muscle
(1982) · New England Journal of Medicine · doi:10.1056/nejm198212163072515 · Cited by 5 · see citing works
Effect of a Surfactant on Absorption of AM Antibiotic from Non-Aqueous Parenteral Suspensions
Timmins, P., Cosgrove, R. F., & Delarqy, A. M. (1986) · Drug Development and Industrial Pharmacy · doi:10.3109/03639048609048040 · Cited by 4 · see citing works
Sustained release properties of an intra-adiposely administered dapsone depot injection.
Pieters, F. A. J. M., Zuidema, J., & Merkus, F. W. H. M. (1986) · PubMed · Cited by 4 · see citing works
Self-citationIntra-adipose administration of monoacetyldapsone to healthy volunteers.
Pieters, F. A. J. M., & Zuidema, J. (1986) · PubMed · Cited by 4 · see citing works
Self-citationPieters, F. A. J. M., Woonink, F., & Zuidema, J. (1988) · PubMed · Cited by 3 · see citing works
Self-citationPhillips, M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212163072514 · Cited by 3 · see citing works
Flagged first, then by citations
3 of the 47 references couldn’t be matched to a known paper.
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Nanosuspensions in drug delivery
Rabinow, B. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1494 · Cited by 1,529 · see citing works
“Because drug dissolution is often the rate-limiting step in systemic drug uptake from a depo”
BackgroundWong, J., Brugger, A. M., Khare, A. R., Chaubal, M. V., Papadopoulos, P., Rabinow, B. E., Kipp, J., & Ning, J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.008 · Cited by 251 · see citing works
“For other parenteral routes of suspension injections like intramuscular (IM), the absorption of drug may take weeks to months [8].”
BackgroundCorrell, C. U., Kim, E., Sliwa, J. K., Hamm, W., Gopal, S., Mathews, M., Venkatasubramanian, R., & Saklad, S. R. (2021) · CNS Drugs · doi:10.1007/s40263-020-00779-5 · Cited by 205 · see citing works
Darville, N., van Heerden, M., Vynckier, A., Meulder, M. D., Sterkens, P., Annaert, P., & den Mooter, G. V. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24014 · Cited by 120 · see citing works
Titulaer, H. A. C., Zuidema, J., Kager, P. A., Wetsteyn, J. C. F. M., Lugt, C. B., & Merkus, F. W. H. M. (1990) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1990.tb07030.x · Cited by 116 · see citing works
Self-citationRelease and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II)
Zuidema, J., Kadir, F., Titulaer, H. A. C., & Oussoren, C. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90103-1 · Cited by 115 · see citing works
Self-citationMinto, C. F., Howe, C., Wishart, S. M., Conway, A. J., & Handelsman, D. J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36598-x · Cited by 83 · see citing works
Sjöström, B., Bergenståhl, B., & Kronberg, B. (1993) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600820608 · Cited by 72 · see citing works
Iyer, S. S., Barr, W. H., & Karnes, H. T. (2006) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.493 · Cited by 73 · see citing works
“[45] reported that the subcutaneous adipose layer has important retarding effects on the absorption of drugs administered as an oily suspension or liposomes.”
BackgroundDarville, N., van Heerden, M., Mariën, D., Meulder, M. D., Rossenu, S., Vermeulen, A., Vynckier, A., Jonghe, S. D., Sterkens, P., Annaert, P., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.041 · Cited by 72 · see citing works
Larsen, S. W., & Larsen, C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9153-9 · Cited by 73 · see citing works
“injection technique (33), and the interfacial tension of the oil (26).”
