Neural correlates of rumination in depression
Open accessAbstract
Rumination, or recursive self-focused thinking, has important implications for understanding the development and maintenance of depressive episodes. Rumination is associated with the worsening of negative mood states, greater affective responding to negative material, and increased access to negative memories. The present study was designed to use fMRI to examine neural aspects of rumination in depressed and healthy control individuals. We used a rumination induction task to assess differences in patterns of neural activation during ruminative self-focus as compared with a concrete distraction condition and with a novel abstract distraction condition in 14 participants who were diagnosed with major depressive disorder and 14 healthy control participants. Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. Neural activity during rumination versus abstract distraction was greater for depressed than for control participants in the amygdala, rostral anterior cingulate/medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate, and parahippocampus. These findings indicate that ruminative self-focus is associated with enhanced recruitment of limbic and medial and dorsolateral prefrontal regions in depression. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.
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One of the most frequently reported neuroimaging findings in MDD is abnormally increased connectivity and heightened activation of the amygdala.
“One of the most frequently reported neuroimaging findings in MDD is abnormally increased connectivity and heightened activation of the amygdala 99-101 .”
From Major depressive disorder (2016) · cites this paper as [100]
The Between-groups activations section reports greater amygdala activation in MDD participants than in controls during rumination versus abstract distraction. It does not report increased amygdala connectivity or establish that these are among the most frequently reported neuroimaging findings in MDD. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTask-based studies examining trait levels of worry or depressive rumination or instructions to worry or ruminate demonstrate neural activations in nodes of the DN.
“Similarly, task-based studies examining trait levels of worry or depressive rumination (e.g., Paulus and Stein, 2010; Hamilton et al., 2011) or instructions to worry or ruminate (e.g., Cooney et al., 2010; Paulus and Stein, 2010; Ottaviani et al., 2016) demonstrate neural activations in nodes of the DN.”
From Distinct functional connectivities predict clinical response with emotion regulation therapy (2017) · cites this paper as Cooney et al., 2010
Decreased frontoparietal connectivity has been found both at rest and in response to negative stimuli, but not in response to positive stimuli.
“Moreover, decreased frontoparietal connectivity has been found both at rest and in response to negative stimuli, but not in response to positive stimuli, suggesting that this network may contribute to inappropriate cognitive appraisals of negative events more specifically 100,105 .”
From Major depressive disorder (2016) · cites this paper as [100]
The Between-groups activations section reports regional activation differences, not frontoparietal connectivity at rest or in response to negative stimuli. It also states that the study presented only neutral statements and that responses to positive and negative stimuli require further research. Searches for frontoparietal and functional connectivity found no passage establishing the claimed pattern; page numbers were unavailable in our copy. (LLM, conf=0.77)
Experimental — accuracy not yet measured
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“…present study, α = .94. fMRI stimulus presentation Rumination paradigm The fMRI rumination task was based on the principles of previous studies (i.e., Cooney et al., 2010; Johnson et al., 2006; Lyubomirsky & Nolen-Hoeksema, 1993) and was modified to include a negative mood induction to facilitate…”
InfluentialEmotion regulation and the salience network: a hypothetical integrative model of fibromyalgia
Pinto, A. M., Geenen, R., Wager, T. D., Lumley, M. A., Häuser, W., Kosek, E., Ablin, J. N., Amris, K., Branco, J., Buskila, D., et al. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00873-6 · Cited by 152 · see citing works
Neural substrates of trait ruminations in depression.
Mandell, D., Siegle, G. J., Shutt, L. S., Feldmiller, J., & Thase, M. E. (2014) · Journal of Abnormal Psychology · doi:10.1037/a0035834 · Cited by 137 · see citing works
“Depressed participants show greater activation than controls in these areas during experirnentally induced rumination (Cooney et al., 2010); however, they also show increased activation of the amygdala.”
BackgroundBeblo, T., Sinnamon, G., & Baune, B. T. (2011) · Neuropsychology Review · doi:10.1007/s11065-011-9171-0 · Cited by 128 · see citing works
“Cooney et al. (2010) suggested that rumination in MDD patients is associated with enhanced recruitment of limbic and medial and dorsolateral prefrontal regions.”
