Cited by 453Antioxidant Activity and Oxidative StressEicosanoids and Hypertension PharmacologyInflammatory mediators and NSAID effects

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Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

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Patrono, Carlo, FitzGerald, Garret A.·1997·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.17.11.2309

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Abstract

Abstract Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF 2α has been described in association with cardiac reperfusion injury and with cardiovascular risk factors, including cigarette smoking, diabetes mellitus, and hypercholesterolemia. Besides providing a likely noninvasive index of lipid peroxidation in these settings, measurements of specific F 2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF 2α in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation, evidence that this is likely in vivo remains inadequate at this time.

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Effects of Rosuvastatin and Colestimide on Metabolic Parameters and Urinary Monocyte Chemoattractant Protein-1 in Type 2 Diabetic Patients with Hyperlipidemia
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Optimal suppression of thromboxane a2formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase-2 inhibitor
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Soluble P-Selectin and Proinflammatory Cytokines in Patients with Polygenic Type IIa Hypercholesterolemia
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The 5‐series F2‐isoprostanes possess no vasomotor effects in the rat thoracic aorta, the human internal mammary artery and the human saphenous vein
Marlière, S., Cracowski, J., Durand, T., Chavanon, O., Bessard, J., Guy, A., Stanke‐Labesque, F., Rossi, J., & Bessard, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704558 · Cited by 27
“…8-iso PGF2a, and 5-F2t-IsoP (isoprostaglandin F2a type VI), respectively from the 15-series and the 5-series, are currently quanti®able in plasma and urine, and are extensively used as clinical markers of lipid peroxidation in vascular diseases (Patrono & Fitzgerald, 1997, Cracowski et al., 2001).”
Method
Correlation of NO Metabolites and 8-Iso-Prostaglandin F 2a With Periventricular Hyperintensity Severity
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Effect of ascorbic acid supplementation on plasma isoprostanes in haemodialysis patients
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“In addition, the people receiving body massage should drink adequate amount of water before and after the massage session so as to prevent unusual episodes of rhabdomyolysisassociated ARF, which is exacerbated by volume depletion [3,4].”
Background
Synthesis of 2,3-Dinor-5,6-dihydro-15F 2t -isoprostane
Taber, D. F., & Kanai, K. (1999) · The Journal of Organic Chemistry · doi:10.1021/jo9910738 · Cited by 25
Effects of thiol antioxidant on Reduced Nicotinamide Adenine Dinucleotide Phosphate oxidase in hypertensive Dahl salt-sensitive rats
Zhang, L., Fujii, S., Igarashi, J., & Kosaka, H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.019 · Cited by 25
Are isoprostanes a clinical marker for antioxidant drug investigation?
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Antioxidants and coronary artery disease
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Lipids in vascular function
Sellmayer, A., Hrboticky, N., & Weber, P. C. (1999) · Lipids · doi:10.1007/bf02562222 · Cited by 25
N-(carboxymethyl)valine residues in hemoglobin (CMV-Hb) reflect accumulation of oxidative stress in diabetic patients
Shimada, S., Tanaka, Y., Ohmura, C., Tamura, Y., Shimizu, T., Uchino, H., Watada, H., Hirose, T., Nakaniwa, T., Miwa, S., et al. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.01.007 · Cited by 24
“However, the current clinical markers of ROS, such as urinary 8-OH-20-deoxyguanosine [6], urinary 8-iso PGF2a [7] and plasma lipid peroxide [8], all reflect short-term ROS formation and not cumulative oxidative stress.”
Background
Impact of atorvastatin treatment on platelet‐activating factor acetylhydrolase and 15‐F2trans‐isoprostane in hypercholesterolaemic patients
Kom, G. D., Schwedhelm, E., Maas, R., Schneider, L., Benndorf, R. A., & Böger, R. H. (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02832.x · Cited by 24
Age-Related Differences in Vasoconstrictor Responses to Isoprostanes in Piglet Pulmonary and Mesenteric Vascular Smooth Muscle
González-Luis, G. E., Pérez‐Vizcaíno, F., García-Muñoz, F., Mey, J. G. R. D., Blanco, C. E., & Villamor, E. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000161411.01208.83 · Cited by 24
“Although high concentrations of isoprostanes (in the micromolar range) were required to induce significant vascular contraction, high local concentrations of some of these compounds are found in clinical situations of oxidative injury (22,23).”
Background
Jenseits von Prostaglandinen – Chemie und Biologie radikalisch gebildeter cyclischer oxygenierter Metabolite von mehrfach ungesättigten Fettsäuren
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Measurement of 8-Iso-Prostaglandin F2α in Biological Fluids as a Measure of Lipid Peroxidation
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Endothelial Dysfunction and High Cardiovascular Risk Profile in Severe Alcoholics Improve Only Partially Following a Medium‐Term Alcohol Withdrawal
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The Formation of Phosphatidylcholine Oxidation Products by Stimulated Phagocytes
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“markers of lipid peroxidation and oxidative stress owing to their stability.([19,20]) A large number of different isomers may be formed, although much attention has focused on the F2-isoprostanes, especially 8-isoprostane F2a (formerly 8-isoPGF2a).”
Background
Serum Concentrations of F 2 -Isoprostanes and 4-Hydroxynonenal in Hemodialysis Patients in Relation to Inflammation and Renal Anemia
Wiswedel, I., Peter, D., Gardemann, A., Carluccio, F., Hampl, H., & Siems, W. (2008) · Biomarker Insights · doi:10.4137/bmi.s363 · Cited by 22