BackgroundChu, D., Fu, X., Liu, W., Liu, K., & Li, Y. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.06.032 · Cited by 72 · see citing works
Pharmacokinetics of follicle-stimulating hormone: clinical significance
Wallach, E. E., Ben‐Rafael, Z., Levy, T., & Schoemaker, J. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57467-6 · Cited by 71 · see citing works
Mannaerts, B. M. J. L., Shoham, Z., Schoot, D., Bouchard, P., Harlin, J., Fauser, B. C. J. M., Jacobs, H. S., Rombout, F., & Bennink, H. J. T. C. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55624-6 · Cited by 71 · see citing works
Sustained release veterinary parenteral products
Medlicott, N. J., Waldron, N. A., & Foster, T. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.005 · Cited by 70 · see citing works
Mannaerts, B. M. J. L., Shoham, Z., Schoot, D., Bouchard, P., Harlin, J., Fauser, B. C. J. M., Jacobs, H. S., Rombout, F., & Bennink, H. J. T. C. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00519-0 · Cited by 65 · see citing works
“After intramuscular injection, the release rate of gonadotropins may depend on the formulation, injection depth, site, and volume (14).”
BackgroundLipid based intramuscular long-acting injectables: Current state of the art
Wilkinson, J. M., Ajulo, D., Tamburrini, V., Gall, G. L., Kimpe, K., Holm, R., Belton, P., & Qi, S. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106253 · Cited by 55 · see citing works
A Guide to Pharmaceutical Particulate Science
Hickey, A. J., Crowder, T. M., Louey, M. D., & Orr, N. (2003) · CRC Press eBooks · doi:10.1201/9780203009673 · Cited by 51 · see citing works
Sustained-Release Delivery of Octreotide from Biodegradable Polymeric Microspheres
Rhee, Y.-S., Sohn, M., Woo, B. H., Thanoo, B. C., DeLuca, P. P., & Mansour, H. M. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9693-z · Cited by 48 · see citing works
Comparative absorption kinetics of intramuscular midazolam and diazepam
Hung, O. R., Dyck, J. B., Varvel, J. R., Shafer, S. L., & Stanski, D. R. (1996) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03018105 · Cited by 41 · see citing works
Wassenaar, J. W., Boss, G. R., & Christman, K. L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.06.033 · Cited by 38 · see citing works
“Many factors can affect IM absorption [23,24], but binding to the ECM is rarely considered.”
The role of procaine in adverse reactions to procaine penicillin in horses
CHAPMAN, C., Courage, P., NIELSEN, I., SITARAM, B., & Huntington, P. J. (1992) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1992.tb07480.x · Cited by 38 · see citing works
Hollow microneedles as a flexible dosing control solution for transdermal drug delivery
Kim, J., Jeong, J., Jo, J. K., & So, H. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101754 · Cited by 35 · see citing works
“Delivery depth is a critical parameter affecting the absorption rate and must be carefully considered for effective systemic drug delivery [179].”
Long acting systemic HIV pre-exposure prophylaxis: an examination of the field
Lykins, W. R., Luecke, E. H., Johengen, D., van der Straten, A., & Desai, T. A. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-017-0391-6 · Cited by 33 · see citing works
The contribution of the in-vivo fate of an oil depot to drug absorption
Kalicharan, R. W., Oussoren, C., Schot, P., de Rijk, E., & Vromans, H. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.055 · Cited by 32 · see citing works
“Several body parameters have been suggested to be relevant during drug absorption (Prettyman, 2005; Zuidema et al., 1994, 1988): type of tissue, blood and lymph fl ow in tissues, physical activity of the tissue and the local activation of the immune system.”
Nguyen, V. T., Darville, N., & Vermeulen, A. (2022) · The AAPS Journal · doi:10.1208/s12248-022-00771-5 · Cited by 33 · see citing works
“The available volume of interstitial muscle fluid, injected formulation vehicle, and edema all allow for the dissolution of individual drug particles in the early timepoint post-injection (91).”
BackgroundPharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats
Hazra, A., Pyszczynski, N. A., DuBois, D. C., Almon, R. R., & Jusko, W. J. (2007) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.551 · Cited by 31 · see citing works
“On the other hand, the slower absorption pathway may be due to the passage of MPL (hydrolysed by enzymes in the muscle) through the transcellular pathway [10,32].”
