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Cited by 279

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice

Burleigh, Michael E., Babaev, Vladimir R., Oates, John A., Harris, Raymond C., Gautam, Shiva, Riendeau, Denis, Marnett, Lawrence J., Morrow, Jason D., Fazio, Sergio, Linton, MacRae F.·2002·Circulation
DOI 10.1161/01.cir.0000014927.74465.7f
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Abstract

Background — Atherosclerosis has features of an inflammatory disease. Because cyclooxygenase (COX)-2 is expressed in atherosclerotic lesions and promotes inflammation, we tested the hypotheses that selective COX-2 inhibition would reduce early lesion formation in LDL receptor–deficient (LDLR −/− ) mice and that macrophage COX-2 expression contributes to atherogenesis in LDLR −/− mice. Methods and Results — Treatment of male LDLR −/− mice fed the Western diet with rofecoxib or indomethacin for 6 weeks resulted in significant reductions in atherosclerosis in the proximal aorta (25% and 37%) and in the aorta en face (58% and 57%), respectively. Rofecoxib treatment did not inhibit platelet thromboxane production, a COX-1–mediated process, but it significantly reduced the urinary prostacyclin metabolite 2,3-dinor-6-keto-PGF 1α . Fetal liver cell transplantation was used to generate LDLR −/− mice null for expression of the COX-2 gene by macrophages. After 8 weeks on the Western diet, COX-2 −/− →LDLR −/− mice developed significantly less (33% to 39%) atherosclerosis than control COX-2 +/+ →LDLR −/− mice. In both the inhibitor studies and the transplant studies, serum lipids did not differ significantly between groups. Conclusions — The present studies provide strong pharmacological and genetic evidence that COX-2 promotes early atherosclerotic lesion formation in LDLR −/− mice in vivo. These results support the potential of anti-inflammatory approaches to the prevention of atherosclerosis. (Circulation. 2002;105:1816-1823.)

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Metadata

Authors
Burleigh, M. E., Babaev, V. R., Oates, J. A., Harris, R. C., Gautam, S., Riendeau, D., Marnett, L. J., Morrow, J. D., Fazio, S., & Linton, M. F.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-04-16
Volume
105
Issue
15
Pages
1816-1823
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000014927.74465.7f
OpenAlex
W2061857216
Cited by
279
References
37
FWCI
9.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice. https://app.cochat.ai/papers/10.1161/01.cir.0000014927.74465.7f
The paper
Burleigh, M. E., Babaev, V. R., Oates, J. A., Harris, R. C., Gautam, S., Riendeau, D., Marnett, L. J., Morrow, J. D., Fazio, S., & Linton, M. F. (2002). Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice. Circulation. https://doi.org/10.1161/01.cir.0000014927.74465.7f

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.