“They promote platelet activation (Patrono and Fitzgerald, 1997) and induce mitogenesis in vascular smooth muscle cells (Fukunaga et al. 1993).”
Background
α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress
Wada, H., Ura, S., Satoh‐Asahara, N., Kitaoka, S., Mashiba, S., Akao, M., Abe, M., Ono, K., Morimoto, T., Fujita, M., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.9035 · Cited by 22
Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge andin vivourinary thromboxane production in healthy male subjects
Simeoni, S., Biselli, R., D’Amelio, R., Rocca, B., Lattanzio, S., Mucci, L., Davı̀, G., & Patacchioli, F. R. (2011) · Stress · doi:10.3109/10253890.2010.545458 · Cited by 22
Increased isoprostane content in coronary plaques obtained from vulnerable patients
Nishibe, A., Kijima, Y., Fukunaga, M., Nishiwaki, N., Sakai, T., Nakagawa, Y., & Hata, T. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.03.001 · Cited by 22
“Urinary excretion of 8-iso-PGF2a has been proposed as a reliable biomarker for enhanced oxidant stress in patients with coronary heart disease [10,11].”
Background
Cardiac Function, Inflammatory Mediators and Mortality in Critical Limb Ischemia
Barani, J., Mattiasson, I., Lindblad, B., & Gottsäter, A. (2006) · Angiology · doi:10.1177/0003319706290743 · Cited by 22
“B-Hb, g/L (SD) 122 (19) 123 (18) 120 (20) 120 (17) 128 (20)6”
Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism
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“Measurement of unmetabolised F2-isoprostanes in plasma and urine has proved to be a valuable approach to assess the rate of lipid peroxidation in vivo (21).”
BackgroundSelf-citation
Effect of Strenuous Arm Exercise on Oxidized-LDL-Potentiated Platelet Activation in Individuals with Spinal Cord Injury
Yang, C., Wong, M.-K., Chow, S.-E., Chen, J.-K., & Wang, J.-S. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613978 · Cited by 21
“Enhanced urinary excretion of 8-iso-prostaglandin F2 (8-iso-PGF2 ) has been found associated with cardiovascular risk factors, including hypercholesterolemia, diabetes mellitus, and cigarette smoking (18, 36).”
Background
The role of lipid oxidation and oxidative lipid derivatives in the development of preeclampsia
Henriksen, T. (2000) · Seminars in Perinatology · doi:10.1016/s0146-0005(00)80051-8 · Cited by 21
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Calzada, C., Véricel, E., Colas, R. A., Guillot, N., Khoury, G. E., Drai, J., Sassolas, A., Peretti, N., Ponsin, G., Lagarde, M., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-225169 · Cited by 20
“It was associated with an increased lipid peroxidation in patients with ABLP, as shown by decreased plasma linoleic acid proportions in plasma and platelets, increased platelet concentrations of MDA, and increased concentrations of the urinary 8-epiPGF2 isoprostane, a reliable marker of in vivo lipid peroxidation (23).”
Background
Characterization of Ultrastructural and Metabolic Abnormalities In Semen from Men With Spinal Cord Injury
Monga, M., Dunn, K., & Rajasekaran, M. “. (2001) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2001.11753554 · Cited by 20
Statins and Oxidative Stress During Atherogenesis
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Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism – A Randomized Controlled Trial
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The Role of Mild Systemic Heat and Physical Activity on Endothelial Function in Patients with Increased Cardiovascular Risk: Results from a Systematic Review
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An Update of the Effect of Far Infrared Therapy on Arteriovenous Access in End-stage Renal Disease Patients
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“FIR dry sauna, given 45 min/day for 2 weeks, has been shown to reduce both systolic BP and the increased urinary 8-epi-prostaglandin F2α level, a reliable marker of oxidative stress in vivo (10, 45).”
Background
Circulating Lp-PLA2 activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy
Paik, J. K., Kim, M., Kim, M., Yen, Y. Y., Ahn, H. Y., Lee, S., & Lee, J. H. (2015) · AGE · doi:10.1007/s11357-015-9770-4 · Cited by 19
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Epigenetic Manifestation of Metabolic Syndrome and Dietary Management
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Atorvastatin-Induced Changes in Plasma Coenzyme Q10 and Brain Natriuretic Peptide in Patients With Coronary Artery Disease
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Patients with microvascular obstruction after primary percutaneous coronary intervention show a gp91phox (NOX2) mediated persistent oxidative stress after reperfusion
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Authors: Patrono, C., & FitzGerald, G. A.
Affiliations: University of Pennsylvania (US)
ORCID: Patrono, Carlo
FitzGerald, Garret A.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1997-11
Volume: 17
Issue: 11
Pages: 2309-2315
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.17.11.2309
OpenAlex: W2087724955
Cited by: 453
References: 61
Citations by year: 2026: 1 · 2025: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 15
FWCI: 20.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bayer
Wellcome Trust
European Commission
National Institutes of Health
National Heart, Lung, and Blood Institute (P50HL054500, 1P50HL54500)
National Center for Research Resources (MO1-RR-00040, M01RR000040)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: isoprostanes, lipid peroxidation, oxidative stress, arachidonic acid metabolism, atherothrombosis, urinary biomarkers, cardiovascular risk factors, smoking, diabetes mellitus, hypercholesterolemia, ischemia-reperfusion injury, lipid peroxidation inhibitors, dose-finding
MeSH terms: Antioxidants, Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Free Radicals, Humans, Hyperlipidemias, Immunoassay, Indicator Dilution Techniques, Gas Chromatography-Mass Spectrometry, Platelet Aggregation, Prostaglandins F, Risk Factors, Thrombosis, Vasoconstrictor Agents, Lipid Peroxidation, Dinoprost, Biomarkers, Oxidative Stress, F2-Isoprostanes

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Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

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