Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population
Abstract
BACKGROUND: Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall. METHODS AND RESULTS: In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalent CHD or diabetes mellitus at baseline. Subjects came from 2 population-based MONICA/KORA Augsburg surveys conducted in the years 1989-1990 and 1994-1995 with follow-up in 1998 (mean+/-SD follow-up time, 5.6+/-2.6 years). OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls. Hazard ratios (HRs) were estimated from conditional logistic-regression models with matching for age and survey. Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls (mean+/-SD, 110+/-32 versus 93+/-28 U/L; P< or =0.001). After adjustment for smoking, hypertension, obesity, physical activity, education, and alcohol consumption, the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 (95% confidence interval, 2.09 to 8.63; P<0.001). Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD. When both oxLDL and C-reactive protein were simultaneously assessed in the same model, they still predicted future CHD events even after multivariable adjustment. CONCLUSIONS: Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men. Thus, oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies.
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Plasma levels of oxidized LDL predict acute coronary heart disease in relatively healthy individuals and in patients with coronary heart disease, and is a prognostic marker for subclinical atherosclerosis.
“Plasma levels of oxidized LDL predict acute coronary heart disease in relatively healthy individuals and in patients with coronary heart disease, and is a prognostic marker for subclinical atherosclerosis (47).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [47]
Oxidized LDL particles might play a role in atherosclerosis onset and progression by inducing endothelial dysfunction and macrophage transformation into foam cells.
“In this regard, it has been highlighted that oxidized LDL particles might play a role in atherosclerosis onset and progression, given their ability to induce endothelial dysfunction and macrophagic transformation into foam cells, following phagocytosis of LDLs [204,205].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [205]
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Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649 · see citing works
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Model Selection and Inference: A Practical Information-Theoretic Approach
Strawderman, R. L., Burnham, K. P., & Anderson, D. R. (2000) · Journal of the American Statistical Association · doi:10.2307/2669574 · Cited by 4,194 · see citing works
Role of oxidized low density lipoprotein in atherogenesis.
Witztum, J. L., & Steinberg, D. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115499 · Cited by 2,682 · see citing works
Information theory as an extension of the maximum likelihood principle
Akaike, H. (1973) · Medical Entomology and Zoology · Cited by 2,357 · see citing works
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952 · see citing works
van der Wal, A. C., Becker, A. E., van der Loos, C. M., & Das, P. K. (1994) · Circulation · doi:10.1161/01.cir.89.1.36 · Cited by 1,906 · see citing works
WHO MONICA Project Principal Invest (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90084-4 · Cited by 1,798 · see citing works
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,726 · see citing works
Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511 · see citing works
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Salonen, J. T., Korpela, H., Salonen, R., Nyyssönen, K., Ylä‐Herttuala, S., Yamamoto, R., Butler, S., Palinski, W., & Witztum, J. L. (1992) · The Lancet · doi:10.1016/0140-6736(92)90926-t · Cited by 1,311 · see citing works
Kornitzer, M., Berghmans, L., Wilmet, M. D., Darquennes, H., Lagasse, R., & Payen, R. (1988) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 1,270 · see citing works
Antioxidant defenses and lipid peroxidation in human blood plasma.
Frei, B. B., Stocker, R., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9748 · Cited by 1,254 · see citing works
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.
