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Cited by 8Potassium and Related DisordersIon channel regulation and functionCardiac electrophysiology and arrhythmias

Periodic Paralysis: A Case Series with a Literature Review

Open access
Al Hariri, Bassem, Hassan, Muad Abdi, Sharif, Muhammad, Alsakaji, Obada Adel, Hassan, Yussuf Abdi, Khalid, Muayad Kasim·2024·Case Reports in Neurology
DOI 10.1159/000541585PMC PMC11501104
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Abstract

Introduction: Periodic paralysis is a condition that causes recurrent episodes of flaccid paralysis, and it can be primary or secondary. Hypokalemic periodic paralysis is the most common type of primary periodic paralysis, and it is inherited through autosomal dominant gene transmission. Males are affected three times more often than females, and the paralysis attacks usually occur at night after a period of vigorous exercise. It is crucial to exclude other diagnostic entities based on the nature of presentation, physical examination, and paraclinical studies. Thyrotoxic periodic paralysis is more prevalent in Asian or Hispanic males with thyrotoxicosis, where up to 10% of thyrotoxic patients may experience periodic paralysis. Case Presentations: Here, we present 6 cases of patients who came to our care with varying degrees of muscle weakness, each showing interesting and diverse laboratory results. Conclusion: In patient assessment, it is crucial to consider social and family history. Even without this information, awareness of potential diagnoses is vital. The cause should be carefully considered for possible simple treatments. Failing to recognize and address this condition promptly could lead to severe outcomes. Timely identification and intervention are essential for effective disease management and patient welfare.

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Crossref · 10.1159/000541585

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  • Other electrolyte abnormalities may occur in THPP due to transcellular shifts.

    “Other electrolyte abnormalities may occur due to transcellular shifts [1].”

    From Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms (2025) · cites this paper as [1]

    The Discussion (page not available) says intracellular potassium shifts cause hypokalemia in thyrotoxic periodic paralysis. It does not say that other electrolyte abnormalities occur because of transcellular shifts. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Some studies have reported a prevalence of HPP as high as 10% among thyrotoxic patients.

    “Some studies have reported a prevalence of HPP as high as 10% among thyrotoxic patients [1].”

    From Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms (2025) · cites this paper as [1]

    The Discussion states that up to 10% of thyrotoxic patients may experience periodic paralysis, but places that figure in the context of Asian or Hispanic males, in whom the condition is more common. The citing sentence omits that population qualification. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 1

  1. [14]Manoukian MA, Foote JA, Crapo LM. Clinical and metabolic features of thyrotoxic periodic paralysis in 24 episodes. Arch Intern Med. 1999; 159(6): 601– 6. 10090117

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Authors
Al Hariri, B., Hassan, M. A., Sharif, M., Alsakaji, O. A., Hassan, Y. A., & Khalid, M. K.
Affiliations
  • Sidra Medical and Research Center (QA)
  • Hamad Medical Corporation (QA)
  • Weill Cornell Medical College in Qatar (QA)
Corresponding author
  • Hassan, Muad Abdi
  • Hassan, Yussuf Abdi
ORCID
Venue
Case Reports in Neurology
Publisher
S. Karger AG
Published
2024-10-02
Volume
16
Issue
1
Pages
274-280
ISSN
1662-680X (ISSN-L)
DOI
10.1159/000541585
PMC
PMC11501104
OpenAlex
W4403063040
Cited by
8
References
19
Citations by year
2026: 5 · 2025: 3
FWCI
2.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Case Reports in Neurology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
periodic paralysis, hypokalemic periodic paralysis, thyrotoxic periodic paralysis, flaccid paralysis, muscle weakness, thyrotoxicosis, autosomal dominant inheritance, differential diagnosis

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