The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice
Open accessAbstract
Background— Whether left ventricular hypertrophy (LVH) in obesity results from increased hemodynamic load or altered neurohormonal signaling remains controversial. Dysregulation of leptin, a neurohormone essential to energy homeostasis, is implicated in the pathogenesis of obesity. Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH. Methods and Results— We measured left ventricular (LV) wall thickness and LV mass with echocardiography in mice lacking leptin ( ob/ob , n=15) or functional receptor ( db/db , n=10) and controls at 2, 4, and 6 months of age. None of the mice had LVH at 2 months. Progressive obesity developed in ob/ob and db/db mice. At 6 months, LVH occurred in ob/ob and db/db compared with controls. We observed corresponding myocyte hypertrophy by light microscopy. To separate the direct contribution of leptin deficiency from mechanical effects of obesity, we induced weight loss in 6- to 8-month-old ob/ob mice either by leptin infusion or caloric restriction. Mice in both groups lost similar weight compared with placebo-treated controls. Leptin infusion completely reversed the increase in wall thickness with partial resolution of myocyte hypertrophy, whereas calorie-restricted mice had no decrease in wall thickness and a lesser change in myocyte size. Conclusions— Together these data show that the effect of leptin on LV remodeling is not attributable to weight loss alone, indicating that leptin has antihypertrophic effects on the heart, either directly or through a leptin-regulated neurohumoral pathway. Disruption of leptin signaling may represent a novel mechanism in LVH and related cardiovascular disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“For example, while some groups have reported cardiac hypertrophy in hearts of young ob/ob mice (30, 34, 227), others have only observed this phenotype in older animals (23, 24).”
From Cardiac remodeling in obesity (2008) · cites this paper as [23]
In the citing paper
“Similarly, cardiac hypertrophy has been reported in old but not in young db/db mice (23, 24).”
From Cardiac remodeling in obesity (2008) · cites this paper as [23]
In the citing paper
“One report concluded that leptin mediates antihypertrophic effects since infusion of leptin to ob/ob mice, which exhibit LVH, decreased LV wall thickness (23).”
From Cardiac remodeling in obesity (2008) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428
A leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158
Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS
Sadoshima, J., & Izumo, S. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.551 · Cited by 861
Genetics of body-weight regulation
Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 783
Cited by
Sorted by citations
Items 201–300 of 341
Impaired cardiac function in leptin-deficient mice
Ren, J. T., & Ma, H. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0084-0 · Cited by 20
Bigford, G. E., Bracchi-Ricard, V. C., Nash, M. S., & Bethea, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041073 · Cited by 20
Sawaguchi, T., Nakajima, T., Haruyama, A., Hasegawa, T., Shibasaki, I., Nakajima, T., Kaneda, H., Arikawa, T., Obi, S., Sakuma, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225008 · Cited by 20
Proteomic Biomarkers in the Cardiorenal Syndrome: Toward Deciphering Molecular Pathophysiology
He, T., Zhang, Z., Staessen, J. A., Mischak, H., Latosińska, A., & Beige, J. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpaa201 · Cited by 19