BackgroundAlderman, B. L., Olson, R. L., Brush, C. J., & Shors, T. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.225 · Cited by 125 · see citing works
Rumination and Worry in Daily Life
Kircanski, K., Thompson, R. J., Sorenson, J. E., Sherdell, L., & Gotlib, I. H. (2015) · Clinical Psychological Science · doi:10.1177/2167702614566603 · Cited by 124 · see citing works
Self-citationTeng, C., Zhou, J., Ma, H., Tan, Y., Wu, X., Guan, C., Qiao, H., Li, J., Zhong, Y., Wang, C., et al. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1955-9 · Cited by 124 · see citing works
The neurobiology of treatment-resistant depression: A systematic review of neuroimaging studies
Runia, N., Yücel, D. E., Lok, A., de Jong, K., Denys, D. A. J. P., van Wingen, G. A., & Bergfeld, I. O. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.008 · Cited by 117 · see citing works
“Furthermore, several studies show abnormally increased activity in DMN regions during rumination in MDD compared to healthy controls (Burkhouse et al., 2017; Cooney et al., 2010).”
He, H., Yu, Q., Du, Y., Vergara, V. M., Victor, T. A., Drevets, W. C., Savitz, J. B., Jiang, T., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., & Calhoun, V. D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.042 · Cited by 116 · see citing works
“rumination (Cooney et al., 2010), which may associate with both BD and MDD (Johnson et al.”
BackgroundChen, X., Chen, N.-X., Shen, Y., Li, H., Li, L., Lu, B., Zhu, Z.-C., Fan, Z., & Yan, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117185 · Cited by 110 · see citing works
“…versus distraction, which is a control condition requiring participants to focus on externally oriented thoughts that are unrelated to themselves (Burkhouse et al., 2016; Cooney et al., 2010; Freton et al., 2014; Johnson et al., 2009; Johnson et al., 2006; Nolen-hoeksema and Morrow, 1993).”
InfluentialGender differences in neural correlates of stress-induced anxiety
Seo, D., Ahluwalia, A., Potenza, M. N., & Sinha, R. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23926 · Cited by 114 · see citing works
“Consistent with the above interpretation, evidence suggests that the medial PFC, including the dmPFC, is involved in self-referential thinking, rumination, and depression (Cooney et al., 2010; Nejad et al., 2013).”
ResultJacobs, R. H., Jenkins, L. M., Gabriel, L. B., Barba, A., Ryan, K. A., Weisenbach, S. L., Verges, A., Baker, A. M., Peters, A. T., Crane, N. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104366 · Cited by 109 · see citing works
“, [21]) as well as evidence that the sgACC contributes to ruminative processes [30], we conducted exploratory analyses testing whether self-report rumination was correlated with aberrant connectivities among rMDD youth.”
MethodSelf-citationPhilip, N. S., Barredo, J., Aiken, E., & Carpenter, L. L. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.10.007 · Cited by 111 · see citing works
“Compared to controls at baseline, patients had greater sgACC connectivity with the DLPFC and precuneus (consistent with (56)).”
BackgroundResultShen, X., Howard, D. M., Adams, M. J., Hill, W. D., Clarke, T.-K., Adams, M. J., Clarke, T., McIntosh, A. M., Deary, I. J., Wray, N. R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16022-0 · Cited by 111 · see citing works
Mood-congruent memory revisited.
Faul, L., & LaBar, K. S. (2022) · Psychological Review · doi:10.1037/rev0000394 · Cited by 112 · see citing works
Neural correlates of rumination in major depressive disorder: A brain network analysis
Jacob, Y., Morris, L. S., Huang, K.-H., Schneider, M., Rutter, S., Verma, G., Murrough, J. W., & Balchandani, P. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102142 · Cited by 110 · see citing works
“Two seed-based functional connectivity studies have shown that rumination is associated with higher connectivity between a PCC seed region and subgenual ACC, and lower connectivity between a subgenual ACC seed region and the medial frontal cortex (5, 25).”
