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Cited by 76Blood properties and coagulationInflammatory Biomarkers in Disease PrognosisLipoproteins and Cardiovascular Health

Plasma Fibrinogen as a Predictor of Total and Cause-Specific Mortality in Elderly Japanese-American Men

Yano, Katsuhiko, Grove, John S., Chen, Randi, Rodriguez, Beatriz L., Curb, J. David, Tracy, Russell P.·2001·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/01.atv.21.6.1065
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Abstract

Abstract —The relation between plasma fibrinogen and total and cause-specific mortality was investigated in a cohort of 3571 Japanese-American men aged 71 to 93 years during a median follow-up of 4.4 years. There were a total of 728 deaths, of which 37% were accounted for by cardiovascular disease and 27% by cancer. The age-adjusted relative risk (RR) for total mortality in the top quintile of fibrinogen (>3.51 g/L) compared with the bottom quintile (<2.57 g/L) was 4.3 ( P <0.0001) in the first year of follow-up. RR was reduced to 1.7 in the second year but remained significantly and slightly increased in subsequent years. After adjustment for age and confounding risk factors, the RRs (and 95% confidence intervals) associated with a 1-SD increment of fibrinogen (0.64 g/L) for all-cause, cardiovascular disease, cancer, and other-cause mortality were 1.3 (1.2 to 1.4), 1.2 (1.1 to 1.4), 1.3 (1.2 to 1.5), and 1.3 (1.2 to 1.5), respectively. Preexisting diseases did not influence the significant association of fibrinogen with mortality. There was a significant interaction of fibrinogen with white blood cell count but not with cigarette smoking. We conclude that plasma fibrinogen is an independent risk factor for mortality from a broad spectrum of diseases in elderly men and that this universal effect of fibrinogen on mortality may be mediated partly through inflammation.

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Crossref · 10.1161/01.atv.21.6.1065

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  • Fibrinogen is an excellent predictor of mortality especially in patients with cardiovascular complications.

    “Fibrinogen is an excellent predictor of mortality especially in patients with cardiovascular complications [11, 12].”

    From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [11]

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Authors
Yano, K., Grove, J. S., Chen, R., Rodriguez, B. L., Curb, J. D., & Tracy, R. P.
Affiliations
  • University of Vermont (US)
  • From the Honolulu Heart Program, Kuakini Medical Center (K.Y., R.C., B.L.R., J.D.C.), Honolulu, Hawaii; the Division of Clinical Epidemiology, Department of Medicine (K.Y., R.C., B.L.R., J.D.C.), and the Biostatistics Program, Department of Public Health (J.S.G.), John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii; and the Department of Pathology (R.P.T.), University of Vermont, Laboratory for Clinical Biochemistry Research, Colchester.
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-06
Volume
21
Issue
6
Pages
1065-1070
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/01.atv.21.6.1065
OpenAlex
W2132305327
Cited by
76
References
38
Citations by year
2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
4.10
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc005102-027, 5u01hl056274-05)
  • National Heart, Lung, and Blood Institute (N01 HC 05102, U01HL56274)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
fibrinogen, mortality prediction, cause-specific mortality, cardiovascular mortality, cancer mortality, older men, Japanese-American men, inflammation, cardiovascular risk factors
MeSH terms
Aged, Americas, Fibrinogen, Follow-Up Studies, Heart Diseases, Humans, Japan, Male, Middle Aged, Neoplasms, Prospective Studies, Risk Factors, Cohort Studies, Biomarkers, Survival Rate, Myocardial Ischemia

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