Steatotic liver transplantation in the mouse: a model of primary nonfunction
Birsner, J., Wan, C., Cheng, G., Evans, Z. P., Polito, C. C., Fiorini, R. N., Gilbert, G. E., Haines, J. K., Schmidt, M. G., & Chavin, K. D. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2003.11.022 · Cited by 19
Wang, B., & Du, . (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2227258 · Cited by 20
Roles of p38-MAPK in Insulin Resistant Heart: Evidence from Bench to Future Bedside Application
Kumphune, S., Chattipakorn, S. C., & Chattipakorn, N. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319320009 · Cited by 18
Obesity and Preclinical Changes of Cardiac Geometry and Function
Sung, J. K., & Kim, J. (2010) · Korean Circulation Journal · doi:10.4070/kcj.2010.40.2.55 · Cited by 18
Michalski, B. W., Trzciński, P., Kupczyńska, K., Miśkowiec, D. Ł., Pęczek, Ł., Nawrot, B., Lipiec, P., & Kasprzak, J. D. (2016) · Cardiology Journal · doi:10.5603/cj.a2016.0098 · Cited by 18
Leptin and the vasculature in young adults: The African‐ PREDICT study
Ahiante, B. O., Smith, W. T., Lammertyn, L., & Schutte, A. E. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13039 · Cited by 18
Impact of metabolic syndrome on left ventricular mass in overweight and obese hypertensive subjects
Mulè, G., Nardi, E., Cottone, S., Cusimano, P., Incalcaterra, F., Giandalia, M. E., Palermo, A., Mezzatesta, G., & Cerasola, G. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.11.011 · Cited by 18
Keung, W., Cadete, V. J. J., Palaniyappan, A., Jablonski, A., Fischer, M. A., & Lopaschuk, G. D. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31820014f9 · Cited by 17
Rubio, B., Mora, C., Pintado, C., Mazuecos, L., Fernández, A., López, V., Andrés, A., & Gallardo, N. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154453 · Cited by 16
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction
Jalink, E. A., Schonk, A. W., Boon, R. A., & Juni, R. P. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1300375 · Cited by 16
Sullivan, R., McGirr, R., Hu, S. L., Tan, A., Wu, D., Charron, C. L., Lalonde, T. J., Arany, E. J., Chakrabarti, S., Luyt, L. G., et al. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00433 · Cited by 16
Karmazyn, M., Gan, X. T., & Rajapurohitam, V. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0057 · Cited by 16
Alkhaleq, H. A., Kornowski, R., Waldman, M., Levy, E., Zemel, R. R., Nudelman, V., Shainberg, A., Miskin, R., & Hochhauser, E. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112373 · Cited by 15
Beneficial Cardiac Effects of Caloric Restriction Are Lost with Age in a Murine Model of Obesity
AlGhatrif, M., Watts, V. L., Niu, X., Halushka, M. K., Miller, K. L., Vandegaer, K., Bedja, D., Fox-Talbot, K., Bielawska, A. E., Gabrielson, K. L., et al. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9453-4 · Cited by 15
Self-citationPiñeiro, R., Iglesias, M. J., Eirás, S., Viñuela, J. E., Lago, F., & González‐Juanatey, J. R. (2005) · Endocrine Research · doi:10.1080/07435800500456937 · Cited by 13
Ko, K., Wu, Y., Liu, C., Cheng, M., Yen, R., & Yang, W. (2017) · Oncotarget · doi:10.18632/oncotarget.21202 · Cited by 15
Santos, J. L. F., Salemi, V. M. C., Picard, M. H., Mady, C., & Coelho, O. R. (2010) · Obesity · doi:10.1038/oby.2010.253 · Cited by 15
Cohen, C. D., Blasio, M. J. D., Farrugia, G. E., Dona, M. S. I., Hsu, I., Prakoso, D., Kiriazis, H., Krstevski, C., Nash, D. M., Li, M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107759 · Cited by 14
The impact of obesity and hypoxia on left ventricular function and glycolytic metabolism