Stemme, S., Faber, B., Holm, J., Wiklund, O., Witztum, J. L., & Hansson, G. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3893 · Cited by 943 · see citing works
Practical Use of the Information-Theoretic Approach
Burnham, K. P., & Anderson, D. R. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2917-7_3 · Cited by 790 · see citing works
Ehara, S., Ueda, M., Naruko, T., Haze, K., Itoh, A., Otsuka, M., Komatsu, R., Matsuo, T., Itabe, H., Takano, T., et al. (2001) · Circulation · doi:10.1161/01.cir.103.15.1955 · Cited by 780 · see citing works
Lewis A. Conner Memorial Lecture
Steinberg, D. H. (1997) · Circulation · doi:10.1161/01.cir.95.4.1062 · Cited by 743 · see citing works
New Markers of Inflammation and Endothelial Cell Activation: Part I
Szmitko, P. E., Wang, C.-H., Weisel, R. D., de Almeida, J. R., Anderson, T. J., & Verma, S. (2003) · Circulation · doi:10.1161/01.cir.0000089190.95415.9f · Cited by 738 · see citing works
Holvoet, P., Vanhaecke, J., Janssens, S., de Werf, F. V., & Collen, D. (1998) · Circulation · doi:10.1161/01.cir.98.15.1487 · Cited by 673 · see citing works
Palinski, W., Miller, E. R., & Witztum, J. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.821 · Cited by 591 · see citing works
C-Reactive Protein: Risk Marker or Mediator in Atherothrombosis?
Jialal, I., Devaraj, S., & Venugopal, S. K. (2004) · Hypertension · doi:10.1161/01.hyp.0000130484.20501.df · Cited by 569 · see citing works
Circulating Oxidized LDL Is a Useful Marker for Identifying Patients With Coronary Artery Disease
Holvoet, P., Mertens, A. C., Verhamme, P. B., Bogaerts, K., Beyens, G., Verhaeghe, R., Collen, D., Muls, E., & de Werf, F. V. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.844 · Cited by 530 · see citing works
Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability
Nishi, K., Itabe, H., Uno, M., Kitazato, K. T., Horiguchi, H., Shinno, K., & Nagahiro, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000033829.14012.18 · Cited by 409 · see citing works
Circulating Oxidized Low Density Lipoprotein Levels
Toshima, S., Hasegawa, A., Kurabayashi, M., Itabe, H., Takano, T., Sugano, J., SHIMAMURA, K., Kimura, J., Michishita, I., Suzuki, T., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2243 · Cited by 408 · see citing works
Ameli, S., Hultgårdh‐Nilsson, A., Regnström, J., Calara, F. B., Yano, J., Cercek, B., Shah, P. K., & Nilsson, J. Å. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.1074 · Cited by 355 · see citing works
New Risk Factors for Atherosclerosis and Patient Risk Assessment
Fruchart, J., Nierman, M. C., Stroes, E. S. G., Kastelein, J. J. P., & Duriez, P. (2004) · Circulation · doi:10.1161/01.cir.0000131513.33892.5b · Cited by 348 · see citing works
Holvoet, P., Kritchevsky, S. B., Tracy, R. P., Mertens, A. C., Rubin, S. M., Butler, J., Goodpaster, B. H., & Harris, T. B. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1068 · Cited by 318 · see citing works
Freigang, S., Hörkkö, S., Miller, E. R., Witztum, J. L., & Palinski, W. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.12.1972 · Cited by 315 · see citing works
Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice.
Nicoletti, A., Kaveri, S. V., Caligiuri, G., Bariety, J., & Hansson, G. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119892 · Cited by 302 · see citing works
Xu, X., Meisel, S. R., Ong, J. M., Kaul, S., Cercek, B., Rajavashisth, T. B., Sharifi, B. G., & Shah, P. K. (1999) · Circulation · doi:10.1161/01.cir.99.8.993 · Cited by 299 · see citing works
Hutchinson, W. L., Köenig, W., Fröhlich, M., Sund, M., Lowe, G. D. O., & Pepys, M. B. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.7.934 · Cited by 250 · see citing works
Induction of T-cell activation by oxidized low density lipoprotein.