BackgroundEvaluating parameters affecting drug fate at the intramuscular injection site
McCartan, A. J. S., Curran, D. W., & Mrsny, R. J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.023 · Cited by 28 · see citing works
Liu, J., Xu, Z., Wu, D., Leithead, A., Johnson, A. R., Zhang, Y., Nie, H., Wagner, A., & Barrett, S. E. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113793 · Cited by 27 · see citing works
Fundamental understanding of drug absorption from a parenteral oil depot
Kalicharan, R. W., Schot, P., & Vromans, H. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.12.011 · Cited by 25 · see citing works
Larsen, S. W., Rinvar, E., Svendsen, O., Lykkesfeldt, J., Friis, G. J., & Larsen, C. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00860-2 · Cited by 22 · see citing works
Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development
Siemons, M., Schroyen, B., Darville, N., & Goyal, N. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00864-9 · Cited by 21 · see citing works
“These involve elements that are related to the physico-chemistry of the drug itself, the combined formulation properties, and the physiology at the site of administration (17, 22, 23).”
BackgroundUnderstanding the effect of counterpressure buildup during syringe injections
Shahriar, M. A., Rewanwar, A., Rohilla, P., & Marston, J. O. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120530 · Cited by 20 · see citing works
Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots
Probst, M., Kühn, J., Scheuch, E., Seidlitz, A., Hadlich, S., Evert, K., Oswald, S., Siegmund, W., & Weitschies, W. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.029 · Cited by 19 · see citing works
Shojaee, S., Asare‐Addo, K., Kaialy, W., Nokhodchi, A., & Cumming, I. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-0013-7 · Cited by 15 · see citing works
Pharmacokinetic and Pharmacodynamic Aspects of Artelinic Acid in Rodents
Titulaer, H. A. C., Eling, W. M. C., & Zuidema, J. (1993) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1993.tb05695.x · Cited by 15 · see citing works
Self-citationNon-aqueous Solutions and Suspensions as Sustained-Release Injectable Formulations
Murdan, S., & Florence, A. T. (2000) · CRC Press eBooks · doi:10.1201/b14421-6 · Cited by 15 · see citing works
Kadir, F., Eling, W. M. C., Crommelin, D. J. A., & Zuidema, J. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90146-5 · Cited by 15 · see citing works
Self-citationKadir, F., Zuidema, J., Pijpers, A., Vulto, A. G., & Verheijden, J. H. M. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90266-7 · Cited by 15 · see citing works
Self-citationIgnacio, R. B., Wohl, D. A., Arends, R., Reddy, V. P., Mu, Y., Javan, A. C., Hughes, M. D., Eron, J. J., Currier, J. S., Smith, D. M., et al. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2706 · Cited by 14 · see citing works
“Compared with gluteal sites, administration of small molecules in the thigh or deltoid has increased rate and decreased variability of absorption.(18) To our knowledge, no studies of anti- SARS- CoV- 2 mAbs have compared pharmacokinetics (PKs) of i.”