Rodriguez, R. H., Bickta, J., Murawski, P., & O'Donnell, C. P. (2014) · Physiological Reports · doi:10.14814/phy2.12001 · Cited by 14
Self-citationCardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice
Che, C., Dudick, K., & Shoemaker, R. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0269-z · Cited by 14
Alkhaleq, H. A., Kornowski, R., Waldman, M., Zemel, R. R., Lev, D., Shainberg, A., Miskin, R., & Hochhauser, E. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112647 · Cited by 15
Obesity, Leptin, and Incident Heart Failure
Deswal, A. M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.030 · Cited by 14
Omoto, A. C. M., do Carmo, J. M., Nelson, B. J., Aitken, N. M., Dai, X., Moak, S. P., Flynn, E., Wang, Z., Mouton, A. J., Li, X., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027081 · Cited by 13
The immunology of heart failure with preserved ejection fraction
Smart, C. D., & Madhur, M. S. (2023) · Clinical Science · doi:10.1042/cs20230226 · Cited by 15
Left ventricle relative wall thickness and plasma leptin levels
Blasio, A. D., Donato, F., Stefano, A. D., Gallina, S., Granieri, M., Napolitano, G., Petrella, V., Riccardi, I., Santarelli, F., Valentini, P., et al. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181e57813 · Cited by 13
Effect of leptin on peroxidation and antioxidant defense in ethanol‐supplemented Mus musculus heart
Vairappan, B., & Nalini, N. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00476.x · Cited by 13
Long-Lived αMUPA Mice Show Attenuation of Cardiac Aging and Leptin-Dependent Cardioprotection
Levy, E. A., Kornowski, R., Gavrieli, R., Fratty, I. S., Greenberg, G., Waldman, M., Birk, E., Shainberg, A., Akirov, A., Miskin, R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144593 · Cited by 13
Leptin as a neuroprotective agent in glaucoma
Gupta, A. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.08.023 · Cited by 13
Karmazyn, M., & Gan, X. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021137 · Cited by 12
Lascio, N. D., Kusmic, C., Stea, F., Lenzarini, F., Barsanti, C., Leloup, A. J. A., & Faita, F. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.219 · Cited by 12
Role of Leptin in the Development of Cardiac Hypertrophy in Experimental Animals and Humans
Tritos, N. A., Manning, W. J., & Danias, P. G. (2004) · Circulation · doi:10.1161/01.cir.0000116424.65485.67 · Cited by 12
den Bergh, A. V., Vangheluwe, P., Vanderper, A., Carmeliet, P., Wuytack, F., Janssens, S. P., Flameng, W. J., Holvoet, P., & Herijgers, P. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp156 · Cited by 12
Pedersen, T. M., Boardman, N. T., Hafstad, A. D., & Aasum, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204843 · Cited by 11
Li, D. K., Smith, L. E., Rookyard, A. W., Lingam, S. J., Koay, Y. C., McEwen, H. P., Twigg, S. M., Don, A. S., O’Sullivan, J., Cordwell, S. J., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.11.009 · Cited by 12
Schumann, P., Lindhorst, D., Kampmann, A., Gellrich, N., Krone-Wolf, S., Meyer‐Lindenberg, A., von See, C., Gander, T., Lanzer, M., Rücker, M., et al. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.06.004 · Cited by 11
Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
Papademetriou, V., Tsioufis, C. P., Gradman, A. H., & Punzi, H. A. (2011) · International Journal of Hypertension · doi:10.4061/2011/438198 · Cited by 11
Dludla, P. V., Essop, M. F., Gabuza, K., Muller, C. J. F., Louw, J., & Johnson, R. (2017) · Heart and Vessels · doi:10.1007/s00380-017-0978-3 · Cited by 10
The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction—Victim of Its Environment?
