The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability
Open accessAbstract
Objective— Oxidation of LDL plays a significant pathogenic role in atherosclerosis. In this study, we attempted to clarify the correlation between the morphology of human atherosclerotic plaques and the oxidized LDL (OxLDL) levels in plasma and carotid plaques. Methods and Results— OxLDL levels (ng/μg apolipoprotein B) in plasma and carotid plaques from 44 patients undergoing carotid endarterectomy and OxLDL levels in 17 control plasma and 9 normal intima samples were determined by a sandwich ELISA by using specific antibodies against OxLDL (DLH3) and apolipoprotein B. The plaques were immunohistochemically classified as macrophage (Mφ)-rich and Mφ-poor. In paired samples from individual patients, plaque OxLDL was nearly 70 times higher than plasma OxLDL (mean±SEM, 11.9±1.7 vs 0.18±0.01 ng/μg apoB, P <0.0001). The OxLDL level was significantly higher in Mφ-rich- than Mφ-poor plaques (19.6±2.8 vs 5.50±0.77ng/μg apoB, P <0.0001) and corresponded with DLH3 antigen positivity of the plaques. In patients with Mφ-rich plaques, plasma OxLDL was significantly higher than in the controls (0.20±0.02 vs 0.13±0.01ng/μg apoB, P =0.02). Conclusions— Our results suggest that LDL undergoes further oxidation in plaques, and that high plasma and plaque levels of OxLDL are correlated with the vulnerability to rupture of atherosclerotic lesions.
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Cites
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Cited by
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
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How Do Elevated Triglycerides and Low HDL-Cholesterol Affect Inflammation and Atherothrombosis?
Welty, F. K. (2013) · Current Cardiology Reports · doi:10.1007/s11886-013-0400-4 · Cited by 221
Metadata
- Authors
- Nishi, K., Itabe, H., Uno, M., Kitazato, K. T., Horiguchi, H., Shinno, K., & Nagahiro, S.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2002-10
- Volume
- 22
- Issue
- 10
- Pages
- 1649-1654
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2150031599
- Cited by
- 409
- References
- 21
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nishi, K., Itabe, H., Uno, M., Kitazato, K. T., Horiguchi, H., Shinno, K., & Nagahiro, S. (2002). Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000033829.14012.18
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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