Frostegård, J., Wu, R., Giscombe, R., Holm, G., Lefvert, A., & Nilsson, J. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.4.461 · Cited by 243 · see citing works
Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S., & Mehta, J. L. (2003) · Circulation · doi:10.1161/01.cir.0000047276.52039.fb · Cited by 218 · see citing works
Oxidized Low Density Lipoproteins in Patients With Transplant-Associated Coronary Artery Disease
Holvoet, P., Stassen, J., Cleemput, J. V., Collen, D., & Vanhaecke, J. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.100 · Cited by 177 · see citing works
Li, D., Liu, L., Chen, H., Sawamura, T., & Mehta, J. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000066685.13434.fa · Cited by 149 · see citing works
WHO MONICA Project: Objectives and Design
WHO MONICA Project (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.3_supplement_1.s29 · Cited by 133 · see citing works
Oxidized LDL Stimulates Matrix Metalloproteinase-1 Expression in Human Vascular Endothelial Cells
Huang, Y. Q., Mironova, M., & Lopes-Virella, M. F. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2640 · Cited by 114 · see citing works
Essential familial hypercholesterolemia and xanthomatosis
Piper, J., & Orrild, L. (1956) · The American Journal of Medicine · doi:10.1016/0002-9343(56)90006-7 · Cited by 102 · see citing works
Köenig, W., Sund, M., Do¨ring, A., & Ernst, E. (1997) · Circulation · doi:10.1161/01.cir.95.2.335 · Cited by 93 · see citing works
WHO MONICA Project: Objectives and Design
WHO MONICA Project (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.supplement_1.s29 · Cited by 93 · see citing works
Pai, J. K., Curhan, G. C., Cannuscio, C. C., Rifai, N., Ridker, P. M., & Rimm, E. B. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.10.1781 · Cited by 86 · see citing works
LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation
Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T., & Mehta, J. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00382.2002 · Cited by 82 · see citing works
PepT1-mediated fMLP transport induces intestinal inflammation in vivo
Buyse, M., Tsocas, A., Walker, F., Merlin, D., & Bado, A. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00186.2002 · Cited by 76 · see citing works
Plasma oxidized LDL: a predictor for acute myocardial infarction?
Fredrikson, G. N., Hedblad, B., Berglund, G., & Nilsson, J. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01128.x · Cited by 64 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Piper J, Orrild L. Essential familial hypercholesterolaemia and xantho- matosis: follow-up study of twelve Danish families. Am J Med. 1956;21: 34 -46.
- Hense HW, Filipiak B, Doering A, Stieber J, Liese A, Keil U. Ten-year trends of cardiovascular risk factors in the MONICA Augsburg region in southern Germany: results from 1984/1985, 1989/1990, and 1994/1995 surveys. CVD Prev. 1998;1:318 -327.
Cited by
Sorted by citations
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Vasan, R. S. (2006) · Circulation · doi:10.1161/circulationaha.104.482570 · Cited by 1,212 · see citing works
Biological markers of oxidative stress: Applications to cardiovascular research and practice
Ho, E. C., Galougahi, K. K., Liu, C., Bhindi, R., & Figtree, G. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.006 · Cited by 812 · see citing works
Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769 · see citing works
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors: A Randomized Trial
Covas, M.-I., Nyyssönen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H.-J. F., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Bäumler, H., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-5-200609050-00006 · Cited by 758 · see citing works
Kontush, A., & Chapman, M. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.1 · Cited by 752 · see citing works
Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation: A Randomized Controlled Trial
Fitó, M., Guxens, M., Corella, D., Sáez, G., Estruch, R., de la Torre, R., Francés, F., Cabezas, C., López-Sabater, M. D. C., Marrugat, J., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1195 · Cited by 448 · see citing works
Biomarkers of Atherosclerotic Plaque Instability and Rupture
Köenig, W., & Khuseyinova, N. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251503.35795.4f · Cited by 417 · see citing works
Self-citationReactive Oxygen Species: A Key Hallmark of Cardiovascular Disease
Panth, N., Paudel, K. R., & Parajuli, K. (2016) · Advances in Medicine · doi:10.1155/2016/9152732 · Cited by 405 · see citing works
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 401 · see citing works
Antioxidants, inflammation and cardiovascular disease
Mangge, H. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.462 · Cited by 339 · see citing works
Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases
Trpković, A., Resanović, I., Stanimirović, J., Radak, D. J., Mousa, S. A., Cenic-Milosevic, D., Jevremović, D., & Isenović, E. R. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.992063 · Cited by 322 · see citing works
Lekakis, J. P., Abraham, P., Balbarini, A., Blann, A. D., Boulanger, C. M., Cockcroft, J., Cosentino, F., Deanfield, J. E., Gallino, A., Ikonomidis, I., et al. (2011) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/1741826711398179 · Cited by 313 · see citing works
Assessing the Role of Circulating, Genetic, and Imaging Biomarkers in Cardiovascular Risk Prediction
Wang, T. J. (2011) · Circulation · doi:10.1161/circulationaha.109.912568 · Cited by 295 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“In this regard, it has been highlighted that oxidized LDL particles might play a role in atherosclerosis onset and progression, given their ability to induce endothelial dysfunction and macrophagic transformation into foam cells, following phagocytosis of LDLs [204,205].”