Rocca, A., van Heeswijk, R. B., Richiardi, J., Meyer, P., & Hullin, R. (2022) · Cells · doi:10.3390/cells11050867 · Cited by 10
Adipokines and the Right Ventricle: The MESA-RV Study
Harhay, M. O., Kizer, J. R., Criqui, M. H., Lima, J. A. C., Tracy, R. P., Bluemke, D. A., & Kawut, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136818 · Cited by 10
Ponte, C. M. M., Fernandes, V. O., Liberato, C. B. R., Montenegro, A. P. D. R., Batista, L. A. D. A., Castelo, M. H. C. G., Karbage, L. B. D. A. S., Vasconcelos, I. T. G. F., d’Alva, C. B., & Montenegro, R. M. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0444-8 · Cited by 10
Diabetes and the endocrine heart
Christoffersen, C., Hunter, I., Jensen, A. L., & Goetze, J. P. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm367 · Cited by 10
Shimada, Y. J. (2018) · Hypertension Research · doi:10.1038/s41440-018-0135-0 · Cited by 10
Kachouei, A. A., Singar, S., Wood, A., Flatt, J. D., Rosenkranz, S. K., Rosenkranz, R. R., & Akhavan, N. S. (2025) · Nutrients · doi:10.3390/nu17142328 · Cited by 11
Lazar-Poloczek, E., Romuk, E. B., Jacheć, W., Stanek, W., Stanek, B., Szołtysik, M., Techmański, T., Hasterok, M., & Wojciechowska, C. (2022) · Biomedicines · doi:10.3390/biomedicines10112959 · Cited by 9
Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner
van der Linde, S., Romano, T., Wadley, G. D., Jeffries, A. J., Wlodek, M. E., & Hryciw, D. H. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000245 · Cited by 9
Dependence of β3-adrenergic signaling on the adipokine leptin in cardiac myocytes
Larson, J. E., Rainer, P. P., Watts, V. L., Yang, R., Miller, K. L., Phan, A. C., & Barouch, L. A. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.137 · Cited by 9
Self-citationCardioprotective properties of leptin in patients with excessive body mass
Paduszyńska, A., Sakowicz, A., Banach, M., Maciejewski, M., Dąbrowa, M., & Bielecka-Dabrowa, A. M. (2020) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-020-02211-9 · Cited by 9
Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes
Ruige, J. B., Mertens, I. L., Considine, R. V., Paelinck, B. P., & Gaal, L. F. V. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.06.042 · Cited by 9
Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus
Magri, C. J., Cassar, A., Fava, S., & Felice, H. (2012) · journal of Diabetes Research and Clinical Metabolism · doi:10.7243/2050-0866-1-2 · Cited by 9
Wang, J., Liu, S., Sun, L., Kong, Z., Chai, J., Wen, J., Tian, X., Chen, N., & Xu, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-59559-6 · Cited by 8
Kawada, T., Miyata, S., Shimada, T., Sanzen, Y., Ito, M., Hemmi, C., Iizuka, S., Suzuki, W., Mihara, K., Aburada, M., et al. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.998 · Cited by 8
Lima, V. M., Lino, C. A., Senger, N., Silva, T. D. O., Fonseca, R. I., Bäder, M., Santos, R. A. S., Donato, J., Barreto‐Chaves, M. L. M., & Diniz, G. P. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110576 · Cited by 8
Animal Models of Myocardial Disease
Breckenridge, R. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415894-8.00007-5 · Cited by 8
Cardiovascular Protective Effects of Salvianic Acid A on db/db Mice with Elevated Homocysteine Level
Gao, L., Siu, P. M., Chan, S., & Lai, C. W. K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9506925 · Cited by 7
Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
Imerbtham, T., Thitiwuthikiat, P., Jongjitwimol, J., Nuamchit, T., Yingchoncharoen, T., & Siriwittayawan, D. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s245048 · Cited by 7
Regulation of Oxidative Stress and Cardioprotection in Diabetes Mellitus
Hayashi, T., Mori, T., Yamashita, C., & Miyamura, M. (2008) · Current Cardiology Reviews · doi:10.2174/157340308786349426 · Cited by 7
Modelling ageing and age-related disease
Bellantuono, I., & Potter, P. K. (2016) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2017.07.005 · Cited by 7
Piestrzeniewicz, K., Maciejewski, M., & Goch, J. H. (2008) · Cited by 7
Cardiometabolic Phenotype in HFpEF: Insights from Murine Models
Ogurtsova, E., Arefieva, T. I., Filatova, A. Y., Radyukhina, N. V., & Ovchinnikov, A. G. (2025) · Biomedicines · doi:10.3390/biomedicines13030744 · Cited by 6
Models of hyperglycaemia in diabetes mellitus and its complications
Loo, R. Y. H., Zhang, X., Ching, C., & Teo, A. K. K. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01220-x · Cited by 6
Broderick, T. L., Jankowski, M., & Gutkowska, J. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s115453 · Cited by 6
Development of hyperglycemia and diabetes in captive Polish bank voles
Bartelik, A., Cieśla, M., Kotlinowski, J., Bartelik, S., Czaplicki, D., Grochot‐Przeczek, A., Kurowski, K., Koteja, P., Dulak, J., & Józkowicz, A. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.12.006 · Cited by 6
Xu, M., Ji, H., Dai, D., Tang, X., & Dai, Y. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.6.0009 · Cited by 5
Heart failure--definition and diagnosis.
