Cited by 213Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiac pacing and defibrillation studies

Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler–Derived Isovolumic Acceleration: Validation in an Animal Model

Vogel, Michael, Cheung, Michael M.H., Li, Jia, Kristiansen, Steen B., Schmidt, Michael R., White, Paul A., Sorensen, Keld, Redington, Andrew N.·2003·Circulation

Abstract

Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental preparation. Methods and Results— In study 1, we examined 6 pigs by use of tissue Doppler imaging of LV free wall and simultaneous measurements of intraventricular pressure, volume, maximal elastance (E max ), and dP/dt max by conductance catheterization. Animals were paced via the right atrium at a rate of 130 bpm. IVA was compared with elastance during contractility modulation by esmolol and dobutamine and assessed during preload reduction and afterload increase. In study 2, in 6 more pigs, force-frequency data were obtained during incremental atrial pacing from 120 to 180 bpm. Study 1: Esmolol led to a decrease in IVA and E max ( P <0.03 and <0.02, respectively), both of which increased during dobutamine infusion ( P <0.02 and <0.03, respectively). IVA was unaffected by significant ( P <0.001) acute reduction of LV volume and a significantly increased LV afterload (systolic pressure increase, P <0.001). Study 2: There was a positive correlation between IVA and dP/dt max ( r 2 =0.92, P <0.05). As heart rate was increased from 120 to 160 bpm, there were significant increases in both IVA and dP/dt max ( P <0.0004 and P =0.02, respectively). Over the same range of heart rates, there was no significant change in E max ( P =0.22). Conclusions— IVA is a measurement of LV contractile function that is unaffected by preload and afterload changes within a physiological range and can be used noninvasively to measure LV force-frequency relationships.

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Crossref · 10.1161/01.cir.0000058171.62847.90

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Authors
Vogel, M., Cheung, M. M. H., Li, J., Kristiansen, S. B., Schmidt, M. R., White, P. A., Sorensen, K., & Redington, A. N.
Affiliations
  • Royal Papworth Hospital (GB)
  • National Health Service (GB)
  • From the Cardiothoracic Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK (M.V.); Division of Cardiology, Hospital for Sick Children, Toronto, Canada (M.M.H.C., J.L., A.N.R.); Department of Experimental Research and Cardiology, Skejby Hospital, Aarhus, Denmark (S.B.K., M.R.S., K.S.); and Papworth Hospital, Cambridge, UK (P.A.W.).
Venue
Circulation
Published
2003-04
Volume
107
Issue
12
Pages
1647-1652
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2076658601
Cited by
213
References
20
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 17 · 2013: 8 · 2012: 11
FWCI
9.88
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
isovolumic acceleration, left ventricular contractility, force-frequency relationship, tissue Doppler imaging, dP/dtmax, esmolol, dobutamine, heart rate, preload, afterload, non-invasive assessment
MeSH terms
Animals, Cardiac Pacing, Artificial, Heart Ventricles, Myocardial Contraction, Swine, Echocardiography, Doppler, Observer Variation, Ventricular Function, Ventricular Function, Left, Ventricular Pressure

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