The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin
Abstract
Abstract Human vascular endothelial cadherin (VE-cadherin, 7B4/cadherin-5) is an endothelial-specific cadherin localized at the intercellular junctions. To directly investigate the functional role of this molecule we cloned the full-length cDNA from human endothelial cells and transfected its coding region into Chinese hamster ovary cells. The product of the transfected cDNA had the same molecular weight as the natural VE-cadherin in human endothelial cells, and reacted with several VE-cadherin mouse monoclonal antibodies. Furthermore, it selectively concentrated at intercellular junctions, where it codistributed with α-catenin. VE-cadherin conferred adhesive properties to transfected cells. It mediated homophilic, calcium-dependent aggregation and cell-to-cell adhesion. In addition, it decreased intercellular permeability to high–molecular weight molecules and reduced cell migration rate across a wounded area. Thus, VE-cadherin may exert a relevant role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
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Cites
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
The role of integrins in the maintenance of endothelial monolayer integrity.
Lampugnani, M. G., Resnati, M., Dejana, E., & Marchisio, P. C. (1991) · The Journal of cell biology · doi:10.1083/jcb.112.3.479 · Cited by 292
Self-citation
Cited by
Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Schulz, B., Pruessmeyer, J., Maretzky, T., Ludwig, A., Blobel, C. P., Saftig, P., & Reiss, K. (2008) · Circulation Research · doi:10.1161/circresaha.107.169805 · Cited by 301
The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control
Dejana, E., & Vestweber, D. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394311-8.00006-6 · Cited by 203
Self-citationAllport, J. R., Muller, W. A., & Luscinskas, F. W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.1.203 · Cited by 199
Golovkine, G., Faudry, E., Bouillot, S., Voulhoux, R., Attrée, I., & Huber, P. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003939 · Cited by 78
Metadata
- Authors
- Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., Introna, M., Gulino, D., Lampugnani, M. G., & Dejana, E.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1995-08
- Volume
- 15
- Issue
- 8
- Pages
- 1229-1239
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2118278618
- Cited by
- 275
- References
- 3
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin. https://app.cochat.ai/papers/10.1161/01.atv.15.8.1229
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- Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., Introna, M., Gulino, D., Lampugnani, M. G., & Dejana, E. (1995). Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.15.8.1229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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