Cited by 453Antioxidant Activity and Oxidative StressEicosanoids and Hypertension PharmacologyInflammatory mediators and NSAID effects

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Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

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Patrono, Carlo, FitzGerald, Garret A.·1997·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.17.11.2309

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Abstract

Abstract Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF 2α has been described in association with cardiac reperfusion injury and with cardiovascular risk factors, including cigarette smoking, diabetes mellitus, and hypercholesterolemia. Besides providing a likely noninvasive index of lipid peroxidation in these settings, measurements of specific F 2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF 2α in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation, evidence that this is likely in vivo remains inadequate at this time.

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Authors: Patrono, C., & FitzGerald, G. A.
Affiliations: University of Pennsylvania (US)
ORCID: Patrono, Carlo
FitzGerald, Garret A.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1997-11
Volume: 17
Issue: 11
Pages: 2309-2315
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.17.11.2309
OpenAlex: W2087724955
Cited by: 453
References: 61
Citations by year: 2026: 1 · 2025: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 15
FWCI: 20.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Bayer
Wellcome Trust
European Commission
National Institutes of Health
National Heart, Lung, and Blood Institute (P50HL054500, 1P50HL54500)
National Center for Research Resources (MO1-RR-00040, M01RR000040)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: isoprostanes, lipid peroxidation, oxidative stress, arachidonic acid metabolism, atherothrombosis, urinary biomarkers, cardiovascular risk factors, smoking, diabetes mellitus, hypercholesterolemia, ischemia-reperfusion injury, lipid peroxidation inhibitors, dose-finding
MeSH terms: Antioxidants, Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Free Radicals, Humans, Hyperlipidemias, Immunoassay, Indicator Dilution Techniques, Gas Chromatography-Mass Spectrometry, Platelet Aggregation, Prostaglandins F, Risk Factors, Thrombosis, Vasoconstrictor Agents, Lipid Peroxidation, Dinoprost, Biomarkers, Oxidative Stress, F2-Isoprostanes

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Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

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