The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease
Abstract
Interleukin-1β (IL-1β ) is known to have a number of effects on the different cell types present within coronary arteries. In this study we identified the location and phenotype of cells containing IL-1β in human coronary artery specimens from patients suffering from either coronary atherosclerosis or cardiomyopathy and correlated the presence of IL-1β with disease severity. Luminal endothelial cells, adventitial vessel wall cells, and macrophages were double labeled immunohistochemically for IL-1β protein and a cell type–specific monoclonal antibody for either endothelial cells or macrophages. In situ hybridization was performed to locate the presence of IL-1β mRNA within the coronary artery wall. In this study IL-1β protein was found to be increased in the adventitial vessel walls of atherosclerotic coronary arteries compared with coronary arteries from nonischemic cardiomyopathic hearts. This increase was directly proportional to the severity of coronary atherosclerosis. IL-1β protein was also detected in luminal endothelium and macrophages of atherosclerotic coronary arteries and coronary arteries from nonischemic cardiomyopathic hearts. IL-1β mRNA was found in luminal endothelial cells, adventitial vessel endothelial cells, and macrophages. We conclude that IL-1β is produced by endothelial cells and macrophages in coronary arteries from ischemic hearts and to a lesser extent from nonischemic cardiomyopathic hearts.
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Cites
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Cited by
Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039
NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926
Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799
Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530
Koushki, K., Shahbaz, S. K., Mashayekhi, K., Sadeghi, M., Zayeri, Z. D., Taba, M. Y., Banach, M., Al-Rasadi, K., Johnston, T. P., & Sahebkar, A. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08791-9 · Cited by 382
Metadata
- Authors
- Galea, J., Armstrong, J., Gadsdon, P., Holden, H., Francis, S. E., & Holt, C. M.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1996-08
- Volume
- 16
- Issue
- 8
- Pages
- 1000-1006
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W1973351162
- Cited by
- 310
- References
- 40
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease. https://app.cochat.ai/papers/10.1161/01.atv.16.8.1000
- The paper
- Galea, J., Armstrong, J., Gadsdon, P., Holden, H., Francis, S. E., & Holt, C. M. (1996). Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.16.8.1000
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