InfluentialHankin, B. L. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.711708 · Cited by 107 · see citing works
Neural correlates of tinnitus related distress: An fMRI-study
Golm, D., Schmidt‐Samoa, C., Dechent, P., & Kröner‐Herwig, B. (2012) · Hearing Research · doi:10.1016/j.heares.2012.03.003 · Cited by 106 · see citing works
The neural correlates of worry in association with individual differences in neuroticism
Servaas, M. N., Riese, H., Ormel, J., & Aleman, A. (2014) · Human Brain Mapping · doi:10.1002/hbm.22476 · Cited by 96 · see citing works
“[2010] and other studies demonstrating the involvement of the default mode network and brain regions related to emotion processing and regulation in state as well as trait worry and rumination [Andreescu et al., 2011; Berman et al., 2011; Cooney et al., 2010; Hamilton et al., 2011; Marchetti et al., 2012; Paul et al.,…”
BackgroundYoga and Mindfulness as Therapeutic Interventions for Stroke Rehabilitation: A Systematic Review
Lazaridou, A., Philbrook, P., & Tzika, A. A. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/357108 · Cited by 92 · see citing works
Marchand, W. R., Lee, J. N., Johnson, S., Thatcher, J. W., Gale, P. D., Wood, N., & Jeong, E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.10.016 · Cited by 92 · see citing works
“…the relationship between aberrant selfreferential thinking and negative affect in mood disorders (Altshuler et al., 2005, 2008; Chen et al., 2006; Cooney et al., 2010; Elliott et al., 2004; Grimm et al., 2009a, 2009b; Lagopoulos and Malhi, 2011; Lemogne et al., 2010; Lennox et al., 2004; Malhi…”
BackgroundBelleau, E. L., Taubitz, L. E., & Larson, C. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu117 · Cited by 92 · see citing works
“Previous studies have found that compared with the external-focus condition, the self-focus condition used in this paradigm effectively generates rumination in depressed individuals (Lyubomirsky and Nolen-Hoeksema, 1993; NolenHoeksema and Morrow, 1993) and differentiates those with and without MDD on levels of neural…”
BackgroundMethodResultInfluentialLe, T. M., Borghi, J., Kujawa, A., Klein, D. N., & Leung, H. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.004 · Cited by 91 · see citing works
“Published by Elsevier Inc a b s t r a c t a r t i c l e i n f o Article history: Received 4 September 2016 Received in revised form 13 December 2016 Accepted 4 January 2017 Available online 07 January 2017 The present study examined the impacts of major depressive disorder (MDD) on visual and…”
Increased involvement of the parahippocampal gyri in a sad mood predicts future depressive symptoms
Zamoscik, V., Huffziger, S., Ebner‐Priemer, U., Kuehner, C., & Kirsch, P. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu006 · Cited by 87 · see citing works
“Furthermore, Cooney and colleagues found greater activity in the PHG during rumination versus abstract distraction in depressive patients in contrast to healthy controls (Cooney et al., 2010).”
The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review
Kakarala, S. E., Roberts, K. E., Rogers, M., Coats, T., Falzarano, F., Gang, J., Chilov, M., Avery, J., Maciejewski, P. K., Lichtenthal, W. G., et al. (2020) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2020.111135 · Cited by 85 · see citing works
Chahal, R., Gotlib, I. H., & Guyer, A. E. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13250 · Cited by 80 · see citing works
Self-citationA two-factor model of relapse/recurrence vulnerability in unipolar depression
Farb, N. A. S., Irving, J. A., Anderson, A. K., & Segal, Z. V. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000031 · Cited by 75 · see citing works
Messina, I., Grecucci, A., & Viviani, R. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab007 · Cited by 66 · see citing works
Das, P., Calhoun, V. D., & Malhi, G. S. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.04.062 · Cited by 77 · see citing works
“rumination where a decrease in emotion clarity is associated with an increase in activity in the vmPF (Cooney et al., 2010).”