InfluentialKadir, F., Zuidema, J., Pijpers, A., Meléndez-Arce, R., Vulto, A. G., & Verheijden, J. H. M. (1990) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.1990.tb00788.x · Cited by 13 · see citing works
Self-citationZhao, Y., Liu, J., Sun, X., Zhang, Z., & Gong, T. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639040903520975 · Cited by 12 · see citing works
Nguyen, V. T., Bevernage, J., Darville, N., Tistaert, C., Bocxlaer, J. V., Rossenu, S., & Vermeulen, A. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00948 · Cited by 12 · see citing works
Ignacio, R. B., Chew, K. W., Moser, C., Currier, J. S., Eron, J. J., Javan, A. C., Giganti, M. J., Aga, E., Gibbs, M. R. J., Kouekam, H. T., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.10039 · Cited by 11 · see citing works
Human Safety and Pharmacokinetic Study of Intramuscular Midazolam Administered by Autoinjector
Reichard, D. W., Atkinson, A. J., Hong, S. P., Burback, B. L., Corwin, M. J., & Johnson, J. D. (2010) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009358083 · Cited by 10 · see citing works
“In addition, body movement and activity can influence absorption.(19) These 2 factors may explain the slight difference between the present and previous study results because the former used the upper anterior thigh muscle for the injection site, and the participants were resting in bed prior to and following administ…”
ResultJohnson, A. R., Ballard, J. E., Leithead, A., Miller, C. O., Faassen, F., Zang, X., Nofsinger, R., & Wagner, A. M. (2023) · Pharmaceutical Research · doi:10.1007/s11095-023-03470-8 · Cited by 10 · see citing works
Lakeev, A. P., Yanovskaya, Е. А., Yanovsky, V. A., Олегович, А. М., Фрелих, Г. А., Chukicheva, I. Y., & Kuchin, A. V. (2022) · Journal of Chromatography B · doi:10.1016/j.jchromb.2022.123537 · Cited by 9 · see citing works
Comparative bioavailability study of two haloperidol decanoate containing products
van Weringh, G., Komen, B. J., Thieme, R. E., van der Hoeven, R. T. M., & Vos, T. (1994) · Pharmacy World & Science · doi:10.1007/bf02178564 · Cited by 8 · see citing works
Karna, S., Chambers, P., Singh, P. M., Lopez-Villalobos, N., & Kongara, K. (2021) · New Zealand Veterinary Journal · doi:10.1080/00480169.2021.1927231 · Cited by 8 · see citing works
Kadir, F., Seijsener, C. B. J., & Zuidema, J. (1992) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(92)90011-p · Cited by 8 · see citing works
Self-citationInjectable Nanoparticles for Efficient Drug Delivery
Rabinow, B. E., & Chaubal, M. V. (2006) · doi:10.1201/9780849374555-10 · Cited by 7 · see citing works
Translational studies on a ready-to-use intramuscular injection of penethamate for bovine mastitis
Tucker, I. G., Jain, R., Alawi, F., Nanjan, K., & Bork, O. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-017-0388-1 · Cited by 7 · see citing works
Pharmacokinetics of Follicle-Stimulating Hormone: Clinical Significance
Ben‐Rafael, Z., Levy, T., & Schoemaker, J. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00507-4 · Cited by 8 · see citing works
Excipient Selection and Criteria for Injectable Dosage Forms
Chaubal, M. V., Kipp, J., & Rabinow, B. E. (2006) · CRC Press eBooks · doi:10.1201/9781420004137-19 · Cited by 6 · see citing works
Østergaard, J., Mertz, N., Gancho, V., Le, A., Barber, M., Bezawada, P., Larsen, S. W., O’Brien, M. N., & Jaini, R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106412 · Cited by 5 · see citing works
Tsekouras, A. A., & Macheras, P. E. (2023) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-023-00831-x · Cited by 5 · see citing works
“However, the variation of time to maximum concentration, interpreted as FAT in this study, following different sites of injection is very well known [16].”
BackgroundNader, A., Alexander, E. L., Brintziki, D., Haggag, A. Z., Harrison, S. A., Hawes, I. A., Hezareh, M., Lippa, A. M., Okamasa, A., Okour, M., et al. (2023) · Clinical Pharmacokinetics · doi:10.1007/s40262-023-01319-2 · Cited by 5 · see citing works
“Several factors are known to affect exposure following IM administration, including BMI, sex, age, ethnicity, and adiposity around the injection site [18, 19].”
