Thyrotoxic Hypokalemic Periodic Paralysis: Report of Four Cases in Black American Males1
Abstract
Thyrotoxic periodic paralysis (TPP) is an unusual complication of a fairly common disease affecting mostly Asian males. In the United States, there have been several reports of TPP in different ethnic populations and it appears that the incidence is approximately one-tenth of that found in Asian countries. Only six reports of TPP in African-Americans could be found in the literature; however, we are reporting four cases diagnosed within a 13-year period at our institution. We conclude that TPP may occur more often in Blacks than previously suspected and should be considered when patients present with unexplained hypokalemia, muscular weakness and rhabdomyolysis. The epidemiology, clinical manifestations, pathophysiology, and treatment of TPP are reviewed.
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- Authors
- Kilpatrick, R. E., Seiler-Smith, S., & Levine, S. N.
- Affiliations
- Louisiana State University (US)
- ORCID
- Levine, Steven N.
- Venue
- Thyroid®
- Publisher
- SAGE Publications
- Published
- 1994-12
- Volume
- 4
- Issue
- 4
- Pages
- 441-445
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2048325493
- Cited by
- 41
- References
- 26
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 3
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyrotoxic periodic paralysis, hypokalemia, hyperthyroidism, African American patients, rhabdomyolysis, muscle weakness, ethnic prevalence, pathophysiology, treatment
- MeSH terms
- Adult, Black or African American, Humans, Hypokalemia, Male, Middle Aged, Paralyses, Familial Periodic, Thyrotoxicosis, Black People
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