Cited by 15Dementia and Cognitive Impairment ResearchEEG and Brain-Computer InterfacesAlzheimer's disease research and treatments

Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study

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Schjønning Nielsen, Malene, Simonsen, Anja Hviid, Siersma, Volkert, Engedal, Knut, Jelic, Vesna, Andersen, Birgitte Bo, Naik, Mala, Hasselbalch, Steen Gregers +1 more·2018·Dementia and Geriatric Cognitive Disorders Extra

Abstract

Aim: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. Methods: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls). Standardized EEG was performed at baseline. Patients were continuously clinically evaluated. Results: Receiver Operating Characteristic curves showed a low discriminative ability of SPR and no ability to predict clinical progression in patients with MCI. Moderate correlation between SPR analysis and CSF AD biomarkers was found. Conclusion: The diagnostic and prognostic abilities of qEEG were low. The SPR method was superior to the visual EEG analysis. The qEEG method correlates well to CSF AD biomarkers, suggesting association with pathology in AD.

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Authors
Schjønning Nielsen, M., Simonsen, A. H., Siersma, V., Engedal, K., Jelic, V., Andersen, B. B., Naik, M., Hasselbalch, S. G., & Høgh, P.
Affiliations
  • University of Copenhagen (DK)
  • Sykehuset i Vestfold (NO)
  • Zealand University Hospital (DK)
Venue
Dementia and Geriatric Cognitive Disorders Extra
Publisher
S. Karger AG
Published
2018-11-27
Volume
8
Issue
3
Pages
426-438
ISSN
1664-5464 (ISSN-L)
OpenAlex
W2903470474
Cited by
15
References
37
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2
FWCI
1.97
Type
journal article
Language
en
Open access
Locations
  • Dementia and Geriatric Cognitive Disorders Extra (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Velux Fonden
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
quantitative EEG, statistical pattern recognition, mild cognitive impairment, Alzheimer's disease, cerebrospinal fluid biomarkers, differential diagnosis, diagnostic accuracy

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