Aberrant functional connectivity in depression as an index of state and trait rumination
Rosenbaum, D., Haipt, A., Fuhr, K., Haeussinger, F. B., Metzger, F. G., Nuerk, H., Fallgatter, A. J., Batra, A., & Ehlis, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-02277-z · Cited by 77 · see citing works
Stress-related dysfunction of the right inferior frontal cortex in high ruminators: An fNIRS study
Rosenbaum, D., Thomas, M., Hilsendegen, P., Metzger, F., Haeussinger, F. B., Nuerk, H.-C., Fallgatter, A., Nieratschker, V., & Ehlis, A. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.02.022 · Cited by 74 · see citing works
“, dorsolateral prefrontal cortex (dlPFC)) can be elicited by a rumination induction (Cooney et al., 2010).”
van Wingen, G. A., Tendolkar, I., Urner, M., van Marle, H. J. F., Denys, D. A. J. P., Verkes, R., & Fernández, G. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.022 · Cited by 75 · see citing works
“, 2012), and increased activity in the DLPFC and increased connectivity with the MPFC during self-referential processing, as well as increased DLPFC activity during instructed rumination (Cooney et al., 2010; Lemogne et al., 2009).”
BackgroundAmygdala subregions tied to SSRI and placebo response in patients with social anxiety disorder
Faria, V., Appel, L., Åhs, F., Linnman, C., Pissiota, A., Frans, Ö., Bani, M., Bettica, P., Pich, E. M., Jacobsson, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.72 · Cited by 73 · see citing works
Dipasquale, O., Selvaggi, P., Veronese, M., Gabay, A. S., Turkheimer, F., & Mehta, M. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.007 · Cited by 68 · see citing works
Fowler, C. H., Miernicki, M. E., Rudolph, K. D., & Telzer, E. H. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.09.002 · Cited by 71 · see citing works
“I Can’t Give Up When I Have Them to Care for”: People’s Experiences of Pets and Their Mental Health
Hawkins, R. D., Hawkins, E. L., & Tip, L. M. (2021) · Anthrozoös · doi:10.1080/08927936.2021.1914434 · Cited by 72 · see citing works
“These have been proven to be helpful for mental health by a large body of research (e.g., Arditte Hall et al., 2019; Cooney et al., 2010).”
BackgroundDifferences in functional connectivity in major depression versus bipolar II depression
Marchand, W. R., Lee, J. N., Johnson, S., Gale, P. D., & Thatcher, J. W. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.028 · Cited by 71 · see citing works
“Considerable evidence indicates that CMS structures play a direct role in mediating the relationship between aberrant self-referential thinking and negative affect in mood disorders (Altshuler et al., 2005, 2008; Chen et al., 2006; Cooney et al., 2010; Elliott et al., 2004; Grimm et al., 2009a, 2009b; Lagopoulos and M…”
BackgroundFunctional connectivity of reflective and brooding rumination in depressed and healthy women
Satyshur, M. D., Layden, E., Gowins, J. R., Buchanan, A., & Gollan, J. (2018) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-0611-7 · Cited by 67 · see citing works
“Of note, one study did find increased activity in the middle occipital region when participants performed a rumination task (Cooney et al., 2010).”
BackgroundRegional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression
Liu, C., Ma, X., Wu, X., Zhang, Y., Zhou, F., Li, F., Tie, C.-L., Dong, J., Wang, Y., Yang, Z., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.010 · Cited by 72 · see citing works
Wang, S. B., Lydecker, J. A., & Grilo, C. M. (2017) · European Eating Disorders Review · doi:10.1002/erv.2499 · Cited by 73 · see citing works
Review on Neural Correlates of Emotion Regulation and Music: Implications for Emotion Dysregulation
Hou, J.-C., Song, B., Chen, A. C., Sun, C.-G., Zhou, J.-X., Zhu, H.-D., & Beauchaine, T. P. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00501 · Cited by 69 · see citing works
“In fact, emotion dysregulation characterizes most psychiatric disorders (Beauchaine, 2015a,b; Beauchaine and Thayer, 2015), including internalizing disorders (Mayberg et al., 2005; Cooney et al., 2010; Rajappa et al., 2012; Miranda et al., 2013), externalizing disorders (Beauchaine et al.”
