The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets
Abstract
Summary: Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by theirability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development of thrombotic complications in the pathologic states associated with the increase of their blood concentration. In this study we compared procoagulant properties of calcium ionophore A23187-activated platelets and PMPs using several in-vitro models of hemostasis. Surface densities of phosphatidylserine, CD61, CD62P and factor X bound per surface area unit were determined by flow cytometry. They were 2.7-, 8.4-, 4.3-, and 13-fold higher for PMPs than for activated platelets, respectively. Spatial clot growth rate (Vclot) in the reaction-diffus ion experimental model and endogenous thrombin potential (ETP) were determined in plasma, which was depleted of phospholipid cell surfaces by ultra-centrifugation and supplemented with activated platelets or PMPs at different concentrations. Both Vcllot and ETP rapidly increased with the increase of PMP or platelet concentration until saturation was reached. The plateau values of Vclot and ETP for activated platelets and PMPs were similar. In both assays, the procoagulant activity of one PMP was almost equal to that of one activated platelet despite at least two-orders-of-magnitude difference in their surface areas. This suggests that the PMP surface is approximately 50- to 100-fold more procoagulant than the surface of activated platelets.
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Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation
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Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
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Cited by
Microparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange
Mause, S. F., & Weber, C. (2010) · Circulation Research · doi:10.1161/circresaha.110.226456 · Cited by 786
Molecular interactions at the surface of extracellular vesicles
Buzás, E. I., Tóth, E. Á., Sódar, B. W., & Szabó-Taylor, K. É. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0682-0 · Cited by 375
Hemeda, H., Giebel, B., & Wagner, W. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2013.11.004 · Cited by 310
Rak, J. (2010) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0030-1267043 · Cited by 301
Biomarkers for prediction of venous thromboembolism in cancer
Pabinger, I., Thaler, J., & Ay, C. (2013) · Blood · doi:10.1182/blood-2013-04-460147 · Cited by 256
Metadata
- Authors
- Kireev, D., Popenko, N., Pichugin, A., Panteleev, M., Krymskaya, O., Ataullakhanov, F., & Sinauridze, E.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2007
- Volume
- 97
- Issue
- 03
- Pages
- 425-434
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2168183582
- Cited by
- 553
- References
- 23
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kireev, D., Popenko, N., Pichugin, A., Panteleev, M., Krymskaya, O., Ataullakhanov, F., & Sinauridze, E. (2007). Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thrombosis and Haemostasis. https://doi.org/10.1160/th06-06-0313
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
