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Cited by 116Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

Variability in the Response of HDL Cholesterol to Exercise Training in the HERITAGE Family Study

Leon, A. S., Gaskill, S. E., Rice, T., Bergeron, J., Gagnon, J., Rao, D. C., Skinner, J. S., Wilmore, J. H. +1 more·2002·International Journal of Sports Medicine
DOI 10.1055/s-2002-19270
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Abstract

In the HERITAGE Family Study, 675 sedentary, healthy, white and black men and women, aged 17 to 65 years, performed 20 weeks of supervised cycle ergometer exercise at the same relative intensity and weekly volume. As a group, subjects had normal mean baseline lipid levels for North Americans with the exception of below average high density lipoprotein cholesterol (HDL-C) levels. A significant mean increase in plasma HDL-C of 3.6 % was observed; however, there was marked variability in responsiveness to training, ranging from a mean 9.3 % decrease in Quartile 1 of HDL-C response to a mean 18 % increase in Quartile 4 (P < 0.0001 by ANOVA). Parallel changes in HDL(2)-C and HDL(3)-C, apolipoprotein A-I levels, and lipoprotein lipase activity were noted across quartiles. The change in HDL-C across quartiles was inversely related to baseline HDL-C (p < 0.0001) and to changes with training in plasma triglycerides (p = 0.0007). No significant differences in HDL-C response were observed across quartiles by sex, race, age, or increase in VO(2)max with training; however, weak positive associations were observed with age-adjusted education level and with reduction in abdominal fat and increase in VO(2)max at the ventilatory threshold following training. Multivariate regression analysis including baseline variables and training responses only accounted for 15.5 % of the variability in the HDL-C response to training. Thus, marked variability was found in the HDL-C response to the same endu…

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  • There is considerable interindividual variability in the ability to improve cardiorespiratory fitness and cardiometabolic and diabetes risk factor profile in response to regular exercise.

    “However, there is considerable interindividual variability in the ability to improve one's cardiorespiratory fitness and cardiometabolic and diabetes risk factor profile in response to regular exercise. This clear finding of the HERITAGE Family Study has been replicated [3], [4], [5], [6].”

    From Adverse metabolic response to regular exercise: is it a rare or common occurrence? (2012) · cites this paper as [5]

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Authors
Leon, A. S., Gaskill, S. E., Rice, T., Bergeron, J., Gagnon, J., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C.
Affiliations
  • University of Minnesota (US)
  • University of Montana (US)
  • Washington University in St. Louis (US)
  • Centre hospitalier de l'Université Laval (CA)
  • Indiana University Bloomington (US)
  • Texas A&M University (US)
  • Pennington Biomedical Research Center (US)
ORCID
Venue
International Journal of Sports Medicine
Publisher
Georg Thieme Verlag KG
Published
2002-01
Volume
23
Issue
1
Pages
1-9
ISSN
  • 0172-4622 (ISSN-L)
  • 1439-3964
DOI
10.1055/s-2002-19270
OpenAlex
W2059409060
Cited by
116
References
0
Citations by year
2026: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 4
FWCI
19.77
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Minnesota
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL047327, R01HL47327, R01HL47321, R01HL047317, R01HL45670, R01HL47317, R01HL045670, R01HL047321)
  • National Center for Research Resources (M10-RR000400)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
HDL cholesterol, exercise training response, interindividual variability, endurance training, cycle ergometry, HDL2-C, HDL3-C, apolipoprotein A-I, lipoprotein lipase, plasma triglycerides, VO2max, ventilatory threshold, abdominal fat, sedentary adults, HERITAGE Family Study
MeSH terms
Adaptation, Physiological, Adolescent, Adult, Aged, Body Composition, Female, Humans, Life Style, Lipids, Cholesterol, HDL, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Social Class, Statistics as Topic, Exercise, Linear Models, Black People, White People

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