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Lipoprotein oxidation and lipoprotein-induced cytotoxicity.
Open accessAbstract
The results of this study indicate that when human VLDL or LDL is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can be predicted by assaying for the presence of thiobarbituric acid-reacting substances on the lipoprotein. However, malondialdehyde, which reacts with thiobarbituric acid and is known to be injurious to cells, was not cytotoxic in the same experimental system when dissolved in culture medium or covalently bound to non-toxic LDL. The toxic agent(s) on oxidized LDL is(are) located in a lipid-extractable moiety. Since lipid peroxides and oxidized sterols can occur in vivo under various pathological conditions, the cytotoxicity of these lipoprotein-associated substances observed in vitro may be related to certain manifestations of these conditions.
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Citations
Cited by
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
Steinberg, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,642
Free Radicals as Mediators of Tissue Injury and Disease
Kehrer, J. P. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104073 · Cited by 1,455
Mechanisms of free radical oxidation of unsaturated lipids
Porter, N. A., Caldwell, S. E., & Mills, K. A. (1995) · Lipids · doi:10.1007/bf02536034 · Cited by 1,208
The oxidative modification hypothesis of atherogenesis: an overview
Chisolm, G. M., & Steinberg, D. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00344-0 · Cited by 746
Self-citationPryor, W. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00224-5 · Cited by 451
Metadata
- Authors
- Hessler, J. R., Morel, D. W., Lewis, L. J., & Chisolm, G. M.
- Venue
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Published
- 1983-05
- Volume
- 3
- Issue
- 3
- Pages
- 215-222
- ISSN
- 0276-5047 (ISSN-L)
- OpenAlex
- W2070951814
- Cited by
- 541
- References
- 0
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Lipoprotein oxidation and lipoprotein-induced cytotoxicity. https://app.cochat.ai/papers/10.1161/01.atv.3.3.215
- The paper
- Hessler, J. R., Morel, D. W., Lewis, L. J., & Chisolm, G. M. (1983). Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis: An Official Journal of the American Heart Association, Inc. https://doi.org/10.1161/01.atv.3.3.215
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
