Transcranial Magnetic and Direct Current Stimulation in the Treatment of Depression: Basic Mechanisms and Challenges of Two Commonly Used Brain Stimulation Methods in Interventional Psychiatry
Open accessAbstract
Noninvasive neuromodulation, including repetitive trans-cranial magnetic stimulation (rTMS) and direct current stimulation (tDCS), provides researchers and health care professionals with the ability to gain unique insights into brain functions and treat several neurological and psychiatric conditions. Undeniably, the number of published research and clinical papers on this topic is increasing exponentially. In parallel, several methodological and scientific caveats have emerged in the transcranial stimulation field; these include less robust and reliable effects as well as contradictory clinical findings. These inconsistencies are maybe due to the fact that research exploring the relationship between the methodological aspects and clinical efficacy of rTMS and tDCS is far from conclusive. Hence, additional work is needed to understand the mechanisms underlying the effects of magnetic stimulation and low-intensity transcranial electrical stimulation (TES) in order to optimize dosing, methodological designs, and safety aspects.
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Skepticism is increased by lack of clear theories and evidence on working mechanisms of both interventions, which hampers smart applications.
“Skepticism is increased by lack of clear theories and evidence on working mechanisms of both interventions, which hampers smart applications (Chase, Boudewyn, Carter, & Phillips, 2020; Singh, Erwin-Grabner, Goya-Maldonado, & Antal, 2019)”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Singh, Erwin-Grabner, Goya-Maldonado, & Antal, 2019
Cites
McClintock, S. M., Reti, I. M., Carpenter, L. L., McDonald, W. M., Dubin, M., Taylor, S. F., Cook, I. A., O’Reardon, J., Husain, M. M., Wall, C., et al. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16cs10905 · Cited by 693 · see citing works
Neural correlates of rumination in depression
Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H. (2010) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.10.4.470 · Cited by 493 · see citing works
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Begemann, M. J., Brand, B. A., Ćurčić-Blake, B., Aleman, A., & Sommer, I. E. (2020) · Psychological Medicine · doi:10.1017/s0033291720003670 · Cited by 368 · see citing works
Canbeyli, R. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15507 · Cited by 48 · see citing works
- Authors
- Singh, A., Erwin-Grabner, T., Goya-Maldonado, R., & Antal, A.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2019-09-05
- Volume
- 79
- Issue
- 6
- Pages
- 397-407
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2977487360
- Cited by
- 23
- References
- 4
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 6
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- repetitive transcranial magnetic stimulation, transcranial direct current stimulation, depression treatment, non-invasive brain stimulation, neuromodulation mechanisms, stimulation parameters, methodological design, treatment efficacy, stimulation safety
- MeSH terms
- Depressive Disorder, Humans, Psychiatry, Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
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