Ramakrishnan, S., Ss, K., & Vk, B. (2005) · PubMed · Cited by 6
Therapeutic Repurposing of Antidiabetic Drugs in Diabetes-associated Comorbidities
Pathak, K., Pathak, M. P., Saikia, R., Gogoi, U., Das, R. J., Patowary, P., Kaishap, P. P., Bordoloi, S., Das, J., Sarma, H., et al. (2023) · Current Drug Therapy · doi:10.2174/1574885518666230516150404 · Cited by 6
Arias-Mutis, O. J., Calvo, C. J., Bizy, A., Guzmán, J. E. O., Such‐Miquel, L., Such, L., Alberola, A. M., Zhao, J., Chorro, F. J., & Zarzoso, M. (2025) · The Journal of Physiology · doi:10.1113/jp286516 · Cited by 5
Heart Failure as a Consequence of Diabetic Cardiomyopathy
Buren, P. N. V., & LeWinter, M. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5895-3.10026-9 · Cited by 5
Melaku, L. S., & Nebi, T. D. (2019) · International Journal of Health & Allied Sciences · doi:10.4103/ijhas.ijhas_104_17 · Cited by 6
Resl, M., Hülsmann, M., Pacher, R., & Clodi, M. (2009) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-009-0645-0 · Cited by 5
Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus
Gupta, D. M., Griendling, K. K., & Taylor, W. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_14 · Cited by 5
Obesity and cardiac function – the role of caloric excess and its reversal
Sack, M. N. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.05.004 · Cited by 6
Flaht‐Zabost, A., Czarnowska, E., Jankowska-Steifer, E. A., Niderla‐Bielińska, J., Żera, T., Moskalik, A., Bartkowiak, M., Bartkowiak, K., Tomczyk, M., Majchrzak, B., et al. (2024) · Applied Sciences · doi:10.3390/app14198675 · Cited by 4
Jones, A. A., Framnes‐DeBoer, S. N., Shipp, A., & Arble, D. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.963762 · Cited by 4
Weight Loss Drugs and Cardiovascular Risks
Poirier, P. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0148-y · Cited by 4
Khokhlova, A., Myachina, T. A., Butova, X., Kochurova, A. M., Polyakova, E. A., Galagudza, M. M., Solovyova, O. E., Kopylova, G. V., & Shchepkin, D. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158356 · Cited by 4
Zheng, H., Xie, N., Xu, H., Huang, J., Xie, X., & Luo, M. (2013) · Folia Biologica · doi:10.14712/fb2013059060246 · Cited by 4
Rubio, B., Pintado, C., Mazuecos, L., Benito, M., Andrés, A., & Gallardo, N. (2024) · Biomolecules · doi:10.3390/biom14081028 · Cited by 3
Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure
Omoto, A. C. M., do Carmo, J. M., Mouton, A. J., Wang, Z., Li, X., Spitz, R. W., Hall, J. E., & da Silva, A. A. (2024) · Current Hypertension Reports · doi:10.1007/s11906-024-01318-z · Cited by 4
Klinaku, F. T., Comi, L., Giglione, C., & Magni, P. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02516-x · Cited by 4
The Role of Adipose Tissue in Cardiovascular Pathophysiology
Maya-Ramos, L., Gillette, T. G., Hill, J. A., & Scherer, P. E. (2023) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2023.3.e9 · Cited by 3
da Silva, F. A., Freire, L. S., Lima, T. D. R., Santos, S. F., de França, S. A., Gai, B. M., Colodel, É. M., Ávila, E. T. P., Damazo, A. S., Pereira, M. P., et al. (2022) · Nutrition · doi:10.1016/j.nut.2022.111689 · Cited by 3
Antidiabetic Effect of Piper Sarmentosum: A Systematic Review
Azhar, M. N., Ibrahim, F. S., & Muniandy, N. D. (2022) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.18.s15.46 · Cited by 3
Coimbra, S., Catarino, C., Faria, M., Nunes, J. P. L., Rocha, S., Valente, M. J., Rocha‐Pereira, P., Bronze-da-Rocha, E., Bettencourt, N., Beco, A., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11041026 · Cited by 3
