The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Progression of Coronary Artery Calcium and Risk of First Myocardial Infarction in Patients Receiving Cholesterol-Lowering Therapy
Open accessAbstract
Objective— Statins reduce cardiovascular risk and slow progression of coronary artery calcium (CAC). We investigated whether CAC progression and low-density lipoprotein (LDL) reduction have a complementary prognostic impact. Methods and Results— We measured the change in CAC in 495 asymptomatic subjects submitted to sequential electron-beam tomography (EBT) scanning. Statins were started after the initial EBT scan. Myocardial infarction (MI) was recorded in 41 subjects during a follow-up of 3.2±0.7 years. Mean LDL level did not differ between groups (118±25 mg/dL versus 122±30 mg/dL, MI versus no MI). On average, MI subjects demonstrated a CAC change of 42%±23% yearly; event-free subjects showed a 17%±25% yearly change ( P =0.0001). Relative risk of having an MI in the presence of CAC progression was 17.2-fold (95% CI: 4.1 to 71.2) higher than without CAC progression ( P <0.0001). In a Cox proportional hazard model, the follow-up score ( P =0.034) as well as a score change >15% per year ( P <0.001) were independent predictors of time to MI. Conclusions— Progression of CAC was significantly greater in patients receiving statins who had an MI compared with event-free subjects despite similar LDL control. Continued expansion of CAC may indicate failure of some patients to benefit from statin therapy and an increased risk of having cardiovascular events.
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Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
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Cited by
Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., Liu, K., Shea, S., Szklo, M., Bluemke, D. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072100 · Cited by 2,989
Greenland, P., Bonow, R. O., Brundage, B. H., Budoff, M. J., Eisenberg, M. J., Grundy, S. M., Lauer, M. S., Post, W. S., Raggi, P., Redberg, R. F., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.001 · Cited by 962
Self-citationSchroeder, S., Achenbach, S., Bengel, F., Burgstahler, C., Cademartiri, F., de Feyter, P., George, R., Kaufmann, P., Kopp, A. F., Knuuti, J., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehm544 · Cited by 554
Progression of Coronary Calcium and Incident Coronary Heart Disease Events
Budoff, M. J., Young, R., Lopez, V. A., Kronmal, R. A., Nasir, K., Blumenthal, R. S., Detrano, R. C., Bild, D. E., Guerci, A. D., Liu, K., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.12.035 · Cited by 422
Metadata
- Authors
- Raggi, P., Callister, T. Q., & Shaw, L. J.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-07
- Volume
- 24
- Issue
- 7
- Pages
- 1272-1277
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2101432029
- Cited by
- 320
- References
- 25
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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