BackgroundKarna, S. R., Singh, P. M., Chambers, P., & Kongara, K. (2019) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.12831 · Cited by 5 · see citing works
Excipient Selection and Criteria for Injectable Dosage Forms
Chaubal, M. V., Kipp, J., Rabinow, B. E., & Gokarn, Y. R. (2006) · CRC Press eBooks · doi:10.1201/9781420004137.ch16 · Cited by 5 · see citing works
Injectable Nanoparticles for Efficient Drug Delivery
Chaubal, M. V., & Rabinow, B. E. (2006) · Drugs and the pharmaceutical sciences · doi:10.1201/9780849374555.ch8 · Cited by 4 · see citing works
Making ‘safer injecting’ matter for people who inject image and performance enhancing drugs
Piatkowski, T. M., Kill, E., Weith, S., Reeve, S., Cox, L. T. J., Coomber, R., Puljević, C., O’Connor, T., & Ferris, J. (2025) · Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine · doi:10.1177/13634593251388294 · Cited by 2 · see citing works
“Shallow injections, where the needle does not penetrate deeply enough into the muscle, can alter the drug’s release profile (Zuidema et al., 1988).”
Morris, N. M., Djehizian, A., Mittapelly, N., Telaprolu, K. C., Holland, B. W., McNally, K., Polak, S., Jamei, M., Alam, K. D., Tsakalozou, E., et al. (2026) · The AAPS Journal · doi:10.1208/s12248-026-01213-2 · Cited by 2 · see citing works
“Some published models have described the absorption of poorly soluble drugs after intra-muscular injection as dissolution rate-limited (12, 27, 28).”
El‐Zailik, A., Sager, J. E., Sánchez‐Pearson, Y., Parra, S., Moore, J., Sarkar, P., Aylott, A., Wang, Q., Aldinger, M., Garner, C., et al. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3515 · Cited by 2 · see citing works
“14 17 However, little is known about the impact of IM injection sites on the PK of mAbs.”
Biopharmaceutical Principles of Injectable Dispersed Systems
Oussoren, C., Zuidema, J., Kadir, F., & Talsma, H. (2005) · Drugs and the pharmaceutical sciences · doi:10.1201/9780849350610.ch2 · Cited by 2 · see citing works
Self-citationDissolution and Bioavailability
(1991) · Drugs and the pharmaceutical sciences · doi:10.1201/b14198-10 · Cited by 2 · see citing works
Pharmacokinetics of gonadotropin therapy
Levy, T., & Ben‐Rafael, Z. (1996) · Reproductive Medicine Review · doi:10.1017/s0962279900001216 · Cited by 2 · see citing works
Considerations for extrapolatingin vivobioequivalence data across species and routes
Modrić, S., Bermingham, E. C., Heit, M. C., Lainesse, C., & THOMPSON, C. (2012) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2012.01365.x · Cited by 1 · see citing works
“The effect of site can be even more pronounced for suspensions and oily solutions compared to aqueous solutions because these types of formulations have to undergo dissolution and phase transfer (rate-limiting steps) before the drug is available for absorption (Zuidema et al., 1988).”
BackgroundInfluentialKozlina, F., Meštrović, I., Novak, V., Marjanović, N., & Cetina‐Čižmek, B. (2022) · ADMET & DMPK · doi:10.5599/admet.1465 · Cited by 1 · see citing works
(2003) · Informa Healthcare eBooks · doi:10.1201/9780203009673.fmatt
Bouwman-Boer, Y., & Vermes, A. (2009) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-8032-9_35
Lee, J. Y., Cho, J. W., Kim, J. Y., Lee, H. J., Jeong, S. W., Cho, H. K., & Park, S. Y. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127289
- Authors
- Zuidema, J., Pieters, F. A. J. M., & Duchateau, G. S. M. J. E.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Zuidema, J.
- Pieters, F.A.J.M.
- Duchateau, G.S.M.J.E.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 47
- Issue
- 1-3
- Pages
- 1-12
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2066738943
- Cited by
- 72
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 5 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- intramuscular injection, drug absorption rate, injection depth, lipophilic drugs, depot effect, drug formulation, dissolution rate, phase transfer, drug release kinetics, mucosal absorption, gluteal region
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