The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Parasite Infections, Allergy and Asthma: A Role for Tropomyosin in Promoting Type 2 Immune Responses
Abstract
Introduction: The relationship of parasite infections and promotion or protection from allergy and asthma is controversial. Currently, over 1.5 billion people are infected with parasites worldwide, and Ascaris lumbricoides is the most frequent soil-transmitted helminth. Objectives: To evaluate the biological activity of recombinant A. lumbricoides tropomyosin and investigate IgE cross-reactive responses to tropomyosins by means of microarray methodology for the detection of sensitization to allergen components. Methods: Forty patients 12–75 years of age (25 males) with asthma and/or rhinitis and 10 nonallergic control subjects participated in this study. All patients presented positive skin tests to cockroach extracts and underwent skin prick testing (SPT) with recombinant (r) tropomyosins rPer a 7 from Periplaneta americana and rAsc l 3 from A. lumbricoides, at 10 μg/mL. IgE to cockroach and parasite tropomyosins were measured by chimeric ELISA and ImmunoCAP-ISAC, and total IgE was quantitated by ImmunoCAP. Agreement of results was assessed by κ statistics. Results: Recombinant A. lumbricoides showed biological activity, inducing positive skin tests in 50% patients with asthma and/or rhinitis. IgE to cockroach and parasite tropomyosins were detected in 55–62% of patients. There was good-to-excellent agreement of results of SPT and IgE measurements by ELISA and ImmunoCAP-ISAC, with κ indices of 0.66–0.95. No skin test reactivity or IgE antibodies to tropomyosins were found in nonallergic individuals. Conclusions: Our results suggest that IgE responses to tropomyosin from A. lumbricoides may enhance reactivity to homologous allergens upon exposure by inhalation or ingestion, promoting allergic reactions and asthma, or increasing the severity of these clinical conditions.
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In the citing paper
“Conserved invertebrate proteins, including tropomyosin and related muscle proteins, may have become targets of IgE responses because of long-term exposure to arthropods and other metazoan parasites.”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“Tropomyosins are among the most important examples of cross-reactive invertebrate allergens. They are characterized by high thermostability, resistance to digestion, and strong structural conservation across different invertebrate species.”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“Thus, persistent exposure to both endoparasites and ectoparasites may have played a crucial role in shaping and preserving IgE-mediated immune responses, mast cell activation, eosinophilic inflammation, and itch-associated protective behaviors, all of which are central to both parasite defense and allergic reactions (Farnell et al. 2015; Santiago et al. 2015; Sousa-Santos et al. 2020).”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“Tropomyosins may be involved in cross-reactions between crustaceans, mollusks, dust mites, cockroaches, and nematodes such as Ascaris lumbricoides (Asc l 3).”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“The homology between Ascaris tropomyosin and mite tropomyosins, including Der p 10 and Blo t 10, may contribute to cross-reactive IgE responses and complicate the interpretation of dust mite sensitization in parasite-exposed individuals (Cheng et al. 2022; Shafique et al. 2012; Sousa-Santos et al. 2020).”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“This may decrease mast cell and basophil degranulation and thereby reduce immediate hypersensitivity responses”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“Chronic helminth exposure may also promote IgG4 production”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
In the citing paper
“which can counterbalance IgE-mediated responses by competing with IgE for binding to shared allergen epitopes and reducing allergen-driven cross-linking of FcεRI-bound IgE on mast cells and basophils”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Sousa-Santos et al. 2020
Citations
Cites
Global issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Research works printed but not linked: 21
- 10.1111/pim.12589 · DOI
- 10.1016/j.iac.2019.03.009 · DOI
- 10.1111/pim.12588 · DOI
- 10.4269/ajtmh.16-0348 · DOI
- 10.1016/j.actatropica.2016.12.002 · DOI
- 10.1111/pim.12595 · DOI
- 10.1186/s40413-015-0058-z · DOI
- 10.1111/cea.12513 · DOI · Paper page
- 10.1016/j.jaci.2007.12.1147 · DOI
- 10.1159/000321106 · DOI · Paper page
- 10.1159/000346318 · DOI
- 10.1034/j.1398-9995.2003.00167.x · DOI
- 10.1007/s11882-017-0694-1 · DOI
- 10.18176/jiaci.0378 · DOI
- 10.1016/j.jaip.2018.04.035 · DOI
- 10.1016/j.jaip.2018.08.008 · DOI
- 10.1097/ACI.0000000000000529 · DOI
- 10.1097/ACI.0000000000000568 · DOI
- 10.1111/j.1365-2222.2009.03433.x · DOI · Paper page
- 10.1111/j.1365-2222.2012.04063.x · DOI · Paper page
- 10.1159/000431360 · DOI · Paper page
Cited by
Sorted by citations
Packi, K., Świerczewski, D., Klimczak, S., Ochab, D., Gałęziewska, J., Gromek, P., Kruczkowska, W., Płuciennik, E., Kałuzińska-Kołat, Ż., & Kołat, D. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02425-4
Metadata
- Authors
- Sousa-Santos, A. C. A. F., Moreno, A. S., Santos, A. B. R., Barbosa, M. C. R., Aragon, D. C., Sales, V. S. F., & Arruda, L. K.
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2019-12-19
- Volume
- 181
- Issue
- 3
- Pages
- 221-227
- ISSN
- 1018-2438
- 1423-0097
- Cited by
- 13
- References
- 1
- Language
- en
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