BackgroundMetabolic and Vascular Effect of the Mediterranean Diet
Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., & Pinto, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194716 · Cited by 269 · see citing works
Stephens, J. W., Khanolkar, M., & Bain, S. C. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.06.006 · Cited by 262 · see citing works
López‐García, E., van Dam, R. M., Qi, L., & Hu, F. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.888 · Cited by 257 · see citing works
Kiechl, S. J., Willeit, J., Mayr, M., Viehweider, B., Oberhollenzer, M., Kronenberg, F., Wiedermann, C. J., Oberthaler, S., Xu, Q., Witztum, J. L., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145805 · Cited by 249 · see citing works
Detection of High-Risk Atherosclerotic Plaque
Fleg, J. L., Stone, G. W., Fayad, Z. A., Granada, J. F., Hatsukami, T. S., Kolodgie, F. D., Jacques Ohayon, A., Pettigrew, R. I., Sabatine, M. S., Tearney, G. J., et al. (2012) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2012.07.007 · Cited by 235 · see citing works
Lee, R., Margaritis, M., Channon, K. M., & Antoniades, C. A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800493057 · Cited by 228 · see citing works
Extra virgin olive oil: More than a healthy fat
Yubero‐Serrano, E. M., López-Moreno, J., Gómez-Delgado, F., & López‐Miranda, J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0304-x · Cited by 226 · see citing works
The Relationship of Coffee Consumption with Mortality
López‐García, E., van Dam, R. M., Li, T. Y., Rodriguez-Artalejo, F., & Hu, F. B. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-12-200806170-00003 · Cited by 201 · see citing works
Hutcheson, R., & Ročić, P. (2012) · Experimental Diabetes Research · doi:10.1155/2012/271028 · Cited by 200 · see citing works
Castilla, P., Dávalos, A., Teruel, J. L., Cerrato, F., Fernández‐Lucas, M., Merino, J. L., Sánchez-Martín, C. C., Ortuño, J. Á., & Lasunción, M. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1053 · Cited by 194 · see citing works
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
Postprandial metabolic events and fruit-derived phenolics: a review of the science
Burton‐Freeman, B. M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003909 · Cited by 185 · see citing works
Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease.