BackgroundDo sex differences in rumination explain sex differences in depression?
Shors, T. J., Millon, E. M., Chang, H. Y. M., Olson, R. L., & Alderman, B. L. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23976 · Cited by 70 · see citing works
“In one study, individuals with depression expressed more activation in the right hippocampus when engaging in a digit-sorting task during experimentally-induced rumination (Cooney et al., 2010).”
BackgroundSiep, N., Tonnaer, F., van de Ven, V., Arntz, A., Raine, A., & Cima, M. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9945-6 · Cited by 77 · see citing works
Psychedelic therapy's transdiagnostic effects: A research domain criteria (RDoC) perspective
Kelly, J. R., Gillan, C. M., Prenderville, J., Kelly, C., Harkin, A., Clarke, G., & O'Keane, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.800072 · Cited by 69 · see citing works
Lois, G., & Wessa, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw085 · Cited by 66 · see citing works
“Rumination-induction has been associated with increased DMN functional connectivity (FC) and hyperactivity in MDD patients (Lemogne et al., 2009; Cooney et al., 2010; Kessler et al., 2011; Berman et al., 2014) and healthy subjects (Kross et al.”
BackgroundLi, H., Li, W., Wei, D., Chen, Q., Jackson, T., Zhang, Q., & Qiu, J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.044 · Cited by 68 · see citing works
“PHG dysfunction has been linked to PTSD (Cooney et al., 2010), social anxiety disorder (Etkin andWager, 2007), Alzheimer's disease and schizophrenia (Bilkey, 2004).”
InfluentialRumination network dysfunction in major depression: A brain connectome study
Zhang, R., Kranz, G. S., Zou, W., Deng, Y., Huang, X., Lin, K., & Lee, T. M. C. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109819 · Cited by 69 · see citing works
“Rumination involves a broad range of cognitive and affective processes including self-referential processing, autobiographical memories, and emotion regulation (Cooney et al., 2010; Sin et al., 2018).”
InfluentialThe neural basis of unwanted thoughts during resting state.
Kühn, S., Vanderhasselt, M., de Raedt, R., & Gallinat, J. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst117 · Cited by 64 · see citing works
“The existing neuroimaging studies that focussed on unwanted thoughts in the broadest sense have mostly investigated the trait aspects of rumination and have presented task-related fMRI data in which patients with mental disorders were compared with healthy controls (Ray et al., 2005; Berman et al., 2011; Cooney et al.…”
BackgroundGorka, A. X., Torrisi, S., Shackman, A. J., Grillon, C., & Monique Ernst, D. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.007 · Cited by 62 · see citing works
“…direct anatomical projections to the CeA and BNST, such as the dorsolateral prefrontal cortex or posterior cingulate, are involved with the cognitive processing of negative information (Berman et al., 2010; Cooney et al., 2010), and may be highly relevant to subjective feelings of fear and anxiety.”
Lin, Y., Callahan, C. P., & Moser, J. S. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.007 · Cited by 65 · see citing works
Alonso, S., Deco, G., Horst, G. J. T., & Cabral, J. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.570583 · Cited by 58 · see citing works
Basal Hippocampal Activity and Its Functional Connectivity Predicts Cocaine Relapse
Adinoff, B. H., Gu, H., Merrick, C., McHugh, M. J., Jeon‐Slaughter, H., Lu, H., Yang, Y., & Stein, E. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.027 · Cited by 64 · see citing works
“The heightened rumination in depressed individuals, for example, is associated with increased PCC activity during a rumination task (67) and PCC-anterior cingulate connectivity at rest (68), and in cocaine-dependent individuals, PCC activation is associated with cue-induced craving (69).”
BackgroundFerdek, M. A., van Rijn, C. M., & Wyczesany, M. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0456-x · Cited by 63 · see citing works
“Cooney et al. (2010) found enhanced amygdala, parahippocampal, and temporal gyri (middle temporal gyrus and superior temporal gyrus) activation in depressed patients compared to healthy controls during the ruminative versus abstract condition.”
