The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Prospective validation of the Pulmonary Embolism Severity Index: A clinical prognostic model for pulmonary embolism
Abstract
Summary: Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified. Using data from U.S. patients, we previously derived the Pulmonary Embolism Severity Index (PESI), a prediction rule that risk stratifies patients with PE. We sought to validate the PESI in a European patient cohort. We prospectively validated the PESI in patients with PE diagnosed at six emergency departments in three European countries. We used baseline data for the rule’s 11 prognostic variables to stratify patients into five risk classes (I-V) of increasing probability of mortality. The outcome was overall mortality at 90 days after presentation.To assess the accuracy of the PESI to predict mortality, we estimated the sensitivity, specificity, and predictive values for low- (risk classes I/II) versus higher- risk patients (risk classes III-V), and the discriminatory power using the area under the receiver operating characteristic (ROC) curve. Among 357 patients with PE, overall mortality was 5.9%, ranging from 0% in class I to 17.9% in class V. The 186 (52%) low-risk patients had an overall mortality of 1.1% (95% confidence interval [CI]: 0.1–3.8%) compared to 11.1% (95% CI: 6.8–16.8%) in the 171 (48%) higher- risk patients. The PESI had a high sensitivity (91%,95% CI: 71–97%) and a negative predictive value (99%, 95% CI: 96–100%) for predicting mortality. The area under the ROC curve was 0.78 (95% CI:0.70–0.86). The PESI reliably identifies patients with PE who are at low risk of death and who are potential candidates for outpatient care. The PESI may help physicians make more rational decisions about hospitalization for patients with PE.
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Cites
A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia
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Self-citationDerivation and validation of a prognostic model for pulmonary embolism
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Self-citationAssessing the Generalizability of Prognostic Information
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Users' Guides to the Medical Literature: XXII: How to Use Articles About Clinical Decision Rules
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Self-citationPredicting Adverse Outcome in Patients with Acute Pulmonary Embolism: A Risk Score
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Self-citationten Wolde, M., Söhne, M., Quak, E., Mac Gillavry, M. R., & Büller, H. R. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.15.1685 · Cited by 313
Cited by
Konstantinides, S. V., Meyer, G., Becattini, C., Bueno, H., Geersing, G.-J., Harjola, V.-P., Huisman, M. V., Humbert, M., Jennings, C. S., Jiménez, D., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz405 · Cited by 4,916
Self-citation2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu283 · Cited by 3,128
Self-citationKonstantinides, S. V., Meyer, G., Becattini, C., Bueno, H., Geersing, G.-J., Harjola, V.-P., Huisman, M. V., Humbert, M., Jennings, C. S., Jiménez, D., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.01647-2019 · Cited by 1,619
Self-citationJiménez, D. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.199 · Cited by 1,354
Barco, S., Mahmoudpour, S. H., Planquette, B., Sanchez, O., Konstantinides, S. V., & Meyer, G. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy873 · Cited by 313
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Metadata
- Authors
- Gal, G., Fine, M. J., Roy, P.-M., Sanchez, O., Verschuren, F., Cornuz, J., Meyer, G., Perrier, A., Righini, M., Aujesky, D., & Donzé, J.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2008
- Volume
- 100
- Issue
- 05
- Pages
- 943-948
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2083225817
- Cited by
- 358
- References
- 30
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gal, G., Fine, M. J., Roy, P.-M., Sanchez, O., Verschuren, F., Cornuz, J., Meyer, G., Perrier, A., Righini, M., Aujesky, D., & Donzé, J. (2008). Prospective validation of the Pulmonary Embolism Severity Index: A clinical prognostic model for pulmonary embolism. Thrombosis and Haemostasis. https://doi.org/10.1160/th08-05-0285
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