Holvoet, P. (2008) · PubMed · Cited by 185 · see citing works
de la Torre‐Carbot, K., Jáuregui, O., Gimeno, E., Castellote, A. I., Lamuela-Raventós, R. M., & López‐Sabater, M. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0501948 · Cited by 182 · see citing works
Air pollution and circulating biomarkers of oxidative stress
Delfino, R. J., Staimer, N., & Vaziri, N. D. (2011) · Air Quality, Atmosphere & Health · doi:10.1007/s11869-010-0095-2 · Cited by 181 · see citing works
Awasthi, D., Nagarkoti, S., Kumar, A., Dubey, M., Singh, A. K., Pathak, P., Chandra, T., Barthwal, M. K., & Dikshit, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.004 · Cited by 179 · see citing works
Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations
Noels, H., Lehrke, M., Vanholder, R. C., & Jankowski, J. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00423-5 · Cited by 183 · see citing works
Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing
Grădinaru, D., Borșa, C., Ionescu, C., & Prada, G. I. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.003 · Cited by 174 · see citing works
Effects of dietary factors on oxidation of low-density lipoprotein particles
Lapointe, A., Couillard, C., & Lemieux, S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.01.001 · Cited by 169 · see citing works
Gaggini, M., Gorini, F., & Vassalle, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010075 · Cited by 183 · see citing works
Hermsdorff, H. H. M., Puchau, B., Volp, A. C. P., Barbosa, K. B., Bressan, J., Zulet, M. Á., & Martínez, J. A. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-59 · Cited by 163 · see citing works
Carbamylated low-density lipoprotein induces endothelial dysfunction
Speer, T., Owala, F. O., Holy, E. W., Zewinger, S., Frenzel, F., Stähli, B. E., Razavi, M., Triem, S., Cvija, H., Rohrer, L., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu111 · Cited by 161 · see citing works
Circulating oxidized LDL: a biomarker and a pathogenic factor
Ishigaki, Y., Oka, Y., & Katagiri, H. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832fa58d · Cited by 162 · see citing works
NLRP3 inflammasome activation in inflammaging
Latz, E., & Duewell, P. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.001 · Cited by 174 · see citing works
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158 · see citing works
Fraley, A. E., & Tsimikas, S. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000245255.40634.b5 · Cited by 153 · see citing works
Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases
Gianazza, E., Brioschi, M., Fernandez, A. M., Casalnuovo, F., Altomare, A., Aldini, G., & Banfi, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7955 · Cited by 158 · see citing works
Estruch, R., Sacanella, E., Mota, F. R., Chiva‐Blanch, G., Antúnez, E., Casals, E., Deulofeu, R., Rotilio, D., Andrés‐Lacueva, C., & Lamuela-Raventós, R. M. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.07.006 · Cited by 152 · see citing works
Gao, S., Zhao, D. H., Wang, M., Zhao, F., Han, X., Qi, Y., & Liu, J. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.07.015 · Cited by 151 · see citing works
Holvoet, P., Jenny, N. S., Schreiner, P. J., Tracy, R. P., & Jacobs, D. R. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.002 · Cited by 149 · see citing works
Sánchez‐Quesada, C., López-Biedma, A., Warleta, F., Campos, M., Beltrán, G., & Gaforio, J. J. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403154e · Cited by 147 · see citing works
Measurement of Plasma Oxidized Low-Density Lipoprotein and its Clinical Implications
Itabe, H., & Ueda, M. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14.1 · Cited by 147 · see citing works
Oxidative stress biomarkers as predictors of cardiovascular disease
Strobel, N., Fassett, R. G., Marsh, S. A., & Coombes, J. S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.008 · Cited by 145 · see citing works