InfluentialHenje, E., Duncan, L. G., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Chesney, M. A., Hecht, F. M., & Yang, T. T. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00630 · Cited by 63 · see citing works
“Depressed individuals often ruminate and have difficulties disengaging from the processing of self-focused, often negatively biased thoughts (Cooney et al., 2010; Manoliu et al., 2013; Mandell et al., 2014).”
BackgroundNicotine and networks: Potential for enhancement of mood and cognition in late-life depression
Gandelman, J. A., NEWHOUSE, P. A., & Taylor, W. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.018 · Cited by 61 · see citing works
“, 2009) and during maladaptive ruminative self-focus (Cooney et al., 2010).”
Luo, X., Chen, G., Jia, Y., Gong, J., Qiu, S., Zhong, S., Zhao, L., Chen, F., Lai, S., Qi, Z., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00705 · Cited by 62 · see citing works
Peterson, B. S., Wang, Z., Horga, G., Warner, V., Rutherford, B. R., Klahr, K., Graniello, B., WICKRAMARATNE, P. J., Garcia, F., Yu, S., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4048 · Cited by 60 · see citing works
Fischer, A. S., Keller, C. J., & Etkin, A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.02.004 · Cited by 60 · see citing works
“DMN hyperconnectivity strongly correlates with measures of self-rumination (23,56), as well as with disease severity and duration (57).”
BackgroundPhilippi, C. L., Cornejo, M. D., Frost, C. P., Walsh, E. C., Hoks, R. M., Birn, R., & Abercrombie, H. C. (2018) · Human Brain Mapping · doi:10.1002/hbm.24003 · Cited by 60 · see citing works
“…studies in MDD suggest that aberrant activity in these self-related brain regions, in particular the mPFC and ACC, may underlie negative-SFT in MDD (Cooney, Joormann, Eugène, Dennis, & Gotlib, 2010; Grimm et al., 2009; Johnson, Nolen-Hoeksema, Mitchell, & Levin, 2009; Lemogne et al., 2009; Nejad,…”
BackgroundHsu, D. T., Mickey, B. J., Langenecker, S. A., Heitzeg, M. M., Love, T., Wang, H., Kennedy, S. E., Peciña, M., Shafir, T., Hodgkinson, C. A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5533-11.2012 · Cited by 60 · see citing works
“Similar to our results, increased subgenual BOLD activity in MDD participants has been observed while viewing sad faces (Gotlib et al., 2005) and during rumination (Cooney et al., 2010) compared with controls.”
BackgroundResultInsular subdivisions functional connectivity dysfunction within major depressive disorder
Peng, X., Lin, P., Wu, X., Gong, R., Yang, R., & Wang, J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.018 · Cited by 60 · see citing works
Changes in functional connectivity following treatment with emotion regulation therapy
Scult, M. A., Fresco, D. M., Gunning, F. M., Liston, C., Seeley, S. H., García, E., & Mennin, D. S. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00010 · Cited by 57 · see citing works
- Authors
- Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- University of Miami (US)
- Concordia University (CA)
- Corresponding author
- Cooney, Rebecca E.
- Venue
- Cognitive, Affective, & Behavioral Neuroscience
- Published
- 2010-12
- Volume
- 10
- Issue
- 4
- Pages
- 470-478
- ISSN
- 1530-7026 (ISSN-L)
- 1531-135X
- PMC
- PMC4476645
- OpenAlex
- W2083730492
- Semantic Scholar
- 7cfcec0eec853fe3db0b31fdaa15113a4a7fe039
- Cited by
- 493
- References
- 44
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 36 · 2023: 33 · 2022: 41 · 2021: 45 · 2020: 41 · 2019: 34 · 2018: 29 · 2017: 28 · 2016: 23 · 2015: 28 · 2014: 27 · 2013: 25 · 2012: 30
- FWCI
- 27.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cognitive Affective & Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH59259, R01MH059259)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- rumination, major depressive disorder, neural correlates, orbitofrontal cortex, subgenual anterior cingulate cortex, dorsolateral prefrontal cortex, amygdala, limbic system, medial prefrontal cortex, posterior cingulate cortex, parahippocampal cortex
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Reaction Time, Thinking, Young Adult
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