Cited by 141Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionCardiovascular, Neuropeptides, and Oxidative Stress Research

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Mechanisms of Inducible Nitric Oxide Synthase–Mediated Vascular Dysfunction

Gunnett, C.A., Lund, D.D., McDowell, A.K., Faraci, F.M., Heistad, D.D.·2005·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000172626.00296.ba

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Abstract

Objective— Inducible nitric oxide synthase (iNOS) is expressed in arteries during inflammation and may contribute to vascular dysfunction. Effects of gene transfer of iNOS to carotid arteries were examined in vitro in the absence of systemic inflammation to allow examination of mechanisms by which iNOS impairs contraction and relaxation. Methods and Results— After gene transfer of iNOS with an adenovirus (AdiNOS), constrictor responses to phenylephrine (PE) and U46619 were impaired. After AdiNOS, inhibition of soluble guanylate cyclase (sGC) with 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ) reduced the EC 50 for PE from 4.33±0.78 μmol/L to 1.15±0.43 μmol/L (mean±SEM). These results imply that iNOS impairs contraction by activation of the NO/cGMP pathway. Relaxation to acetylcholine (ACh) also was impaired after AdiNOS. Sepiapterin (300 μmol/L), the precursor for tetrahydrobiopterin (BH 4 ), improved relaxation to Ach. Because BH 4 is an essential cofactor for production of NO by both iNOS and endothelial nitric oxide synthase (eNOS), these results suggest that iNOS may reduce production of NO by eNOS by limiting availability of BH 4 . Next, we examined effects of expression of iNOS in endothelium and adventitia. Selective expression of iNOS in endothelium, but not adventitia, impaired contraction to phenylephrine and relaxation to acetylcholine. Conclusions— We conclude that: (1) iNOS may impair contraction in part by activation of sGC; (2) iNOS impairs relaxation, at least in part, by limiting availability of BH 4 ; and (3) expression of iNOS in endothelium may be a more important mediator of vascular dysfunction than expression of iNOS in adventitia.

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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite, J., Southam, E., Boulton, C. L., Nielsen, E. B., Schmidt, K., & Mayer, B. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10233-2 · Cited by 1,101
Enzymatic function of nitric oxide synthases
Andrew, P. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00115-7 · Cited by 776
BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN
Nichol, C. A., Smith, G. K., & Duch, D. S. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.003501 · Cited by 558
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
Alp, N. J., & Channon, K. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110785.96039.f6 · Cited by 536
Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase
Friebe, A., & Koesling, D. (2003) · Circulation Research · doi:10.1161/01.res.0000082524.34487.31 · Cited by 508
Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function
Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 492
Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels
Wilcox, J. N., Subramanian, R. R., Sundell, C. L., Tracey, W. R., Pollock, J. S., Harrison, D. G., & Marsden, P. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2479 · Cited by 478

Show all 42 references

Research works printed but not linked: 9

10.1161/str.27.8.1373 · DOI
10.1161/atvb.21.8.1281 · DOI
10.1161/res.34.3.317 · DOI
10.1161/hyp.33.5.1225 · DOI
2000, Physiol Res, 49, 19
1995, Mol Pharmacol, 48, 184
10.1161/atvb.17.11.2479 · DOI
1999, Proc Natl Acad Sci, 95, 9220
2004, Biochem Biophys, 41, 415

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Authors: Gunnett, C. A., Lund, D. D., McDowell, A. K., Faraci, F. M., & Heistad, D. D.
Affiliations: University of Iowa (US)
ORCID: Faraci, F.M.
Heistad, D.D.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-08
Volume: 25
Issue: 8
Pages: 1617-1622
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000172626.00296.ba
OpenAlex: W2122779791
Semantic Scholar: 57eb0f4740d865d3a49ffe67ba8b437731ac61bb
Cited by: 141
References: 42
Citations by year: 2026: 3 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 11 · 2013: 5 · 2012: 3
FWCI: 3.21
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Roy J. Carver Charitable Trust
National Institutes of Health
National Heart, Lung, and Blood Institute (HL-16066, P01HL062984, HL-62984, HL38901)
National Institute of Neurological Disorders and Stroke (NS24621, P01NS024621)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: inducible nitric oxide synthase, vascular dysfunction, gene transfer, adenoviral vector, soluble guanylate cyclase, NO-cGMP pathway, tetrahydrobiopterin, endothelial nitric oxide synthase, endothelium, adventitia, vasoconstriction, vasorelaxation, acetylcholine, phenylephrine, sepiapterin, inflammation
MeSH terms: Adenoviridae, Animals, Carotid Arteries, Carotid Artery Diseases, Endothelium, Vascular, Male, Rabbits, Vasculitis, Vasoconstriction, Vasodilation, Gene Expression Regulation, Enzymologic, Gene Transfer Techniques, Nitric Oxide Synthase Type II

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Mechanisms of Inducible Nitric Oxide Synthase–Mediated Vascular Dysfunction

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