Olive oil and oxidative stress
Fitó, M., de la Torre, R., & Covas, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600308 · Cited by 143 · see citing works
Atherogenic dyslipidemia and oxidative stress: a new look
Rizzo, M., Kotur‐Stevuljević, J., Berneis, K. K., Spinas, G. A., Rini, G. B., Jelić‐Ivanović, Z., Spasojević‐Kalimanovska, V., & Vekić, J. (2009) · Translational research · doi:10.1016/j.trsl.2009.01.008 · Cited by 142 · see citing works
Bays, H. E., Ballantyne, C. M., Braeckman, R. A., Stirtan, W. G., & Soni, P. N. (2013) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-012-0002-3 · Cited by 141 · see citing works
Khan, N., Monagas, M., Andrés‐Lacueva, C., Casas, R. M., Urpí-Sardà, M., Lamuela-Raventós, R. M., & Estruch, R. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.02.001 · Cited by 138 · see citing works
Gao, S., & Liu, J. (2017) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2017.02.008 · Cited by 136 · see citing works
Meisinger, C., Döring, A., Schneider, A. L. C., & Löwel, H. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.01.010 · Cited by 135 · see citing works
Self-citationde la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Nurmi, T., Poulsen, H. E., Gaddi, A. V., Kaikkonen, J., Zunft, H.-F., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.112912 · Cited by 132 · see citing works
Elkan, A., Sjöberg, B. G., Kolsrud, B., Ringertz, B., Hafström, I., & Frostegård, J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2388 · Cited by 129 · see citing works
Oxidized LDL and the metabolic syndrome
Holvoet, P., Keyzer, D. D., & Jacobs, D. R. (2008) · Future Lipidology · doi:10.2217/17460875.3.6.637 · Cited by 129 · see citing works
Hansel, B., Nicolle, C., Lalanne, F., Tondu, F., Lassel, T. S., Donazzolo, Y., Ferrières, J., Krempf, M., Schlienger, J.-L., Vergès, B. L., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.790 · Cited by 125 · see citing works
Côté, C., Pibarot, P., Després, J.-P., Mohty, D., Cartier, A., Arsenault, B. J., Couture, C., & Mathieu, P. (2008) · Heart · doi:10.1136/hrt.2007.125740 · Cited by 121 · see citing works
Antioxidant Activity of Olive Polyphenols in Humans: a Review
Raederstorff, D. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.3.152 · Cited by 122 · see citing works
Verhoye, E., & Langlois, M. R. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2009.037 · Cited by 120 · see citing works
Carotid plaque formation and serum biomarkers
Hermus, L., Lefrandt, J. D., Tio, R. A., Breek, J. C., & Zeebregts, C. J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.013 · Cited by 116 · see citing works
The effects of low-carbohydrate diets on cardiovascular risk factors: A meta-analysis
Dong, T., Guo, M., Zhang, P., Sun, G., & Chen, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0225348 · Cited by 113 · see citing works
Tang, F., Wu, X., Wang, T., Wang, P., Li, R., Zhang, H., Gao, J., Chen, S., Bao, L., Huang, H., et al. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.01.001 · Cited by 111 · see citing works
Gjuladin-Hellon, T., Davies, I. G., Penson, P., & Amiri Baghbadorani, R. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy049 · Cited by 108 · see citing works
Pistachios Increase Serum Antioxidants and Lower Serum Oxidized-LDL in Hypercholesterolemic Adults
Kay, C. D., Gebauer, S. K., West, S. G., & Kris‐Etherton, P. M. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117366 · Cited by 107 · see citing works
Narverud, I., Retterstøl, K., Iversen, P. O., Halvorsen, B. L., Ueland, T., Ulven, S. M., Ose, L., Aukrust, P., Veierød, M. B., & Holven, K. B. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.917 · Cited by 106 · see citing works
Valls, R. M., Farràs, M., Suárez, M., Fernández‐Castillejo, S., Fitó, M., Konstantinidou, V., Fuentes, F. J., López‐Miranda, J., Giralt, M., Covas, M., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.107 · Cited by 106 · see citing works
