Familial aggregation of blood lipid response to exercise training in the health, risk factors, exercise training, and genetics (HERITAGE) Family Study.
Abstract
Background Fasting levels of plasma lipids and lipoproteins are reported to improve with regular exercise training. However, little is known on whether the training responses are influenced by heritable factors. Methods and results The lipid profile was assessed in 115 black (224 individuals) and 99 white families (469 individuals), who participated in the HERITAGE Family Study, while in a sedentary state (baseline visit) and after exercise training for 20 weeks (post visit). Variables included total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I, and HDL-C subfractions 2 (HDL2-C) and 3 (HDL3-C). Familial correlations for the training responses (Delta=post-baseline) were significant for most variables, and the percent variance accounted for by familial factors (ie, maximal heritabilities) ranged from 25% to 38%. Exceptions were for higher heritabilities near 60% for DeltaApoB in blacks and DeltaHDL2-C in whites and a lower estimate of zero for DeltaLDL-C in blacks. Conclusions Heritable factors in part determine lipid profile responses to regular exercise. Maximal heritabilities were similar across ethnic groups and variables, except for DeltaLDL-C, DeltaApoB, and DeltaHDL2-C. Molecular studies to identify the markers and genes associated with these influences are currently underway.
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The heritability of exercise-induced changes reached about 30% for plasma HDL-C and triglycerides and about 20% to 25% for indicators of insulin metabolism and resting systolic blood pressure.
“In fact, the heritability of the changes induced by the exercise program reached about 30% for plasma HDL-C and TG [26] and about 20% to 25% for indicators of insulin metabolism and resting SBP [29], [30].”
From Adverse metabolic response to regular exercise: is it a rare or common occurrence? (2012) · cites this paper as [26]
The response pattern to exercise training aggregates in families.
“Research based on HERITAGE has amply demonstrated that the response pattern to exercise training aggregates in families [25], [26], [27], 28.”
From Adverse metabolic response to regular exercise: is it a rare or common occurrence? (2012) · cites this paper as [26]
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Aims, design, and measurement protocol
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Variability in the Response of HDL Cholesterol to Exercise Training in the HERITAGE Family Study
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Adverse metabolic response to regular exercise: is it a rare or common occurrence?
Bouchard, C., Blair, S. N., Church, T. S., Earnest, C. P., Hagberg, J. M., Häkkinen, K., Jenkins, N. T., Karavirta, L., Kraus, W. E., Leon, A. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037887 · Cited by 389 · see citing works
Self-citationMann, T. N., Lamberts, R. P., & Lambert, M. I. (2014) · Sports Medicine · doi:10.1007/s40279-014-0197-3 · Cited by 379 · see citing works
SARZYNSKI, M. A., RICE, T. K., DESPRÉS, J.-P., PÉRUSSE, L., TREMBLAY, A., STANFORTH, P. R., TCHERNOF, A., BARBER, J. L., FALCIANI, F., CLISH, C., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002859 · Cited by 62 · see citing works
Self-citationLakka, H.-M., Tremblay, A., Després, J.-P., & Bouchard, C. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.09.012 · Cited by 17 · see citing works
Self-citation
- Authors
- Rice, T., Després, J.-P., Pérusse, L., Hong, Y., Province, M. A., Bergeron, J., Gagnon, J., Leon, A. S., Skinner, J. S., Wilmore, J. H., Bouchard, C., & Rao, D. C.
- Affiliations
- Pennington Biomedical Research Center (US)
- From the Division of Biostatistics (T.R., Y.H., M.A.P., D.C.R.) and Departments of Genetics and Psychiatry (D.C.R.), Washington University School of Medicine, St Louis, Mo; Physical Activity Sciences Laboratory (J.-P.D., L.P.), Lipid Research Center (J.-P.D., J.B.), and Molecular Endocrinology Laboratory (J.G.), Laval University, Québec, Canada; School of Kinesiology and Leisure Studies (A.S.L.), University of Minnesota, Minneapolis; Department of Kinesiology (J.S.S.), Indiana University,...
- ORCID
- Venue
- Circulation
- Published
- 2002-04-23
- Volume
- 105
- Issue
- 16
- Pages
- 1904-1908
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2127336912
- Cited by
- 65
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL047327, HL 47321, HL 45670, HL47323, R01HL047317, HL 47327, R01HL047323, HL47317, R01HL045670, R01HL047321)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- exercise training, serum lipids, heritability, familial aggregation, lipid profile, LDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein A-I, HDL subfractions, genetic factors, sedentary lifestyle, black and white populations
- MeSH terms
- Adolescent, Adult, Coronary Disease, Family Health, Female, Humans, Lipids, Lipoproteins, Male, Middle Aged, Risk Factors, Genetic Variation, Exercise, Black People, White People
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