Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex
Abstract
Objective: The purpose of this study was to report on the prevalence and incidence of mild cognitive impairment (MCI) across age, sex, and subtypes according to various criteria in a population-based sample. Methods: The sample was drawn from the Swedish Good Aging in Skåne (GÅS) population study, and data from 3,752 participants aged 60 years and more were used to calculate the MCI prevalence. The incidence was calculated using 2,093 participants with 6-year follow-up data. MCI was defined according to the expanded Mayo Clinic criteria: cognitive complaint, objective cognitive impairment (two different criteria depending on the severity of impairment), preserved functional abilities, and no dementia. Results: The prevalence estimates ranged from 5.13 to 29.9% depending on age and severity of impairment. The incidence rates of overall MCI were 22.6 (95% confidence interval [CI]: 19.6–25.9) and 8.67 (95% CI: 7.0–10.7) per 1,000 person-years for less severe and severe cognitive impairment, respectively. The highest prevalence and incidence estimates were found for “non-amnestic MCI single domain.” The older age groups had a higher prevalence, and no sex or age differences in MCI incidence were detected. Conclusion: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment.
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The levels of Alzheimer's disease plasma biomarkers are affected by several factors including age, sex and comorbidities.
“It is known that the levels of Alzheimer’s disease plasma biomarkers are affected by several factors including age, sex and comorbidities55.”
From Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain β-amyloid pathology (2023) · cites this paper as [55]
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Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00236-x · Cited by 74 · see citing works
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“It is known that the levels of Alzheimer ’ s disease plasma biomarkers are affected by several factors including age, sex and comorbidities 55 .”
- Authors
- Overton, M., Pihlsgård, M., & Elmståhl, S.
- Affiliations
- Lund University (SE)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2019
- Volume
- 47
- Issue
- 4-6
- Pages
- 219-232
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2958614151
- Cited by
- 134
- References
- 4
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 28 · 2023: 22 · 2022: 26 · 2021: 22 · 2020: 7 · 2019: 2
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- mild cognitive impairment, prevalence, incidence, MCI subtypes, cognitive impairment severity, age differences, sex differences, Mayo Clinic criteria, older adults
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Reference Values, Sex Factors, Sweden, Incidence, Prevalence, Cognitive Dysfunction
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