The International Atomic Energy Agency International Doubly Labelled Water Database: Aims, Scope and Procedures
Open accessAbstract
Background: The doubly labelled water (DLW) method is an isotope-based technique that quantifies total energy expenditure (TEE) over periods of 1–3 weeks from the differential elimination of stable isotopes of oxygen and hydrogen. The method was invented in the 1950s, but limited ability to measure low isotope enrichments combined with the high cost of isotopes meant it only became feasible to use in humans in the 1980s. It is still relatively expensive to use, and alone small samples are unable to tackle some of the important questions surrounding energy balance such as how have expenditures changed over time and how do expenditures differ with age, between sexes and in different environments? Summary: By combining information across studies, answers to such questions may be possible. The International Atomic Energy Agency (IAEA) DLW database was established to pool DLW data across multiple studies. It was initiated by the main labs currently using the method and is hosted by the IAEA. At present, the database contains 6,621 measures of TEE by DLW from individuals in 23 countries, along with various additional data on the study participants. Key Messages: The IAEA DLW database is a key resource enabling future studies of energy demands.
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- Authors
- Speakman, J. R., Pontzer, H., Rood, J., Sagayama, H., Schoeller, D. A., Westerterp, K. R., Wong, W. W., Yamada, Y., Loechl, C., & Murphy-Alford, A. J.
- Affiliations
- University of Aberdeen (GB)
- Duke University (US)
- Pennington Biomedical Research Center (US)
- University of Tsukuba (JP)
- University of Wisconsin–Madison (US)
- Maastricht University (NL)
- Baylor College of Medicine (US)
- National Institute of Health and Nutrition (JP)
- International Atomic Energy Agency (AT)
- ORCID
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2019
- Volume
- 75
- Issue
- 2
- Pages
- 114-118
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2989870306
- Cited by
- 50
- References
- 8
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 4
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Nutrition and Metabolism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- National Science Foundation (1824466)
- International Atomic Energy Agency
- Japan Society for the Promotion of Science (18K17882)
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- doubly labeled water, total energy expenditure, energy balance, data pooling, stable isotope tracers, hydrogen and oxygen isotopes, energy requirements, age and sex differences
- MeSH terms
- Adult, Body Weight, Breast Feeding, Energy Intake, Deuterium, Energy Metabolism, Female, Humans, Infant, International Agencies, Male, Oxygen Isotopes, Pregnancy, Water Supply, Databases, Factual, Malnutrition, Overnutrition
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