The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to α v -Integrins
Open accessAbstract
Background— Noninvasive methods for characterizing neovessel formation during angiogenesis are currently lacking. We hypothesized that angiogenesis could be imaged with the use of contrast-enhanced ultrasound (CEU) with microbubbles targeted to α v -integrins. Methods and Results— Microbubbles targeted to α v -integrins were prepared by conjugating echistatin (MB E ) or monoclonal antibody against murine α v (MB α ) to their surface. Control microbubbles (MB c ) were also prepared. The microvascular behavior of these microbubbles was assessed by intravital microscopy of the cremaster muscle in mice treated for 4 days with sustained-release FGF-2. Microvascular retention was much greater ( P <0.01) for MB E (11±6 mm −3 ) and MB α (10±7 mm −3 ) than that for MB c (1±1 mm −3 ). Retained MB E and MB α attached directly to the microvascular endothelial surface. Microbubble retention in 4 control mice was minimal. Subcutaneous matrigel plugs enriched with FGF-2 were created in 12 mice and studied 10 days later. Neovessels within the matrigel stained positive for α v -integrins. CEU demonstrated greater ( P <0.01) acoustic intensity for MB E (16.0±5.9 U) and MB α (17.0±5.5 U) compared with MB c (5.8±2.6 U). The signal from targeted microbubbles (MB E and MB α ) correlated well ( r =0.90) with the matrigel blood volume determined by CEU perfusion imaging. Conclusions— CEU with microbubbles targeted for α v -integrins may provide a noninvasive method for assessing therapeutic angiogenesis.
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Cites
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Self-citationDefinition of Two Angiogenic Pathways by Distinct α v Integrins
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Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
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Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.
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Echocardiographic Destruction of Albumin Microbubbles Directs Gene Delivery to the Myocardium
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Integrins in angiogenesis and lymphangiogenesis
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Microbubbles in medical imaging: current applications and future directions
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Self-citationMicrobubbles and ultrasound: from diagnosis to therapy
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Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery
Paefgen, V., Doleschel, D., & Kiessling, F. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00197 · Cited by 272
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Metadata
- Authors
- Leong-Poi, H., Christiansen, J., Klibanov, A. L., Kaul, S., & Lindner, J. R.
- Venue
- Circulation
- Published
- 2003-01-28
- Volume
- 107
- Issue
- 3
- Pages
- 455-460
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2062437832
- Cited by
- 334
- References
- 23
- FWCI
- 22.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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