The role of adipokines in the regulation of cardiovascular function
Karpushev, A. V., & Михайлова, В. Б. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2019-25-5-448-459 · Cited by 3
The cellular specificity of leptin-mediated actions in the infarcted heart
Dobaczewski, M. P., & Frangogiannis, N. G. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq354 · Cited by 3
Sexual dimorphism in animal models of heart failure with preserved ejection fraction
Bauer, M., Gadkari, M., Yus, M. M., Santhanam, L., & Steppan, J. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00595.2024 · Cited by 2
Liebson, P. R. (2008) · CRC Press eBooks · doi:10.3109/9780203091463-2 · Cited by 2
Guzzardi, M. A., & Iozzo, P. (2013) · Springer eBooks · doi:10.1007/978-3-319-01050-2_2 · Cited by 2
Постоева, А. В., & Dvoryashinva, I. V. (2015) · Obesity and metabolism · doi:10.14341/omet2015210-13 · Cited by 2
Tritos, N. A., Manning, W. J., & Danias, P. G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031987 · Cited by 2
Pascual, F. L., Grevengoed, T. J., Zhao, L., Willis, M. S., & Coleman, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.24.918961 · Cited by 2
Comparative effects of fatty acid and glucose in cardiac remodeling
Duttaroy, A. K., & Mallick, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99570-2.00001-1 · Cited by 1
Pol, T., Lindbäck, J., Oldgren, J., Alexander, J. H., Siegbahn, A., Wallentin, L. C., & Hijazi, Z. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.045970 · Cited by 1
Le tissue adipeux: Son rôle dans les maladies métaboliques
Pégorier, J. P. (2007) · Springer eBooks · doi:10.1007/978-2-287-33475-7_25 · Cited by 1
Cardiovascular complications of obesity and weight loss: pathogenesis and clinical recognition
Poirier, P. (2006) · Hot Topics in Cardiology · doi:10.4147/htc-060200 · Cited by 1
Oxidative stress: a key contributor to diabetic
Singal, P. K. (2010) · Cited by 1
Metadata
- Authors
- Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M.
- Affiliations
- Johns Hopkins University (US)
- From the Department of Medicine, Divisions of Cardiology (L.A.B., R.W.H., J.M.H.) and Pulmonary Medicine (C.P.O.) and the Department of Anesthesia and Critical Care Medicine (D.E.B.), Johns Hopkins Medical Institutions, Baltimore, Md.
- Venue
- Circulation
- Published
- 2003-08-12
- Volume
- 108
- Issue
- 6
- Pages
- 754-759
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2119801354
- Cited by
- 341
- References
- 36
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 17 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 20 · 2016: 8 · 2015: 15 · 2014: 15 · 2013: 26 · 2012: 15
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (K08HL003238, R01HL065455)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin signaling, cardiac hypertrophy, left ventricular hypertrophy, obesity, leptin receptor, ob/ob mice, db/db mice, myocyte hypertrophy, cardiac remodeling, caloric restriction, weight loss, hemodynamic load
- MeSH terms
- Animals, Body Weight, Disease Models, Animal, Cardiomegaly, Heart Ventricles, Hemodynamics, Homozygote, Mice, Inbred C57BL, Mice, Mutant Strains, Myocardium, Obesity, Organ Size, Receptors, Cell Surface, Signal Transduction, Disease Progression, Ventricular Remodeling, Leptin, Myocytes, Cardiac, Mice, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
