The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Group II Secretory Phospholipase A2in Atherosclerosis: 1. Increased Atherogenesis and Altered Lipoproteins in Transgenic Mice Expressing Group IIa Phospholipase A2
Open accessAbstract
Abstract—Some observations have suggested that the extracellular group IIa phospholipase A 2(sPLA 2), previously implicated in chronic inflammatory conditions such as arthritis, may contribute to atherosclerosis. We have examined this hypothesis by studying transgenic mice expressing the human enzyme. Compared with nontransgenic littermates, the transgenic mice exhibited dramatically increased atherosclerotic lesions when maintained on a high-fat, high-cholesterol diet. Surprisingly, the transgenic mice also exhibited significant atherosclerotic lesions when maintained on a low-fat chow diet. Immunohistochemical staining indicated that sPLA 2 was present in the atherosclerotic lesions of the transgenic mice. On both chow and atherogenic diets, the transgenic mice exhibited decreased levels of HDLs and slightly increased levels of LDLs compared with nontransgenic littermates. These data indicate that group IIa sPLA 2 may promote atherogenesis, in part, through its effects on lipoprotein levels. These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases.
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Citations
Cites
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Cited by
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,839
Self-citationKhovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
Dennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
Boudreau, L. H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G. S., Lévesque, T., et al. (2014) · Blood · doi:10.1182/blood-2014-05-573543 · Cited by 703
Biochemistry and Physiology of Mammalian Secreted Phospholipases A2
Lambeau, G., & Gelb, M. H. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.062405.154007 · Cited by 513
Metadata
- Authors
- Ivandic, B., Castellani, L. W., Wang, X.-P., Qiao, J.-H., Mehrabian, M., Navab, M., Fogelman, A. M., Grass, D. S., Swanson, M. E., de Beer, M. C., de Beer, F., & Lusis, A. J.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1999-05
- Volume
- 19
- Issue
- 5
- Pages
- 1284-1290
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2122602300
- Cited by
- 244
- References
- 1
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ivandic, B., Castellani, L. W., Wang, X.-P., Qiao, J.-H., Mehrabian, M., Navab, M., Fogelman, A. M., Grass, D. S., Swanson, M. E., de Beer, M. C., de Beer, F., & Lusis, A. J. (1999). Role of Group II Secretory Phospholipase A2in Atherosclerosis: 1. Increased Atherogenesis and Altered Lipoproteins in Transgenic Mice Expressing Group IIa Phospholipase A2. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.19.5.1284
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