The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease
Abstract
Objectives— We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer’s disease (AD). Methods and Results— Fifty-four consecutive autopsy cases, 32 AD and 22 nondemented control subjects, were examined to establish the degree of arterial stenosis. Vessel external and lumenal area measurements were taken from 3-mm arterial cross-sections to calculate a stenosis index. AD patient circle of Willis arteries possessed a significant degree of stenosis as a consequence of multiple and severe atherosclerotic lesions. These lesions were significantly more severe in AD cases than in age-matched controls ( P <0.0001), and the number of stenoses and the index of occlusion ( R =0.67; P <0.00001) were positively correlated. In addition, the index of stenosis significantly correlated with the following measures of AD neuropathological lesions: total plaque score, neuritic plaque score, neurofibrillary tangle score, Braak stage score, and white matter rarefaction score. Conclusions— Our study reveals an association between severe circle of Willis atherosclerosis and sporadic AD that should be considered a risk factor for this dementia. These observations strongly suggest that atherosclerosis-induced brain hypoperfusion contributes to the clinical and pathological manifestations of AD.
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Cites
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Hypertension Is Related to Cognitive Impairment: A 20-Year Follow-up of 999 Men
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Cited by
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
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“…process that is strongly influenced by cerebrovascular dysfunction, connected through cerebral hypoperfusion, blood– brain barrier compromise, inflammatory cell infiltration, and hemorrhagic susceptibility (Roher et al., 2003; Beach et al., 2007; Brundel et al., 2012; Yarchoan et al., 2012).”
BackgroundThe age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138
Arvanitakis, Z., Capuano, A. W., Leurgans, S. E., Bennett, D. A., & Schneider, J. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30029-1 · Cited by 581
Casserly, I., & Topol, E. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15900-x · Cited by 560
Metadata
- Authors
- Roher, A. E., Esh, C., Kokjohn, T. A., Kalback, W., Luehrs, D. C., Seward, J. D., Sue, L. I., & Beach, T. G.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-11
- Volume
- 23
- Issue
- 11
- Pages
- 2055-2062
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2102716324
- Cited by
- 280
- References
- 13
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- closed
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