Solà, R., Bruckert, É., Valls, R. M., Narejos, S., Luque, X., Cabezas, M. C., Doménech, G., Torres, F., Heras, M., Farrés, X., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.03.010 · Cited by 105 · see citing works
Chatterjee, S. B., Balram, A., & Li, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041816 · Cited by 102 · see citing works
Hermsdorff, H. H. M., Barbosa, K. B. F., Volp, A. C. P., Puchau, B., Bressan, J., Zulet, M. Á., & Martínez, J. A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004235 · Cited by 97 · see citing works
Kostyuk, V. A., Potapovich, A. I., Suhan, T. O., Luca, C. D., & Korkina, L. G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.02.022 · Cited by 94 · see citing works
Increased Cellular and Circulating Biomarkers of Oxidative Stress in Nascent Metabolic Syndrome
Jialal, I., Devaraj, S., ADAMS-HUET, B. A., Chen, X., & Kaur, H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2498 · Cited by 94 · see citing works
Serra, T., Rocha, J. P., Sepodes, B. M. N., Matias, A. A., Feliciano, R. P., de Carvalho, A., Bronze, M. R., Duarte, C. M. M., & Figueira, M. E. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.07.067 · Cited by 90 · see citing works
Extra Virgin Olive Oil: Lesson from Nutrigenomics
Santis, S. D., Cariello, M., Piccinin, E., Sabbà, C., & Moschetta, A. (2019) · Nutrients · doi:10.3390/nu11092085 · Cited by 89 · see citing works
Oxidized low-density lipoprotein biomarkers in atherosclerosis
Tsimikas, S. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0065-1 · Cited by 88 · see citing works
Satoh, N., Shimatsu, A., Kotani, K., Himeno, A., Majima, T., Yamada, K., Suganami, T., & Ogawa, Y. (2009) · Hypertension Research · doi:10.1038/hr.2009.145 · Cited by 85 · see citing works
Wu, T., Willett, W. C., Rifai, N., Shai, I., Manson, J. E., & Rimm, E. B. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.057 · Cited by 85 · see citing works
Vuilleumier, N., Rossier, M. F., Pagano, S., Python, M., Charbonney, E., Nkoulou, R. N., James, R., Reber, G., Mach, F., & Roux-Lombard, P. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq055 · Cited by 86 · see citing works
Plasma Oxidized Low-Density Lipoprotein Levels and Arterial Stiffness in Older Adults
Brinkley, T. E., Nicklas, B. J., Kanaya, A. M., Satterfield, S., Lakatta, E. G., Simonsick, E. M., Sutton‐Tyrrell, K., & Kritchevsky, S. B. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127043 · Cited by 85 · see citing works
Skibska, B., & Gorąca, A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/313021 · Cited by 83 · see citing works
Nakhjavani, M., Khalilzadeh, O., Khajeali, L., Esteghamati, A., Morteza, A., Jamali, A., & Dadkhahipour, S. (2010) · Lipids · doi:10.1007/s11745-010-3401-8 · Cited by 83 · see citing works
Hong, C. G., Florida, E. M., Li, H., Parel, P. M., Mehta, N. N., & Sorokin, A. V. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1023651 · Cited by 82 · see citing works
Nestel, P. J., Mellett, N., Pally, S., Wong, G., Barlow, C. K., Croft, K., Mori, T. A., & Meikle, P. J. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001621 · Cited by 81 · see citing works
Atherogenecity of LDL and Unfavorable Adipokine Profile in Metabolically Obese, Normal‐weight Woman
Hyun, Y. J., Koh, S. J., Chae, J., Kim, J. Y., Kim, O. Y., Lim, H. H., Jang, Y., Park, S., Ordovás, J. M., & Lee, J. H. (2008) · Obesity · doi:10.1038/oby.2007.127 · Cited by 81 · see citing works
Calò, L., Naso, A., Carraro, G., Wratten, M. L., Pagnin, E., Bertipaglia, L., Rebeschini, M., Davis, P. A., Piccoli, A., & Cascone, C. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl783 · Cited by 81 · see citing works
Tang, F., Chen, S. R., Wu, X., Wang, T. Q., Chen, J. W., Li, J., Bao, L. P., Huang, H., & Liu, P. Q. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0004-8 · Cited by 80 · see citing works
Holvoet, P., Macy, E., Landeloos, M., Jones, D., Nancy, J. S., de Werf, F. V., & Tracy, R. P. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.064337 · Cited by 80 · see citing works
Oxidized LDL and the Risk of Coronary Heart Disease: Results from the MONICA/KORA Augsburg Study
Köenig, W., Karakas, M., Zierer, A., Herder, C., Baumert, J. J., Meisinger, C., & Thorand, B. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.165134 · Cited by 80 · see citing works
Self-citationKarakas, M., Köenig, W., Zierer, A., Herder, C., Rottbauer, W., Baumert, J. J., Meisinger, C., & Thorand, B. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02397.x · Cited by 78 · see citing works
Self-citationGimeno, E., de la Torre‐Carbot, K., Lamuela-Raventós, R. M., Castellote, A. I., Fitó, M., de la Torre, R., Covas, M., & López‐Sabater, M. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507778698 · Cited by 76 · see citing works
Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half Century
Guyenet, S. J., & Carlson, S. E. (2015) · Advances in Nutrition · doi:10.3945/an.115.009944 · Cited by 74 · see citing works
Ferk, F., Kundi, M., Brath, H., Szekeres, T., Al-Serori, H., Mišík, M., Saiko, P., Marculescu, R., Wagner, K., & Knasmüller, S. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700482 · Cited by 73 · see citing works
Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis
Sorokin, A. V., Kotani, K., Elnabawi, Y. A., Dey, A. K., Sajja, A. P., Yamada, S., Ueda, M., Harrington, C. L., Baumer, Y., Rodante, J. A., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313608 · Cited by 73 · see citing works
The GAIT translational control system
Arif, A., Yao, P., Terenzi, F., Jia, J., Ray, P. S., & Fox, P. L. (2017) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1441 · Cited by 71 · see citing works
Yıldız, G., Duman, A., Aydın, H., Yılmaz, A., Hür, E., Mağden, K., Çetin, G., & Candan, F. (2013) · Hemodialysis International · doi:10.1111/hdi.12041 · Cited by 68 · see citing works
Chen, W., Tang, F., Xie, B., Chen, S., Huang, H., & Liu, P. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.10.040 · Cited by 69 · see citing works
Steffen, Y., Jung, T., Klotz, L., SCHEWE, T., Grune, T., & Sies, H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.024 · Cited by 68 · see citing works
Ajeganova, S., Fairé, U. D., Jogestrand, T., Frostegård, J., & Hafström, I. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.111334 · Cited by 67 · see citing works
Xiao, Y., Xiao, X., Zhang, X., Yi, D., Li, T., Hao, Q., Zhang, F., Xu, L., & Wang, N. (2024) · The EPMA Journal · doi:10.1007/s13167-024-00360-w · Cited by 64 · see citing works
- Authors
- Meisinger, C., Baumert, J., Khuseyinova, N., Loewel, H., & Koenig, W.
- Affiliations
- Universität Ulm (DE)
- From GSF the National Research Center for Environment and Health (C.M., J.B., H.L.), Institute of Epidemiology, Neuherberg; the Central Hospital of Augsburg (C.M., H.L.), MONICA/KORA Myocardial Infarction Registry, Augsburg; and the Department of Internal Medicine II–Cardiology (N.K., W.K), University of Ulm Medical Center, Ulm, Germany.
- Venue
- Circulation
- Published
- 2005-08-02
- Volume
- 112
- Issue
- 5
- Pages
- 651-657
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2143064104
- Cited by
- 434
- References
- 48
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 17 · 2018: 23 · 2017: 14 · 2016: 18 · 2015: 21 · 2014: 26 · 2013: 29 · 2012: 29
- FWCI
- 27.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidized LDL, acute coronary heart disease, cardiovascular risk prediction, risk indicators, middle-aged men, C-reactive protein, inflammation
- MeSH terms
- Acute Disease, Coronary Disease, Humans, Lipoproteins, LDL, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reference Values, Regression Analysis, Biomarkers
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